Research Projects

The CHOICE Faculty are involved in a wide range of funded and unfunded research projects. They have been at the forefront of creating the next generation of thinkers and leaders in the field of economic evaluations, drug safety, and health care economics. They are known internationally for their work on developing and applying methods to critically assess information needs to improve population health and prioritize research investments given limited budgets. They are collaborating with some of the leading initiatives (e.g. Institute for Clinical and Economic Review (ICER)) in the nation in assessing the value of new interventions.  In addition, the CHOICE Institute has a rich history of working with decision makers, such as patients, physicians, industry and payers, providing expertise, and facilitating collaborations at the regional, national, and global level.

The future of the CHOICE faculty is bright.  The faculty are poised to address many national and global challenges – from continued opportunities to inform national policy, to studying changes to the Affordable Care Act and triple aim health care, guiding WA state to achieve effective universal health insurance coverage,  to determining value and guiding best practices with the increase in personalized medicines, to understanding how human behavior affects medication adherence and clinical results, to the rise of technology in healthcare, to better ensuring favorable benefit-risk of medicines and other health technologies, to growing the international platform and linking with the important work done through the Global Medicines Program.

A list of active research projects are listed here. Specific projects that have generated research resources are also highlighted under specific tabs on the right.

Joseph Babigumira
Framework for return on investment in pharmaceutical quality assurance in middle-income countries. U.S. Pharmacopeial Convention, 2017 – 2019

Aasthaa Bansal
PI: Personalized Risk-Adaptive Surveillance Strategies in Cancer (PRAISE); NIH (R37), 07/01/2018-06/30/2023

Doug Barthold
PI: Alzheimer’s disease related neuropathology among patients with medication treated type 2 diabetes in a community-based autopsy cohort; UW ADRC Pilot, 2019-2020
Co-I: (PI Graham): Acceptability of sustained-release antiretrovirals for treatment in the US and sub-Saharan Africa; NIH (R01), 2019-2024
Co-I: (PI: Zissimopoulos): Effectiveness of therapeutics and health care services in reduction of health disparities in Alzheimer’s disease; NIA (R01), 2017-2020

Anirban Basu
PI: Empowering the Annual Health Econometrics Workshop; AHRQ, 2017-2019
PI: Value of Information Methods for NHLBI Trials; NHLBI (R01), 4/15/2015 – 3/31/2019
PI: Cure Sickle Cell, Model for Economic Analysis of Sickle Cell (CureSC: MEASURE); NHLBI, 07/01/2019 – 06/30/2022
Co-PI (PI: Coleman, Kaiser Permanente): Effectiveness of Gastric Sleeve vs. Gastric Bypass for Cardiovascular Disease; NHLBI R01, 2016-2019
Co-I: (PI: Carlson) ICER Economic Modeling; ICER, 1/2020-12/2021

Denise Boudreau
PI, The risks of opioid misuse, abuse and addiction among patients treated with extended-release/long acting (ER/LA) opioids for the treatment of chronic pain, Campbell Alliance, Ltd. 2015-2020.
Co-Investigator/Task Order Lead, Evaluation of the Risk of Neural Tube Defects Among Live Births Exposed to Maternal Prescription Opioids During Early Pregnancy. FDA, 2016-2019.
Co-Investigator, Primary Care Opioid Use Disorders Treatment Trial (PROUD) Coordinating Center, National Institute on Drug Abuse, 2017-2020.

Josh Carlson
PI: ICER Economic Modeling; ICER, 1/2020-12/2021
PI: (subcontract) BEAT MS clinical trial; Benaroya Research Institute at Virginia Mason and NIAID, 2/2019 – 2/2021
PI: (subcontract) Oncology Value-based Pricing Project; Fred Hutchinson Cancer Research Center and BMS, 1/2019 – 4/2020

Beth Devine
PI: Customizing Value-based Methods to Prioritize Implementation of Pharmacogenomic Clinical Decision Support for Learning Health Systems. (PRECISE-VALUE); AHRQ, 2019-2021
Site PI: Assistant Director: Pacific Northwest Evidence-based Practice Center (EPC) VI; AHRQ, 2019-2024
Lead Co-I (PI: Goddard, Kaiser Permanente Center for Health Research): Cancer Health Assessments Reaching Many (CHARM); NHGRI, 2018-2021
Lead Co-I (PI: Czerniecki, VA Center for Limb Loss and Mobility): Improving Dysvascular Amputee Outcomes by Enhancing Shared Decision Making (AMP-DECIDE); VAHSR&D, 2018-2022
Lead Co-I (PI: Basu): Cure Sickle Cell, Model for Economic Analysis of Sickle Cell (CureSC: MEASURE); NHLBI, 2019-2022
PI: UW-Allergan Post-Doctoral Fellowship (Training Grant); Allergan Pharmaceuticals, 2012 –
Lead Co-I (PI: Veenstra): Payer Demand for RWE in HTA: A DCE, Health Technology Fund, UW Outcomes Corporate Advisory Board, 2018-2020
Key personnel (Site PI: Gray): US Deprescribing Research Network; NIA, 2019-2021
Co-I (PI: Bowen): Randomized trial of genetic testing methods for primary care patients (PICNIC); NHGRI, 2020-2024
Associate Director: UW Health Services Research T32; AHRQ, 2018-2023
Faculty Mentor: UW Biomedical and Health Informatics T32; NLM, 2017-2022
Faculty Mentor: UW Developing Data-Driven Cancer Researchers T32; NCI, 2016-2021

Louis Garrison, Jr. 
Principal Mentor, UW-Pfizer Post-Doctoral Fellowship, 2016-2018.
Co-Inv. (PI-Chung) University of Nairobi HIV Capacity Building Fellowship. USAID, 2014-2018

Ryan Hansen
Co-I: National Association of Chain Drug Stores (NACDS) Foundation: Gaps in Care (Community Pharmacy Increasing Statin Utilization for People with Diabetes)
Team Lead: Institute for Clinical and Economic Review: Comparative Value Modeling Team
Co-I: National Institutes of Health (NIH): Pilot Study of a Community-Pharmacy Model to Expand Access to Medications to Treat and Prevent Hepatitis C, Opioid Use Disorders, Overdose and HIV Among Persons Who Inject Drugs
Co-I: Washington State Department of Health (sub from CDC): Support ACT Prescription Drug Monitoring Program
Co-I: Cystic Fibrosis Foundation: Cost Effectiveness Analysis and Comparative Effectiveness Research of STOP2

Zachary Marcum
Scholar/PI: Paul B. Beeson Emerging Leaders Career Development Award in Aging; NIA, 08/01/19-05/31/22
Co-I: (Co-PIs Phelan and Gray): Reducing CNS-active Medications to Prevent Falls and Injuries in Older Adults; Centers for Disease Control and Prevention, 09/01/18-8/31/22

Scott Ramsey
Ramsey Sub-PI (Main PI Charles Blanke, OSHU)
Ancillary Study to Evaluate Patient and Physician Knowledge, Attitudes, and Preferences Related to Return of Genomic Results in the SWOG 1400 (S1400) Clinical Trial. Project Dates 8/2016-2/2018

Lotte Steuten
Co-PI (PI-Hsu); Statistical Methods for Genetic Epidemiologic Studies; NIH/NCI, 2015-2019
Co-I (PI: Feng/Thornquist/Pepe), The Early Detection Research Network: Data Management and Coordinating Center; NIH/NCI 2000-2021

Andy Stergachis
PI of UW Subcontract (Main PI: Aboagye-Nyame) Medicines, Technologies, and Pharmaceutical Services (MTaPS); USAID
PI of UW Subcontract (Main PI: Buekens).  Landscape Analysis:  Sentinel Site Readiness for Maternal Immunization Active Safety Surveillance in LMIC; Bill & Melinda Gates Foundation
Co-I: (PI: Murray) Mapping and Monitoring the Global Burden of Antimicrobial Resistance; Fleming Fund, Wellcome Trust, BMGF
Co-I: (PI: Bacci) Community Pharmacist Population Health Management of People Living with Epilepsy; UCB Pharma
Co-I: (PI: Baeten) Pharmacy Delivery to Expand the Reach of PrEP in Kenya; NIH-NIMH (R34)
Co-I: (PI: Ho) Washington Entrepreneurial Research Evaluation and Commercialization Hub; NIH/NHLBI
Co-I: (PI: Farquhar) Health-Professional Education Partnership Initiative (HEPI) – Kenya; NIH/Fogarty

Sean Sullivan
Consortium PI: Comparative Effectiveness of CSF; A Pragmatic Trial to Improve Colony Stimulating Factor Use in Cancer; Fred Hutchinson Cancer Research Center, 2016-2021
PI, PCOR K12: Mentored Career Development Program in Patient-Centered Outcomes Research; AHRQ, 2012 – 2019
Co-Director: Pacific Northwest Evidence-Based Practice Center; AHRQ, 2012 – 2017
Co-Investigator: PTN ON (PI David Flum) Practice Transformation Network; CMS, 2017-2018

David Veenstra
PI: Fellowships in HEOR. Genentech, Inc., 07/01/2018 – 06/30/2021
Site PI: Rational Integration of clinical SEquencing (RISE); Vanderbilt University Medical Center, 09/05/2017 – 07/31/2021
Co-I: (PI: Thummel) Program on Genetic and Dietary Predictors of Drug Response in Rural and AI/AN; NIH                   08/01/2017-07/31/2021
Co-I: (PI: Bansal) Personalized Risk-Adaptive Surveillance strategies in Cancer (PRAISE); NIH, 07/01/2018-06/30/2023
Co-I: (PI: Devine) Cancer Health Assessment Reaching Many (CHARM); Kaiser Foundation Research Institute, 06/01/2018 – 05/31/2021
Co-I: (PI: Jarvik) Evolving Our Partnership: The CSER2 Centralized Support Coordinating Center (CSER2 Coord Center); NIH, 04/01/2013 – 06/30/2021
Co-I: (PI: Jarvik) The Electronic Medical Records and Genomics (eMERGE) Network, Phase III; Kaiser Foundation Health Plan of WA, 04/25/2019 – 03/31/2020

Davene Wright
PI, Leveraging Incentives for Obesity Prevention, American Heart Association, 2016-2018