The School of Pharmacy Mass Spectrometry Center is home to 12 mass spectrometers and LCs that are available for use by students, staff, faculty and outside users.
High Resolution / High Mass Accuracy Instruments:
AB Sciex 5600 TOF
AB Sciex 5600 TOF
The TripleTOF 5600+ System is an innovation in LC-MS/MS performance that uniquely integrates comprehensive, qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform. It combines high-sensitivity detection, high resolution with the fast acquisition speeds, and stable mass accuracy over days of acquisition. Predominate use is for intact mass analysis of proteins.
Link to AB Sciex 5600 TOF
Bruker TimsTOF Pro
Bruker TimsTOF Pro
The TimsTOF FleX, powered by the latest parallel accumulation serial fragmentation (PASEF®) technology, paves the way for 4D-Multiomics applications. The TimsTOF FleX is a fully functional high speed, high sensitivity ESI instrument for all your Omics analyses with integrated MALDI source for fast MALDI Imaging. Proven robustness, high sensitivity and fast MS/MS acquisition. TimsTOF FleX is the platform of choice for tissue imaging, Proteomic, Metabolomics and 4D-Lipidomics. Predominately used for MALDI tissue imaging.
Link to TimsTOF
Thermo Ascend Tribrid
Thermo Ascend™ Tribrid™
Thermo Scientific™ Orbitrap™ Ascend Tribrid™ mass spectrometer delivers ultimate throughput and versatility for multiplexed quantitative proteomics and native protein characterization. Characterize the largest biopharmaceuticals with a mass range up to m/z 16,000. Predominate use is for peptide mapping and structural elucidation.
Link to Ascend
Thermo Eclipse Tribrid
Thermo Eclipse™ Tribrid™
The Thermo Scientific Orbitrap Eclipse mass spectrometer incorporates the latest inventions in ion transmission and control, extended m/z range, and real-time decision making to expand the breadth of your work and push your science beyond today’s discovery. This system is ideally suited for proteomics, structural biology, small-molecule, and biopharmaceutical characterization experiments. Predominate use is for peptide mapping and structural elucidation.
Link to Eclipse
Waters Synapt - G2-Si
Waters Synapt G2-Si:
SYNAPT G2-Si enables extensive characterization of complex mixtures and molecules with uncompromising qualitative and quantitative performance, streamlined workflows and unparalleled platform versatility. Ion mobility allows for additional separation and identification in complex mixtures. Perfect for MetID experiments, HDX experiments, intact mass and accurate mass for small molecules. Predominate use is for HDX experiments.
Link to Synapt G2-Si
Waters Synapt XS
Waters Synapt XS
SYNAPT XS enables extensive characterization of complex mixtures and molecules with uncompromising qualitative and quantitative performance, streamlined workflows and unparalleled platform versatility. Ion mobility allows for additional separation and identification in complex mixtures. Perfect for MetID experiments, HDX experiments, intact mass and accurate mass for small molecules. Predominate use is for lipidomic experiments.
Link to Synapt XS
Triple Quad Instruments:
Waters Xevo TQ-S
Waters Xevo TQ-S
Waters Xevo TQ-S mass spectrometer designed for the most demanding quantitative UPLC-MS/MS applications. The tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness. Predominate use is for targeted quantitative analysis, specifically pharmaceutical pharmacokinetic studies.
Link to Xevo TQ-S
Waters Xevo XS
Waters Xevo XS
Waters Xevo XS mass spectrometer, the most sensitive tandem quadrupole available in the Center. It is designed for the most demanding quantitative UPLC-MS/MS applications. The ultimate in tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness. Predominate use is for targeted quantitative analysis, targeted peptide quantitation, pharmacokinetic studies, and residue studies for pesticides and harmful substances.
Link to Xevo XS
MALDI, GC and UV/Vis Fraction Collector:
Bruker Biotyper
Bruker Biotyper
The MALDI Biotyper (MBT) is a microbial identification system based on Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS), allowing unbiased identification of microorganisms within a few minutes down to the species level. The MALDI Biotyper® is an easy, rapid, robust, high-throughput, cost-effective and efficient identification technology. Predominately used for Bacterial ID, polymer analysis and peptide/protein analysis.
Link to Biotyper
Bruker TimsTOF FleX with mirogrid
Bruker TimsTOF FleX with mirogrid
The TimsTOF FleX, powered by the latest parallel accumulation serial fragmentation (PASEF®) technology, paves the way for 4D-Multiomics applications. The TimsTOF FleX is a fully functional high speed, high sensitivity ESI instrument for all your Omics analyses with integrated MALDI source for fast MALDI Imaging. Proven robustness, high sensitivity and fast MS/MS acquisition. TimsTOF FleX is the platform of choice for tissue imaging, Proteomic, Metabolomics and 4D-Lipidomics. Predominately used for MALDI tissue imaging.
Link to TimsTOF
UV/Vis DAD With Fraction Collector
1290 Agilent Infinity UPLC Stack
Agilent 1260 Fraction Collector
Agilent DAD UV/Vis Detector
