Publications

Examining the Nephrotoxicity Induced by Benzalkonium Chlorides in 2D and 3D-Cultured Human Proximal Tubule Epithelial Cells Brzoska M, Seguin RP, Yang J, Kelly E, Xu L. J Pharmacol Exp Ther. 2025 Mar, Volume 392, Issue 3, doi: 10.1016/j.jpet.2024.101674

Respective Roles of CYP4F2 and CYP2D6 in the Formation of Even- and Odd-Carbon Carboxylic Acid Metabolites of Benzalkonium Chloride in Human Hepatocytes  Zhu L, Seguin RP, Xu L. J Pharmacol Exp Ther. 2025 Mar, Volume 392, Issue 3, doi: 10.1016/j.jpet.2024.101708

Interaction of Benzalkonium Chlorides with CYP168A1 of Pseudomonas aeruginosa Seguin RP, Kandel SE, Lampe JN, Xu L. J Pharmacol Exp Ther. 2025 Mar, Volume 392, Issue 3, doi: 10.1016/j.jpet.2025.103508

Interaction and Transport of Benzalkonium Chlorides by the Organic Cation and Multidrug and Toxin Extrusion Transporters. Vieira LS, Seguin RP, Xu L, Wang J.Drug Metab Dispos. 2024 Mar 13;52(4):312-321. doi: 10.1124/dmd.123.001625.

Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern. Arnold WA, Blum A, Branyan J, Bruton TA, Carignan CC, Cortopassi G, Datta S, DeWitt J, Doherty AC, Halden RU, Harari H, Hartmann EM, Hrubec TC, Iyer S, Kwiatkowski CF, LaPier J, Li D, Li L, Muñiz Ortiz JG, Salamova A, Schettler T, Seguin RP, Soehl A, Sutton R, Xu L, Zheng G.Environ Sci Technol. 2023 May 23;57(20):7645-7665. doi: 10.1021/acs.est.2c08244. Epub 2023 May 8.

High-Throughput Measurement and Machine Learning-Based Prediction of Collision Cross Sections for Drugs and Drug Metabolites. Ross DH, Seguin RP, Krinsky AM, Xu L.J Am Soc Mass Spectrom. 2022 Jun 1;33(6):1061-1072. doi: 10.1021/jasms.2c00111. Epub 2022 May 11.

Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure. Hrubec TC, Seguin RP, Xu L, Cortopassi GA, Datta S, Hanlon AL, Lozano AJ, McDonald VA, Healy CA, Anderson TC, Musse NA, Williams RT.Toxicol Rep. 2021 Mar 9;8:646-656. doi: 10.1016/j.toxrep.2021.03.006. eCollection 2021.

Development and Application of a Peroxyl Radical Clock Approach for Measuring Both Hydrogen-Atom Transfer and Peroxyl Radical Addition Rate Constants. Do Q, Lee DD, Dinh AN, Seguin RP, Zhang R, Xu L. J Org Chem. 2021 Jan 1;86(1):153-168. doi: 10.1021/acs.joc.0c01920. Epub 2020 Dec 3.

Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate. Abdelhamid L, Cabana-Puig X, Mu Q, Moarefian M, Swartwout B, Eden K, Das P, Seguin RP, Xu L, Lowen S, Lavani M, Hrubec TC, Jones CN, Luo XM. Front Immunol. 2020 Oct 21;11:575179. doi: 10.3389/fimmu.2020.575179. eCollection 2020. 

Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450. Seguin RP, Herron JM, Lopez VA, Dempsey JL, Xu L. Chem Res Toxicol. 2019 Dec 16;32(12):2466-2478. doi: 10.1021/acs.chemrestox.9b00293. Epub 2019 Dec 3.

Characterization of the Impact of Drug Metabolism on the Gas-Phase Structures of Drugs Using Ion Mobility-Mass Spectrometry. Ross DH, Seguin RP, Xu L. Anal Chem. 2019 Nov 19;91(22):14498-14507. doi: 10.1021/acs.analchem.9b03292. Epub 2019 Oct 29.

Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain. Herron JM, Hines KM, Tomita H, Seguin RP, Cui JY, Xu L. Toxicol Sci. 2019 Jun 14;171(1):32-45. doi: 10.1093/toxsci/kfz139. Online ahead of print.

Characterization of inhibition kinetics of (S)-warfarin hydroxylation by noscapine: implications in warfarin therapy. Zhang N, Seguin RP, Kunze KL, Zhang YY, Jeong H. Drug Metab Dispos. 2013 Dec;41(12):2114-23. doi: 10.1124/dmd.113.053330. Epub 2013 Sep 17.