The following list represents previously developed and validated drug assays established in the UW Pharmacokinetics Laboratory. Most have been validated according to FDA guidelines for bioanalytical methods. For research projects requiring analysis of these drugs, the timeline may be expedited since method development is already complete. Metabolites and other products are listed below the main compound, when applicable.
Alpha-2 Agonists
- Clonidine (plasma)
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- Hydroxyclonidine
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- Dexmedetomidine (plasma)
Analgesics
- Aspirin (plasma)
-
- Acetylsalicylic acid
- Salicylic acid
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- Ibuprofen (plasma)
-
- Chiral separation
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Anesthetics (General)
- Propofol (plasma)
Anesthetics (Local)
- Bupivacaine (plasma)
- Lidocaine (plasma)
Antibiotics
- Amoxicillin (plasma)
Anticholinergics
- Atropine (plasma)
Antidepressants
- Bupropion (plasma)
-
- Hydroxybupropion
-
- Desipramine (in vitro)
- Sertraline (plasma)
Antidiabetics
- Glyburide (plasma)
-
- 4-trans-hydroxycyclohexyl glyburide
- 3-cis-hydroxycyclohexyl glyburide
- 4-cis-hydroxycyclohexyl glyburide
- 3-trans-hydroxycyclohexyl glyburide
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- Metformin (plasma, breast milk, urine)
- Tolbutamide (urine)
-
- Hydroxytolbutamide
- Carboxytolbutamide
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Antineoplastics
- Busulfan (plasma)
-
- Tetrahydrothiophene
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- Clofarabine (plasma)
- Cyclophosphamide (plasma, in vitro)
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- Hydroxycyclophosphamide (HCY)
- (S)-2-ethyl-1,5-dimethyl-3,3-diphenyl pyrrolidine (S-EDDP)
- Dechloroethylcyclophosphamide (DCCY)
- Aldophosphamide (AldoCY)
- Carboxyethylphosphoramide mustard (CEPM)
- 4-glutathionylcyclophosphamide (GSCY)
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- Docetaxel (plasma)
- Doxorubicine (plasma, tissue)
- Fludarabine (plasma)
- Melphalan (plasma)
- Temozolomide (plasma)
Antivirals
- Nelfinavir (plasma)
- Efavirenz’
- Lamivudine
- Abacavir
- Bictegravir
Beta Blockers
- Carvedilol (plasma)
- Metoprolol (plasma, breast milk, urine)
-
- Chiral separation
- α-hydroxymetoprolol
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Calcium Channel Blockers
- Felodipine (plasma)
Cardiac Glycosides
- Digoxin (plasma)
CNS Stimulants
- Caffeine
-
- Plasma: 1,7-dimethylxanthine
- Urine: methylxanthines and methyluric acids
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Corticosteroids
- Cortisol/Cortisone
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- Cortisol (plasma, urine)
- Cortisone (plasma, urine)
- 6β-hydroxycortisol (urine)
- 6β-hydroxycortisone (urine)
-
- Prednisone (urine)
- Prednisolone (urine)
Hormones
- Epinephrine (plasma)
- Estradiol (in vitro)
-
- Estradiol-2-glucuronide
- Estradiol-3-glucuronide
-
Immunosuppressants
- Mycophenolic acid (plasma)
-
- Mycophenolic acid glucuronide
- Bound vs. free separation
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Muscle Relaxants
- Chlorzoxazone (plasma)
-
- Hydroxychlorzoxazone
-
NMDA Receptor Antagonists
- Memantine (plasma)
Opioids
- Fentanyl (plasma)
- Methadone (plasma)
- Morphine (plasma)
-
- Morphine-3-glucuronide
- Morphine-6-glucuronide
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- Oxycodone (plasma)
-
- Oxymorphone
- Noroxycodone
- Noroxymorphone
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- Remifentanyl (plasma)
- Hydroxymorphone (plasma)
Proton Pump Inhibitors
- Omeprazole (plasma)
-
- Hydroxyomeprazole
-
Selective Estrogen Receptor Modulators (SERMs)
- Tamoxifen (plasma)
-
- 4-hydroxytamoxifen
- Endoxifen
- n-Desmethyltamoxifen
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Statins
- Pravastatin (plasma)
Supplements
- Coenzyme Q10
-
- Reduced “ubiquinol” and oxidized “ubiquinone” separation
-
- Curcuminoids (plasma)
-
- Curcumin
- Desmethylcurcumin
- Bisdesmethylcurcumin
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- Garlic metabolites (breath)
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- Allyl methylsulfide
- Diallyl sulfide
- Diallyl disulfide
- Diallyl trisulfide
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- Hypericin (plasma)
- N-acetyl-S-allyl cysteine (urine)
- S-allyl cysteine (plasma)
- Nicotinamide riboside (whole blood)
-
- Nicotinamide adenosine dinucleotide
- Nicotinamide mononucleotide
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Other
- Dextromethorphan (in vitro)
- 4β-Hydroxycholesterol (plasma)
- Xanthosine monophosphate (lymphocytes)