Course Listings

See UW course catalog for course descriptions.

Autumn Quarter

MEDCH 400 Fundamental Concepts in Medicinal Chemistry
Principles of physical organic chemistry; chemical bonding, stereochemistry, acids/bases, and reaction mechanisms relevant to processes such as drug distribution, specificity, and metabolism. Prerequisite: either CHEM 239 or CHEM 337. Offered: A.

MEDCH 495 Special Studies in Medicinal Chemistry
Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 499 Undergrad Research
Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.

MEDCH 520 Seminar
Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with PCEUT 520.

MEDCH 551 Flavin and Heme-Containing Monooxygenases
Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 552 Drug Action and Drug Metabolism
Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 553 Structure and Function of Macromolecular Protein Assemblies
Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 554 Biophysical and Structural Virology
Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Credit/no-credit only. Offered: AWSpS.

MEDCH 555 Biophysics and Pharmacology of Dynamic Proteins
Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 556 Clinical and Mechanistic Aspects of Drug Metabolism
Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 558 Human Cytochrome P-450 Biochemistry
Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 559 Biosynthesis, Metabolism, and Analysis of Lipids
Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 562 Medicinal Chemistry
Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: A.

Link to course website

MEDCH 582 Topics in Medicinal Chemistry (Monday Night Meeting)
Discussion of pertinent articles from current literature. Credit/no-credit only. Offered: AWSp.

Link to course website

MEDCH 599 Cumulative Exams for Medicinal Chemistry
Quarterly cumulative examinations for graduate students. Credit/no-credit only. Offered: AWSp.

MEDCH 600 Independent Study or Research
Credit/no-credit only. Offered: AWSpS.

MEDCH 700 Masters Thesis
Credit/no-credit only. Offered: AWSpS.

MEDCH 800 Doctoral Dissertation
Credit/no-credit only. Offered: AWSpS.

Winter Quarter

MEDCH 495 Special Studies in Medicinal Chemistry
Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 499 Undergrad Research
Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.
MEDCH 520 Seminar
Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with PCEUT 520.
MEDCH 527 Drug Metabolism
Considerations of the biochemical mechanisms for the biotransformation of drugs and foreign compounds. Includes reaction mechanisms, ultrastructural considerations,induction mechanisms, methodology, kinetics of inhibition and activation, steroid and amine metabolism. Offered: jointly with PHCOL 527; W, odd years.

Link to course website

MEDCH 528 Biophysical Enzymology and Biopharmaceuticals
The first part of the course includes in-depth treatment of thermodynamics and kinetics of protein-ligand interactions, protein-protein interactions and protein-lipid interactions. The second part of the course includes theoretical and practical aspects of biophysical methods not covered in most other courses, including surface plasmon resonance, scanning and titrating calorimetry, and other specialized methods with particular utility in modern drug discovery. The third part of this course provides examples of theory and methods from the first two parts, with particular emphasis on therapeutic proteins discussed, including viruses, therapeutic antibodies, Fc-fusion proteins, and drug targets. Students are responsible for all of the material presented in the lecture notes, the classroom lectures and, in addition, any reading material assigned by the instructors. Students will directly interact with industry scientists with expertise in biophysical analysis. Offered: W, even years.

Link to course website

MEDCH 529 Advanced Medicinal Chemistry
Covers the fundamental aspects of contemporary medicinal chemistry. Discusses the chemical characteristics of drugs and drug targets, pharmaceutical properties of drugs, drug metabolism, toxicology, and pharmacogenetics. Focuses on various drug classes; their biochemistry, pharmacology, mechanism of action, and toxicology. Offered: W.

Link to Course Website

MEDCH 535 Diagnostic Medicinal Chemistry
Examination of clinical diagnostic tests with regard to the chemical or biochemical rationale of the testing method, interpretation of test results, and major factors influencing test values with special emphasis on the effects of medications. Clinical laboratory data from patients considered in light of these factors. Offered: Not offered 2018.

MEDCH 551 Flavin and Heme-Containing Monooxygenases
Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 552 Drug Action and Drug Metabolism
Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 553 Structure and Function of Macromolecular Protein Assemblies
Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 554 Biophysical and Structural Virology
Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Credit/no-credit only. Offered: AWSpS.
MEDCH 555 Biophysics and Pharmacology of Dynamic Proteins
Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 556 Clinical and Mechanistic Aspects of Drug Metabolism
Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 558 Human Cytochrome P-450 Biochemistry
Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 559 Biosynthesis, Metabolism, and Analysis of Lipids
Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 563 Medicinal Chemistry
Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: W.
MEDCH 570 Medicinal Biochemistry
Covers advanced topics in medical biochemistry directly related to understanding disease and drug therapy in pharmacy practice. Areas of study include enzymes of drug metabolism, metabolic control of disease states, signal transduction, virology, coagulation and complement cascades, cellular transport, and DNA replication/transcription. Offered: W.

Link to course website

MEDCH 582 Topics in Medicinal Chemistry (Monday Night Meeting)
Discussion of pertinent articles from current literature. Credit/no-credit only. Offered: AWSp.

Link to course website

MEDCH 599 Cumulative Exams for Medicinal Chemistry
Quarterly cumulative examinations for graduate students. Credit/no-credit only. Offered: AWSp.

MEDCH 600 Independent Study or Research
Credit/no-credit only. Offered: AWSpS.

MEDCH 800 Doctoral Dissertation

Spring Quarter

MEDCH 495 Special Studies in Medicinal Chemistry
Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 499 Undergrad Research
Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.
MEDCH 520 Seminar
Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with PCEUT 520.
MEDCH 521 Advanced Medicinal Chemistry
Application of integrated data from the physical and biological sciences to problems of chemotherapy, including transport of drugs to site of action, biotransformation of drugs, interaction of drugs with enzyme systems, and recent advances in drug design. Prerequisite: CHEM 457, CHEM 531, and BIOC 442, or permission of instructor. Offered: Sp.

MEDCH 530 Integrated Pharmacology
Students present and discuss primary literature that integrates aspects of medicinal chemistry and pharmacokinetics with the physiology, pharmacology, and genetics of therapeutic drug targets. Examples of targets discussed include ion channels and enzymes relevant to cardiovascular disease, and neurodegenerative disease. Credit/no-credit only. Offered: Sp.

MEDCH 541 Biological Mass Spectrometry
Covers the basics of modern ionization methods and mass analyzers; small molecule structure assignment, quantitative assay development by LC-MS and metabolomics; quantitative discovery-based proteomics and validation methods; and peptide sequence determination, post-translational modification mapping, and protein structure determination methods. Prerequisite: permission of instructor. Offered: Sp.

MEDCH 551 Flavin and Heme-Containing Monooxygenases
Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 552 Drug Action and Drug Metabolism
Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 553 Structure and Function of Macromolecular Protein Assemblies
Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 554 Biophysical and Structural Virology
Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Credit/no-credit only. Offered: AWSpS.

MEDCH 555 Biophysics and Pharmacology of Dynamic Proteins
Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 556 Clinical and Mechanistic Aspects of Drug Metabolism
Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 558 Human Cytochrome P-450 Biochemistry
Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 559 Biosynthesis, Metabolism, and Analysis of Lipids
Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

MEDCH 561 Immunizing and Antimicrobial Agents
Mechanisms of action, spectrum of coverage, resistance patterns, toxicity, and therapeutic applications of antibiotics, antifungals, and antivirals. Also covering chemical and biologic properties of agents used to prevent or treat infectious diseases, including diagnostic, prophylactic, and therapeutic uses of immunizing agents. Prerequisite: MICROM 301, MICROM 302, MEDCH 570, or equivalent, PharmD major, or permission of instructor. Offered: Sp.

Link to course website

MEDCH 564 Medicinal Chemistry
Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: Sp.

MEDCH 582 Topics in Medicinal Chemistry (Monday Night Meeting)
Discussion of pertinent articles from current literature. Credit/no-credit only. Offered: AWSp.

Link to course website

MEDCH 599 Cumulative Exams for Medicinal Chemistry
Quarterly cumulative examinations for graduate students. Credit/no-credit only. Offered: AWSp.
MEDCH 600 Independent Study and Research
Credit/no-credit only. Offered: AWSpS.
MEDCH 700 Masters Thesis
Credit/no-credit only. Offered: AWSpS.
MEDCH 800 Doctoral Dissertation
Credit/no-credit only. Offered: AWSpS.

Summer Quarter

MEDCH 495 Special Studies in Medicinal Chemistry
Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 499 Undergrad Research
Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.
MEDCH 551 Flavin and Heme-Containing Monooxygenases
Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 552 Drug Action and Drug Metabolism
Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 553 Structure and Function of Macromolecular Protein Assemblies
Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 554 Biophysical and Structural Virology
Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Credit/no-credit only. Offered: AWSpS.
MEDCH 555 Biophysics and Pharmacology of Dynamic Proteins
Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 556 Clinical and Mechanistic Aspects of Drug Metabolism
Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 558 Human Cytochrome P-450 Biochemistry
Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 559 Biosynthesis, Metabolism, and Analysis of Lipids
Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MEDCH 600 Independent Study and Research
Credit/no-credit only. Offered: AWSpS.
MEDCH 700 Masters Thesis
Credit/no-credit only. Offered: AWSpS.
MEDCH 800 Doctoral Dissertation
Credit/no-credit only. Offered: AWSpS.