School of Pharmacy

Nina Isoherranen

Professor and Milo Gibaldi Endowed Chair, Pharmaceutics

Department of Pharmaceutics, Pharmaceutics Faculty, School Faculty, UWPKDAP

Telephone: (206) 543-2517

Email: ni2@uw.edu

Office Location: Health Science Building Room H-272M Box 357610 Seattle, WA 98195-7610

Website: Isoherranen Lab

Expertise: Addiction Medicine, Drug Discovery, Drug Metabolism, Mechanisms-of-Drug-Interactions, Obesity and Bariatric Surgery, Pharmacokinetics-Pharmacodynamics, Pregnancy and Fetal Pharmacology, Transgender-and-Gender-Diverse-Research, Vitamins

Education

  • PhD in Pharmaceutical Sciences, Hebrew University of Jerusalem
  • Master of Science in Analytical Chemistry
  • Bachelor of Science in Chemistry, University of Helsinki

Research Interests

  • Metabolism, disposition and biological effects of Vitamin A and Retinoic acid
  • Drug disposition and drug safety during pregnancy
  • Pharmacokinetic modeling and molecular mechanisms of drug-drug interactions

Courses Taught

  • PCEUT532
  • PCEUT506
  • PCEUT502

Biography

Dr. Isoherranen received her bachelor’s degree in chemistry and her master’s degree in Analytical Chemistry in 1998 from the University of Helsinki, Finland. She obtained a PhD from the Hebrew University of Jerusalem in 2003 and continued her training as a post-doctoral fellow with Ken Thummel at the University of Washington. She joined the Department of Pharmaceutics as an Acting Assistant Professor on November 2004.

Dr Isoherranen’s main research interests relate to vitamin A disposition, pharmacokinetic modeling and drug-drug interactions. Her research program includes studies of the role of CYP26 and ALDH1A enzymes in Vitamin A homeostasis, alterations in vitamin A metabolome in obesity and related comorbidities and characterization of how drug and vitamin metabolism change during pregnancy. She has also active research ongoing in the area of pharmacokinetic modeling and PBPK model development relating to predictions of complex drug-drug and disease-drug interactions, and in prediction of clearance changes in different physiological states.

Selected Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=Isoherranen+N