Kenneth Thummel

Milo Gibaldi Endowed Chair, Department of Pharmaceutics; Professor, Department of Pharmaceutics; Adjunct Professor, Department of Environmental and Occupational Health Sciences

Department of Pharmaceutics, Pharmaceutics Faculty, Pharmacogenomics Research Network

Expertise: Cytochrome P450, Drug Interactions, Drug Metabolism, Distribution and Transport, Pharmacogenomics and Personalized Medicine, Pharmacokinetics/Pharmacodynamics

Telephone: (206) 543-0819

Fax: (206) 543-3204

Email: thummel@uw.edu

Office Location: Health Science Building, Room H-272N, Box 357610

Website: PubMed

Education

  • PhD in Pharmaceutical Science, UW

Research Interests

  • Pharmacogenetics and pharmacokinetics
  • Elucidation of genetic, hormonal and environmental factors that contribute to interindividual differences in xenobiotic biotransformation
  • Adverse drug reactions; drug-drug interactions
  • Research ethics and policies for underserved populations

Biography

Kenneth Thummel received his PhD in Pharmaceutical Science from the University of Washington in 1987 and completed a post-doctoral fellowship in Pharmacology at the University of Connecticut Health Science Center.

In 1989, he was appointed to the University of Washington School of Pharmacy faculty, promoted to the rank of Professor in 2001, and was Associate Dean for Research & New Initiatives for the School of Pharmacy from 2003-06. He was appointed Chairman of the Department of Pharmaceutics in 2006 and currently holds the Milo Gibaldi Endowed Chair in Pharmaceutics.

Dr. Thummel is also an Adjunct Professor in the UW Department of Environmental and Occupational Health Sciences. His research interests include the elucidation of genetic, hormonal and environmental factors that contribute to interindividual differences in xenobiotic biotransformation, in particular, intestinal cytochrome P450 3A-mediated first-pass drug metabolism.

Dr. Thummel is a Fellow of the American Association for the Advancement of Science and the American Association of Pharmaceutical Scientists. He is currently an Associate Editor for Molecular Pharmacology and President-elect of the American Society for Pharmacology and Experimental Therapeutics. He is also involved in the development of a “kidney on a chip” microphysiological system that can be used in preclinical drug toxicity screening.

Selected Publications

Fohner A, Wang Z, Yracheta J, O’Brien D, Hopkins SE, Boyer BB, Black J, Wiener HW, Tsai J, Janssen P, Austin M, Thornton T, Thummel KE. Genetics, diet, and season are associated with serum 25-hydroxylated cholecalciferol concentration in a Yup’ik study population from southwestern Alaska. Journal of Nutrition. E-Pub ahead of print; Dec 9, 2015.

Fohner AE, Robinson RF, Yracheta J, Dillard D, Schilling B, Kahn B, Hopkins S, Boyer B, Black J, Gordon A, Nickerson D, Tsai J, Farin F, Thornton TA, Rettie AE, and Thummel KE. Variation in Genes Controlling Warfarin Disposition and Response in the American Indian and Alaska Native Population: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX. Pharmacogenetics & Genomics. 25(7):343-53, 2015.

Wang Z, Wong T, Hashizume T, Dickmann LZ, Scian M, Koszewski NJ, Horst RL, Chaudhry A, Schuetz EG, Kharasch ED and Thummel KE. Human UGT1A3 and UGT1A4 conjugate 25-hydroxyvitamin D3: Metabolite structure, kinetics, inducibility and interindividual variability. Endocrinology, 155(6):2052-63, 2014.

Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD and Thummel KE. Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intra-renal tacrolimus disposition. Clin Pharmacol Ther. 92(6):737-45, 2012.

Wang Z, Senn T, Hashizume T, Scian M, Dickmann LJ, Nelson SD, Baillie TA, Hebert MF, Connie L. Davis CL, Yvonne S. Lin YS, Thummel KE: An inducible Cytochrome P450 3A4-dependent vitamin D catabolic pathway. Mol Pharmacol. 81(4):498-509, 2012.