School of Pharmacy

Edward Kelly

Associate Professor, Pharmaceutics Adjunct Associate Professor, Environmental & Occupational Health Sciences Co-Director, Pharmaceutical Bioengineering Program

Department of Pharmaceutics, Pharmaceutics Faculty, School Faculty, UWPKDAP

Telephone: (206) 685-4641

Email: edkelly@uw.edu

Office Location: 1959 NE Pacific St, HSB Rm H272D

Website: Lab website

Expertise: Analytical Techniques, Biotechnology, Drug Metabolism, Drug Transporters, Microphysiological organ systems, Toxicology, Translational Research

Education

  • BS, Biochemistry, UC-Riverside
  • MS, Biochemistry, UC-Riverside
  • PhD, Biochemistry, University of Washington

Research Interests

  • Drug and Xenobiotic-induced Toxicity
  • 3D Microphysiological Systems aka Tissue Chips

Courses Taught

  • PCEUT 586 (Biotechnology and Biopharmaceuticals)
  • PCEUT 520 (Departmental Seminar Series)
  • PHARBE 510 (Applied Pharmacokinetics)

Biography

In the broadest sense, the Kelly lab research interests are within the realm of preclinical biology. In particular, we are interested in applying novel technology platforms to address the 3 Rs of toxicology in animal testing, reduce, refine and replace.

Active areas of research in the Kelly lab focus on ex vivo modeling of human organ physiology and toxicological responses to drug/xenobiotic challenge. These project makes use of “organs on chips” or microphysiological systems (MPS) populated with primary and stem-cell derived cell types to recapitulate two key ADME organs, the liver and kidney as alternatives to preclinical animal toxicology studies.

Recent work is extending MPS technologies to model select human diseases as well as how organs respond to the extreme environment of microgravity on the International Space Station.

Selected Publications

  1. Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J & Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney International 90(3): 627-637. 2016. PMID: 27521113.
  2. Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly EJ, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP & Taylor DL. Functional coupling of human microphysiology systems: Intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 7:42296, 2017. PMID: 28176881.
  3. Chang S-Y, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen DD, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J & Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. Journal of Clinical Investigation-Insight Nov 16; 2(22), 2017. PMID: 29202460.
  4. Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J & Kelly EJ. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. Journal of Clinical Investigation-Insight Dec 20; 3(24), 2018. PMID: 30568031.

For a full list, please see: https://www.ncbi.nlm.nih.gov/myncbi/edward.kelly.1/bibliography/public/