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Department of Medicinal Chemistry

AB Sciex 5600 QTOF

Manufacturer: AB Sciex
Summary:
  • The TripleTOF 5600+ System is an innovation in LC-MS/MS performance that uniquely integrates comprehensive, qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform. It combines high-sensitivity detection, high resolution with the fast acquisition speeds, and stable mass accuracy over days of acquisition.

Resolution:
  • >30,000 FWHM

Ionization (±eV):
  • Duo Spray with EasyMass™ Accuracy – without constant recalibration, over 50 hours of continuous LC-MS operation provides stable mass accuracy
  • Electrospray & Atmospheric Pressure Chemical Ionization
Inlet Systems:
  • Inlets: I-Class Acquity UPLC, Direct Infusion Syringe Pump
  • Infusion: Direct infusion
Data System (DS):
  • Windows 7
  • MS/MS ALL with SWATH® Acquisition – enabling comprehensive MS/MS quantitation in proteomics
  • Tools for 21 CFR 11 Compliance – in Analyst® TF 1.6 and MultiQuant™ Software, bringing the power of accurate mass to regulated bioanalysis
Acquisition Date: 2018
Funding:
  • Prof. Bhagwat Prassad
  • Mass Spectrometry Center Equipment Budget
Predominant Uses:
  • Data dependent LC/MS/MS analysis
  • Protein and Peptide Quantification
  • Metabolomic profiling and bio-marker discovery/validation