October 31, 2016

Med Chem & Pharmaceutics faculty, alumni well-represented at MDO Symposium

Guoying Tai, Allan Rettie, and Leslie Dickmann

Guoying Tai, Allan Rettie, and Leslie Dickmann at MDO 2016 at UC Davis Conference Center

The University of Washington was well-represented at the 21st International Symposium on Microsomes & Drug Oxidations (MDO) held at UC Davis from October 2-6, 2016. Our faculty and alumni researchers presented drug metabolism and related area research during the Parallel Symposia:

  • Allan Rettie* (UW Medicinal Chemistry) – CYP2C9 and 4F gene variation in warfarin response & drug interactions
  • Bhagwat Prasad (UW Pharmaceutics) – CES1 and CES2: Distribution, function and clinical significance
  • Joanne Wang (UW Pharmaceutics) – Importance of OCTs in drug transport
  • Nina Isoherranen* (UW Pharmaceutics) – Translation of in vitro biochemical data of vitamin A and retinoid metabolism to tissue specific changes in retinoid concentrations and signaling
  • Curtis Klaassen and Julia Yue Cui (UW Environmental and Occupational Health Sciences) – RNA-Seq Quantification of Hepatic Drug-Processing Genes in Germ-Free Mice
  • Jeff Jones (UW Medicinal Chemistry ’87, WSU, Chemistry Faculty) – Direct Observation of Cytochrome P450 and Cytochrome P450 Reductase Interacting with Lipid Bilayers
  • Cyrus Khojasteh (UW Medicinal Chemistry ’98, Genetech, Drug Metabolism & Pharmacokinetics Associate Director and Senior Scientist) – Current understanding and challenges in the determination of ADME of ADCs

*Session Co-Chair

Other UW School of Pharmacy Alumni present:

Guoying Tai (UW Medicinal Chemistry ’06) – GlaxoSmithKline, Preclinical Drug Metabolism and Pharmacokinetics

Leslie Dickmann (UW Medicinal Chemistry ’03) – Genetech, Preclinical and Translation Pharmacokinetics

John Harrelson (UW Medicinal Chemistry ’05) – Pacific University, School of Pharmacy

Jed Lampe (UW Medicinal Chemistry ’07) – KU Medical Center, Pharmacology, Toxicology & Therapeutics

Clara Hsia (UW Medicinal Chemistry ’12) – Vertex Pharmaceuticals

Kayte Edson (UW Medicinal Chemistry ’13) – Amgen, PKDM

Brooke Rock (UW Medicinal Chemistry ’10) – Amgen, PKDM

Aiming Yu (UW Medicinal Chemistry ’98) was the Chair of the MOC that organized the 21st MDO international conference at UC Davis.  Dr. Yu, Associate Professor in the UC Davis Dept of Biochemistry and Molecular Medicine, also directs the PK/PD Bioanalytical Core Facility at UC Davis.

The Keynote LectureMechanism-Based Inactivation of Human Cytochrome P450s” was given by Larry Wienkers (UW Medicinal Chemistry ’93), Vice President at Amgen.

Conference resources:

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