Skip to content

Representative Publications

Diestelhorst C, Boos J, McCune JS, Russell J, Kangarloo SB, Hempel G. Physiologically-Based Pharmacokinetic Modelling of Busulfan: A New Approach to Describe and Predict the Pharmacokinetics in Adults. Cancer Chemother Pharmacol 2013 Nov;72(5):991-1000. Epub 2013 Sep 6. PMID: 24061863.

Bemer MJ, Sorror M, Sandmaier BM, O’Donnell PV, McCune JS. A Pilot Pharmacologic Biomarker Study in HLA-Haploidentical Hematopoietic Cell Transplant Recipients. Cancer Chemother Pharmacol 2013 Sep;72(3):607-18. Epub 2013 Aug 2. PMID: 23907443.

McDermott CL, Sandmaier BM, Storer B, Li H, Mager DE, Boeckh MJ, Bemer MJ, Knutson J, McCune JS. Non-relapse mortality and mycophenolic acid exposure in nonmyeloablative hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2013 Aug;19(8):1159-66. doi: 10.1016/j.bbmt.2013.04.026. Epub 2013 May 6. PMID: 23660171.

Jaklic A, Collins CJ, Mhrar A, Sorror ML, Sandmaier BM, Bemer MJ, Locatelli I, McCune JS. High prevalence of potential drug interactions (PDI) affecting mycophenolic acid in nonmyeloablative hematopoietic cell transplant (HCT) patients. Int J Clin Pharmacol Ther. 2013 Sep;51(9):711-7. doi: 10.5414/CP201884. PMID: 23782584.

Rezvani A, McCune JS, Storer BE, Batchelder A, Kida A, Deeg HJ, McDonald GB. Cyclophosphamide followed by intravenous targeted busulfan for allogeneic hematopoietic cell transplantation: pharmacokinetics and clinical outcomes. Biol Blood Marrow Transplant 2013 Jul;19(7):1033-1039. doi: 10.1016/j.bbmt.2013.04.005. Epub 2013 Apr 10. PMID: 23583825

Li H, Mager DE, Sandmaier BM, Maloney DG, Bemer MJ, McCune JS. Population Pharmacokinetics and Dose Optimization of Mycophenolic Acid in HCT Recipients Receiving Oral Mycophenolate Mofetil. J Clin Pharmacol. 2013 Apr;53(4):393-402. doi: 10.1002/jcph.14. Epub 2013 Feb 4. PMID: 23382105.

Abassi N, Vadnais B, Knutson JA, Blough DK, Kelly EJ, O’Donnell PV, Deeg HJ, Pawlikowski MA, Ho RJ, McCune JS. Pharmacogenetics of Intravenous and Oral Busulfan in Hematopoietic Cell Transplant Recipients. J Clin Pharmacol. Published online before print December 6, 2010, doi: 10.1177/0091270010382915

Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF. CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6.

Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GD, Clark SM, Risler L, Wang J, Kelly EJ, Shen DD, Hebert MF. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos. 2010 May;38(5):833-40.

Cherrier MM, Amory JK, Ersek M, Risler L, Shen DD. Comparative cognitive and subjective side effects of immediate-release oxycodone in healthy middle-aged and older adults. J Pain. 2009 Oct;10(10):1038-50.

McCune JS, Batchelder A, Guthrie KA, Witherspoon R, Appelbaum FR, Phillips B, Vicini P, Salinger DH, McDonald GB. Personalized dosing of cyclophosphamide in the total body irradiation-cyclophosphamide conditioning regimen: a phase II trial in patients with hematologic malignancy. Clin Pharmacol Ther. 2009 Jun;85(6):615-22.

Buchanan ML, Easterling TR, Carr DB, Shen DD, Risler LJ, Nelson WL, Mattison DR, Hebert MF. Clonidine pharmacokinetics in pregnancy. Drug Metab Dispos. 2009 Apr;37(4):702-5.

Woodahl EL, Wang J, Heimfeld S, Sandmaier BM, O’Donnell PV, Phillips B, Risler L, Blough DK, McCune JS. A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patients. Cancer Chemother Pharmacol. 2009 Feb;63(3):391-401.

Salinger DH, McCune JS, Ren AG, Shen DD, Slattery JT, Phillips B, McDonald GB, Vicini P. Real-time dose adjustment of cyclophosphamide in a preparative regimen for hematopoietic cell transplant: a Bayesian pharmacokinetic approach. Clin Cancer Res. 2006 Aug 15;12(16):4888-98.

Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther. 2006 May;79(5):461-79.

Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.

McCune JS, Risler LJ, Phillips BR, Thummel KE, Blough D, Shen DD. Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81.

Shen DD, Artru AA, Adkison KK. Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics. Adv Drug Deliv Rev. 2004 Oct 14;56(12):1825-57.

Lalovic B, Phillips B, Risler LL, Howald W, Shen DD. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54.

Bernards CM, Shen DD, Sterling ES, Adkins JE, Risler L, Phillips B, Ummenhofer W. Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 2): effect of epinephrine. Anesthesiology. 2003 Aug;99(2):466-75.

Bernards CM, Shen DD, Sterling ES, Adkins JE, Risler L, Phillips B, Ummenhofer W. Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 1): differences among opioids. Anesthesiology. 2003 Aug;99(2):455-65.

Erjavec MK, Coda BA, Nguyen Q, Donaldson G, Risler L, Shen DD. Morphine-fluoxetine interaction in healthy volunteers – Analgesia and side effects. J Clin Pharmacol. 40, 1286-95, 2000.