Anoshchenko O, Storelli F, Unadkat JD.
Successful Prediction of Human Fetal Exposure to P-Glycoprotein Substrate Drugs Using the Proteomics-Informed Relative Expression Factor Approach and PBPK Modeling and Simulation. Drug Metab Dispos. 2021 Oct;49(10):919-928. doi: 10.1124/dmd.121.000538. Epub 2021 Aug 23. PMID: 34426410; PMCID: PMC8626637.
Anoshchenko O, Milad MA, Unadkat JD.
Estimating fetal exposure to the P-gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome. CPT Pharmacometrics Syst Pharmacol. 2021 Sep;10(9):1057-1070. doi: 10.1002/psp4.12674. Epub 2021 Jul 23. PMID: 34273255; PMCID: PMC8452292.
Fay EE, Czuba LC, Sager JE, Shum S, Stephenson-Famy A, Isoherranen N.
Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites. Ther Drug Monit. 2021 Dec 1;43(6):780-788. doi: 10.1097/FTD.0000000000000885. PMID: 33814540; PMCID: PMC8426418.
Peng J, Ladumor MK, Unadkat JD.
Prediction of Pregnancy-Induced Changes in Secretory and Total Renal Clearance of Drugs Transported by Organic Anion Transporters. Drug Metab Dispos. 2021 Oct;49(10):929-937. doi: 10.1124/dmd.121.000557. Epub 2021 Jul 27. PMID: 34315779; PMCID: PMC8626639.
Shum S, Shen DD, Isoherranen N.
Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling. Drug Metab Dispos. 2021 Nov;49(11):1003-1015. doi: 10.1124/dmd.121.000612. Epub 2021 Aug 18. PMID: 34407992.
Chen X, Unadkat JD, Mao Q.
Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2). Drug Metab Dispos. 2021 Oct;49(10):910-918. doi: 10.1124/dmd.121.000505. Epub 2021 Jul 29. PMID: 34326138; PMCID: PMC8626638.
Patilea-Vrana GI, Unadkat JD.
Development and Verification of a Linked Δ9-THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women. Drug Metab Dispos. 2021 Jul;49(7):509-520. doi: 10.1124/dmd.120.000322. Epub 2021 May 5. PMID: 33952608; PMCID: PMC8313051.
Cox EJ, Tian DD, Clarke JD, Rettie AE, Unadkat JD, Thummel KE, McCune JS, Paine MF.
Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach. Pharmacol Rev. 2021 Apr;73(2):847-859. doi: 10.1124/pharmrev.120.000106. PMID: 33712517; PMCID: PMC7956993.
Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ.
Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. Sci Rep. 2021 Nov 1;11(1):21356. doi: 10.1038/s41598-021-00338-y. PMID: 34725352; PMCID: PMC8560754.
Shum S, Isoherranen N.
Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7. AAPS J. 2021 Jan 12;23(1):24. doi: 10.1208/s12248-020-00537-x. PMID: 33438174; PMCID: PMC8106324.
Han LW, Wang L, Shi Y, Dempsey JL, Pershutkina OV, Dutta M, Bammler TK, Cui JY, Mao Q.
Impact of Microbiome on Hepatic Metabolizing Enzymes and Transporters in Mice during Pregnancy. Drug Metab Dispos. 2020 Aug;48(8):708-722. doi: 10.1124/dmd.120.000039. Epub 2020 Jun 4. PMID: 32499338; PMCID: PMC7434050.
Huang W, Isoherranen N.
Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption. CPT Pharmacometrics Syst Pharmacol. 2020 Oct;9(10):571-583. doi: 10.1002/psp4.12553. Epub 2020 Sep 25. PMID: 32977369; PMCID: PMC7577018.
Bansal S, Maharao N, Paine MF, Unadkat JD.
Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450. Drug Metab Dispos. 2020 Oct;48(10):1008-1017. doi: 10.1124/dmd.120.000073. Epub 2020 Jun 25. PMID: 32587099; PMCID: PMC7543485.
Anoshchenko O, Prasad B, Neradugomma NK, Wang J, Mao Q, Unadkat JD.
Gestational Age-Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics. Drug Metab Dispos. 2020 Sep;48(9):735-741. doi: 10.1124/dmd.120.000067. Epub 2020 Jun 26. Erratum in: Drug Metab Dispos. 2020 Dec;48(12):1347. PMID: 32591415; PMCID: PMC7469251.
Han LW, Shi Y, Paquette A, Wang L, Bammler TK, Mao Q.
Key hepatic metabolic pathways are altered in germ-free mice during pregnancy. PLoS One. 2021 Mar 12;16(3):e0248351. doi: 10.1371/journal.pone.0248351. PMID: 33711049; PMCID: PMC7954286.
Huang W, Czuba LC, Manuzak JA, Martin JN, Hunt PW, Klatt NR, Isoherranen N.
Objective Identification of Cannabis Use Levels in Clinical Populations Is Critical for Detecting Pharmacological Outcomes. Cannabis Cannabinoid Res. 2021 Nov 18. doi: 10.1089/can.2021.0068. Epub ahead of print. PMID: 34793254.