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Department of Medicinal Chemistry

Thermo LTQ-OT

Thermo Linear Trap Quadrupole Orbitrap Xclaibur 2.0 DS

Manufacturer: Thermo Electron Corp., San Jose, CA, USA
Mass range: ~ 2000 Dalton
Resolution: Unit mass (LTQ MS)
~ 60,000 [FT(OT) MS]
Ionization (±eV): ± Electrospray Ionization (ESI)
Inlet Systems:
  • Waters ACQUITY nano Ultra Performance LC™ (UPLC™) with Autosampler, Direct Infusion Syringe Pump (Waters Corp., Milford, MA)
  • Features: Data Dependent Acquisition
Sampling System:
  • Waters ACQUITY UPLC™ System
Data System:
  • Microsoft Windows 7
  • Excalibur 2.0 SR1™
Acquisition Date: 2006
Funding: The National Institutes of Health (NIH): NCRR 1 S10 RR17262-01 award entitled: “Fourier transforms-ion cyclotron-resonance mass spectrometer”
Predominant Uses:
  • Automated “shotgun” proteomic analysis – Combining nano-LC, data dependent MS/MS with high sensitivity (sub fmol on-column) and accurate mass measurement (2 ppm) for protein identifications in simple and complex protein mixtures
  • LC/MS/MS, label-free quantification, and accurate mass measurements.