School of Pharmacy

Ryan Seguin

Research Scientist

Department of Medicinal Chemistry, Medicinal Chemistry Research Staff, Xu Lab

Email: rps87@uw.edu

Publications

High-Throughput Measurement and Machine Learning-Based Prediction of Collision Cross Sections for Drugs and Drug Metabolites. Ross DH, Seguin RP, Krinsky AM, Xu L. J Am Soc Mass Spectrom. 2022 Jun 1;33(6):1061-1072. doi: 10.1021/jasms.2c00111. Epub 2022 May 11.

Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure. Hrubec TC, Seguin RP, Xu L, Cortopassi GA, Datta S, Hanlon AL, Lozano AJ, McDonald VA, Healy CA, Anderson TC, Musse NA, Williams RT. Toxicol Rep. 2021 Mar 9;8:646-656. doi: 10.1016/j.toxrep.2021.03.006. eCollection 2021.

Development and Application of a Peroxyl Radical Clock Approach for Measuring Both Hydrogen-Atom Transfer and Peroxyl Radical Addition Rate Constants. Do Q, Lee DD, Dinh AN, Seguin RP, Zhang R, Xu L. J Org Chem. 2021 Jan 1;86(1):153-168. doi: 10.1021/acs.joc.0c01920. Epub 2020 Dec 3. PMID: 33269585

Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate. Abdelhamid L, Cabana-Puig X, Mu Q, Moarefian M, Swartwout B, Eden K, Das P, Seguin RP, Xu L, Lowen S, Lavani M, Hrubec TC, Jones CN, Luo XM. Front Immunol. 2020 Oct 21;11:575179. doi: 10.3389/fimmu.2020.575179. eCollection 2020. PMID: 33193366

Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450. Seguin RP, Herron JM, Lopez VA, Dempsey JL, Xu L. Chem Res Toxicol. 2019 Dec 16;32(12):2466-2478. doi: 10.1021/acs.chemrestox.9b00293. Epub 2019 Dec 3.PMID: 31730751

Characterization of the Impact of Drug Metabolism on the Gas-Phase Structures of Drugs Using Ion Mobility-Mass Spectrometry. Ross DH, Seguin RP, Xu L. Anal Chem. 2019 Nov 19;91(22):14498-14507. doi: 10.1021/acs.analchem.9b03292. Epub 2019 Oct 29.PMID: 31613088

Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain. Herron JM, Hines KM, Tomita H, Seguin RP, Cui JY, Xu L. Toxicol Sci. 2019 Jun 14;171(1):32-45. doi: 10.1093/toxsci/kfz139. Online ahead of print.PMID: 31199489

Characterization of inhibition kinetics of (S)-warfarin hydroxylation by noscapine: implications in warfarin therapy. Zhang N, Seguin RP, Kunze KL, Zhang YY, Jeong H. Drug Metab Dispos. 2013 Dec;41(12):2114-23. doi: 10.1124/dmd.113.053330. Epub 2013 Sep 17. PMID: 24046330