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Department of Medicinal Chemistry

Instruments

The School of Pharmacy Mass Spectrometry Center is home to 11 mass spectrometers and LCs that are available for use by students, staff, faculty and outside users.

High Resolution / High Mass Accuracy Instruments:

AB Sciex 5600 QTOF
LC-MS/MS (QTOF)
Tandem Quadrupole MS
General application: The TripleTOF 5600+ System is an innovation in LC-MS/MS performance that uniquely integrates comprehensive, qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform. It combines high-sensitivity detection, high resolution with the fast acquisition speeds, and stable mass accuracy over days of acquisition.
Agilent 6520 Accurate Mass QTOF
LC-Tof-MS (QTOF) – Quadrupole MS
General application: Fully automated quantitative analysis of drugs and metabolites.
Agilent_6520_Accurate_Mass_QTOF
Waters Synapt - G1 QTOF
LC-MS/MS (QTOF)
Tandem Quadrupole MS
General application: High sensitivity fully automated quantification and screening. Drug metabolism and interaction studies. Data dependent analysis of complex biological extracts.
Waters_Synapt_G1_QTOF
Waters Synapt - G2 HDX QTOF
LC-MS/MS (QTOF)
Tandem Quadrupole MS
General application: High sensitivity fully automated quantification and screening. Drug metabolism and interaction studies. Data dependent analysis of complex biological exdivacts.
Waters_Synapt_G2_HDX_QTOF
Thermo LTQ-OT
LTQ [FT(OT)]
Tandem Hybrid MS/MS
General application: Capillary LC/MS/MS of proteolytic digests of simple and complex mixtures.
Thermo_LTQ-OT

Triple Quad Instruments:

Agilent 6460 QQQ
LC-MS (QQQ) – Quadrupole MS
General application: Drug metabolism and interaction studies. Data dependent analysis of complex biological extracts.
Agilent_6460_QQQ
Waters Xevo TQ-S-1
LC-MS/MS (QQQ)
Tandem Quadrupole MS
General application: High sensitivity fully automated quantification and screening. Drug metabolism and interaction studies. Data dependent analysis of complex biological extracts.
Waters_Xevo_TQ-S
Waters Xevo TQ-S-2
LC-MS/MS (QQQ)
Tandem Quadrupole MS
General application: High sensitivity fully automated quantification and screening. Drug metabolism and interaction studies. Data dependent analysis of complex biological extracts.
Waters_Xevo_TQ-S
AB/Sciex API4000 Qtrap
LC-MS/MS (Qtrap)
Tandem Quadrupole MS
General application: Drug metabolism and interaction studies. Data dependent analysis of complex biological extracts
ABI4000Qtrap
AB/Sciex 6500
LC-MS/MS (QQQ)
Tandem Quadrupole MS
General application: High sensitivity fully automated quantification and screening. Quantitative proteomics, drug metabolism and interaction studies.
AB_6500

MALDI, GC and UV/Vis Fraction Collector:

Bruker Autoflex II
LC-MS (Q) – Quadrupole MS
General application: Drug metabolism and interaction studies. Data dependent analysis of complex biological extracts.
Bruker_Autoflex_II
SHIMADZU QP2010 GC-MS
GC-MS(Q) – Quadrupole MS
General application: Automated quantitative and qualitative analysis. Drugs, metabolites, and endogenous compound studies. Characterization and Identification of synthetic and natural products.
Shimadzu_QP_2010
UV/Vis DAD With Fraction Collector
1290 Agilent Infinity UPLC Stack
Agilent 1260 Fraction Collector
Agilent DAD UV/Vis Detector