
Ryan Seguin
Research Scientist
Department of Medicinal Chemistry, Medicinal Chemistry Research Staff, Xu Lab
Email: rps87@uw.edu
Research Scientist
Department of Medicinal Chemistry, Medicinal Chemistry Research Staff, Xu Lab
Email: rps87@uw.edu
Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern. Environ Sci Technol. 2023 May 23;57(20):7645-7665. doi: 10.1021/acs.est.2c08244. Epub 2023 May 8.
High-Throughput Measurement and Machine Learning-Based Prediction of Collision Cross Sections for Drugs and Drug Metabolites. J Am Soc Mass Spectrom. 2022 Jun 1;33(6):1061-1072. doi: 10.1021/jasms.2c00111. Epub 2022 May 11.
Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate. Front Immunol. 2020 Oct 21;11:575179. doi: 10.3389/fimmu.2020.575179. eCollection 2020. PMID: 33193366
Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450. Chem Res Toxicol. 2019 Dec 16;32(12):2466-2478. doi: 10.1021/acs.chemrestox.9b00293. Epub 2019 Dec 3.PMID: 31730751
Characterization of the Impact of Drug Metabolism on the Gas-Phase Structures of Drugs Using Ion Mobility-Mass Spectrometry. Anal Chem. 2019 Nov 19;91(22):14498-14507. doi: 10.1021/acs.analchem.9b03292. Epub 2019 Oct 29.PMID: 31613088
Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain. Toxicol Sci. 2019 Jun 14;171(1):32-45. doi: 10.1093/toxsci/kfz139. Online ahead of print.PMID: 31199489