Publications

Structural dynamics reveal subtype-specific activation and inhibition of influenza virus hemagglutinin. Garcia NK, Kephart SM, Benhaim MA, Matsui T, Mileant A, Guttman M, Lee KK. J Biol Chem. 2023 Jun;299(6):104765. doi: 10.1016/j.jbc.2023.104765. Epub 2023 Apr 28.

Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses. McLeod B, Mabrouk MT, Miura K, Ravichandran R, Kephart S, Hailemariam S, Pham TP, Semesi A, Kucharska I, Kundu P, Huang WC, Johnson M, Blackstone A, Pettie D, Murphy M, Kraft JC, Leaf EM, Jiao Y, van de Vegte-Bolmer M, van Gemert GJ, Ramjith J, King CR, MacGill RS, Wu Y, Lee KK, Jore MM, King NP, Lovell JF, Julien JP. Immunity. 2022 Sep 13;55(9):1680-1692.e8. doi: 10.1016/j.immuni.2022.07.015. Epub 2022 Aug 16.

Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env. Hodge EA, Naika GS, Kephart SM, Nguyen A, Zhu R, Benhaim MA, Guo W, Moore JP, Hu SL, Sanders RW, Lee KK. iScience. 2022 May 23;25(6):104449. doi: 10.1016/j.isci.2022.104449. eCollection 2022 Jun 17.

Structure-based design of stabilized recombinant influenza neuraminidase tetramers. Ellis D, Lederhofer J, Acton OJ, Tsybovsky Y, Kephart S, Yap C, Gillespie RA, Creanga A, Olshefsky A, Stephens T, Pettie D, Murphy M, Sydeman C, Ahlrichs M, Chan S, Borst AJ, Park YJ, Lee KK, Graham BS, Veesler D, King NP, Kanekiyo M. Nat Commun. 2022 Apr 5;13(1):1825. doi: 10.1038/s41467-022-29416-z.

Quadrivalent influenza nanoparticle vaccines induce broad protection. Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M. Nature. 2021 Apr;592(7855):623-628. doi: 10.1038/s41586-021-03365-x. Epub 2021 Mar 24.

Structural changes of Zn(II)bleomycin complexes when bound to DNA hairpins containing the 5′-GT-3′ and 5′-GC-3′ binding sites studied through NMR spectroscopy. Follett SE, Murray SA, Ingersoll AD, Reilly TM, Lehmann TE. Magnetochemistry. 2018;4(1). pii: 4. doi: 10.3390/magnetochemistry4010004. Epub 2017 Dec 27.

Interaction of Zn(II)bleomycin-A2 and Zn(II)peplomycin with a DNA hairpin containing the 5′-GT-3′ binding site in comparison with the 5′-GC-3′ binding site studied by NMR spectroscopy. Follett SE, Ingersoll AD, Murray SA, Reilly TM, Lehmann TE. J Biol Inorg Chem. 2017 Oct;22(7):1039-1054. doi: 10.1007/s00775-017-1482-z. Epub 2017 Jul 26.

NMR study of the effects of some bleomycin C-termini on the structure of a DNA hairpin with the 5′-GC-3′ binding site. Lehmann TE, Murray SA, Ingersoll AD, Reilly TM, Follett SE, Macartney KE, Harpster MH. J Biol Inorg Chem. 2017 Jan;22(1):121-136. doi: 10.1007/s00775-016-1413-4. Epub 2016 Nov 17.