Research

Drug Interaction Database

The Drug Interaction Database (referred to as DIDB), part of UW Drug Interaction Solutions, is designed to support research and regulatory scientists in their decision-making when evaluating PK-based drug interactions and drug safety.

The database has the largest manually curated collection of qualitative and quantitative human in vitro and in vivo information related to various extrinsic and intrinsic factors. These factors include interacting co-medications, excipients, food products, herbals, tobacco, organ impairment, and genetics, that can affect drug exposure in humans.
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Pharmacogenomics Research Network (PGRN)

The Pharmacogenomics Research Network (PGRN) is a nationwide collaboration of scientists studying the effect of genes on people’s responses to a wide variety of medicines.

The Northwest-Alaska PGRN focuses on genetic variation among American Indian and Alaska Natives (AI/AN) and rural Pacific Northwest populations. We have created a Center on Pharmacogenetics in Rural and Underserved Populations.
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Pharmacokinetics and Modeling Lab

The PK Lab supports clinical studies through the analysis of drugs in an array of biological matrices (e.g. plasma, urine, lymphocytes), along with analysis and modeling of pharmacokinetic-pharmacodynamic (PK-PD) data. The PK Lab also has the capability to conduct various studies for the in vitro characterization of drug metabolism and transport.
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Targeted Long-Acting Combination Antiretroviral Therapy Program (TLC-ART)

We are scientists and physicians working toward developing a long acting and effective treatment to improve patient compliance and therapeutic outcomes. We hope to maximally suppress HIV and potentially contribute to a cure for AIDS.
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Program on Pharmacokinetics of Drugs of Abuse during Pregnancy (UWPKDAP)

The primary purpose of the program is to elucidate the fundamental mechanisms of maternal-fetal drug disposition in pregnant women with special emphasis on drugs of abuse, treatment of drug abuse.
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University of Washington Research Affiliate Program on Transporters (UWRAPT)

The UWRAPT (University of Washington Research Affiliate program on Transporters) program is a research collaboration between academia and pharmaceutical industry to better understand inter-individual variability in pharmacokinetics and pharmacodynamics of drugs by quantifying the absolute expression of transporters in various tissues and cells.
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The Washington Entrepreneurial Research Evaluation and Commercialization Hub (WE-REACH)

The Washington Entrepreneurial Research Evaluation and Commercialization Hub (WE-REACH) is a public/private partnership designed to facilitate and accelerate the transformation of regional health research innovations into market ready products and services that impact health outcomes.
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