Publications

Farooq M, Kelly EJ, Unadkat JD.
CYP2D6 is inducible by endogenous and exogenous corticosteroids.
Drug Metab Dispos. 2016 Mar 10. pii: dmd.115.069229. [Epub ahead of print]

Zhang Z, Farooq M, Prasad B, Grepper S, Unadkat JD.
Prediction of gestational age-dependent induction of in vivo hepatic CYP3A activity based on HepaRG cells and human hepatocytes.
Drug Metab Dispos. 2015 Jun;43(6):836-42.

Mao Q, Unadkat JD.
Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport–an update.
AAPS J. 2015 Jan;17(1):65-82.

Zhang Y, Wang H, Unadkat JD, Mao Q.
Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse. Drug Metab Dispos. 2007, 35(12):2154-8.

Unadkat JD , Wara DW, Hughes MD, Mathias AA, Holland DT, Paul ME, Connor J, Huang S, Nguyen BY, Watts DH, Mofenson LM, Smith E, Deutsch P, Kaiser KA, Tuomala RE.
Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women. Antimicrob Agents Chemother. 2007, 51(2):783-6.

Hebert M, Easterling T, Kirby B, Carr D, Buchanan M, Rutherford T, Thummel K, Fishbein D, Unadkat J.
Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study. Clin Pharmacol Ther. 2008, 84(2):248-53.

Wang H, Lee EW, Zhou L, Leung PC, Ross DD, Unadkat JD, Mao Q.
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. Mol Pharmacol. 2008, 73(3):845-54.

Zhou L, Naraharisetti SB, Wang H, Unadkat JD, Hebert MF, Mao Q.
The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study. Mol Pharmacol. 2008, 73(3):949-59.

Zhang H, Wu X, Wang H, Mikheev AM, Mao Q, Unadkat JD.
Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course. Mol Pharmacol. 2008, 74(3):714-23.

Dickmann LJ, Tay S, Senn TD, Zhang H, Visone A, Unadkat JD, Hebert MF, Isoherranen N.
Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Biochem Pharmacol. 2008, 75(8):1677-87.

Zhou L, Zhang Y, Hebert MF, Unadkat JD, Mao Q.
Increased glyburide clearance in the pregnant mouse model. Drug Metab Dispos. 2010, 38(9):1403-6.

Ke AB, Nallani SC, Zhao P, Rostami-Hodjegan A, Unadkat JD.
A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction. CPT Pharmacometrics Syst Pharmacol. 2012, 1:e3.

Papageorgiou I, Grepper S, Unadkat JD.
Induction of Hepatic CYP3A Enzymes by Pregnancy-Related Hormones: Studies in Human Hepatocytes and Hepatic Cell Lines. Drug Metab Dispos. 2013, 41(2):281-90.

Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J.
Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metab Dispos. 2013, 41(12):2225-32.

Dickmann LJ, Isoherranen N.
Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy. Drug Metab Dispos. 2013, 41(2):270-4.

Topletz AR, Le HN, Lee N, Chapman JD, Kelly EJ, Wang J, Isoherranen N.
Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy. Drug Metab Dispos. 2013, 41(2):312-9.

Isoherranen N , Thummel KE.
Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes? Drug Metab Dispos. 2013, 41(2):256-62.

Koh KH, Pan X, Shen HW, Arnold SL, Yu AM, Gonzalez FJ, Isoherranen N, Jeong H.
Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Biol Chem. 2013, [Epub ahead of print]

Shuster DL, Bammler TK, Beyer RP, Macdonald JW, Tsai JM, Farin FM, Hebert MF, Thummel KE, Mao Q.
Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice. Drug Metab Dispos. 2013, 41(2):332-42.