School of Pharmacy

Rheem Totah

Associate Professor, Medicinal Chemistry

Department of Medicinal Chemistry, Medicinal Chemistry Faculty, Plein Center in Geriatrics Faculty, School Faculty, Totah Lab

Telephone: (206) 543-9481

Email: rtotah@uw.edu

Website: Totah Lab

Education

  • B.S. (Honors), 1995, Birzeit University, Palestine
  • Masters (Honors), 2000, University of Kansas
  • Ph.D. (Honors), 2002, University of Kansas

Research Interests

  • Prescription drug negative side effects in the heart, skeletal muscle and bone; associated chemical mechanisms for this toxicity
  • Drug-endogenous substrate interactions
  • Pharmacogenetics

Taking Students: Yes

Biography

Dr. Totah obtained her bachelor’s degree in chemistry from Birzeit University in Palestine and her master’s and PhD in medicinal chemistry from the University of Kansas. Dr. Totah is currently an associate professor in the Department of Medicinal Chemistry. Her research is in the area of prescription drug negative side effects especially in the heart, skeletal muscle and bone. She focuses on researching the chemical mechanisms for this toxicity. Her research is important in guiding research towards medicines with fewer side effects and safer use. Research in the Totah lab is broadly centered on drug-endogenous substrate interactions.

Recent Publications

Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study. Lemaitre RN, Jensen PN, Zeigler M, Denham J, Fretts AM, Umans JG, Howard BV, Sitlani CM, McKnight B, Gharib SA, King IB, Siscovick DS, Psaty BM, Sotoodehnia N, Totah RA. EBioMedicine. 2021 Apr;66:103279. doi: 10.1016/j.ebiom.2021.103279. Epub 2021 Mar 19.

Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril. Maldonato BJ, Russell DA, Totah RA. Sci Rep. 2021 Mar 1;11(1):4857. doi: 10.1038/s41598-021-84218-5.

Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy. Somani ST, Zeigler M, Fay EE, Leahy M, Bermudez B, Totah RA, Hebert MF. Life Sci. 2021 Jan 1;264:118590. doi: 10.1016/j.lfs.2020.118590. Epub 2020 Oct 15.

Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human. Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B. Mol Pharm. 2020 Nov 2;17(11):4114-4124. doi: 10.1021/acs.molpharmaceut.0c00559. Epub 2020 Oct 2.

Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors. Evangelista EA, Cho CW, Aliwarga T, Totah RA. Front Pharmacol. 2020 Jun 9;11:828. doi: 10.3389/fphar.2020.00828. eCollection 2020.

Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling. Aliwarga T, Guo X, Evangelista EA, Lemaitre RN, Sotoodehnia N, Gharib SA, Zeldin DC, Liu Q, Totah RA. Biomedicines. 2020 May 30;8(6):144. doi: 10.3390/biomedicines8060144.

CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes. Evangelista EA, Aliwarga T, Sotoodehnia N, Jensen PN, McKnight B, Lemaitre RN, Totah RA, Gharib SA. Sci Rep. 2020 Mar 24;10(1):5329. doi: 10.1038/s41598-020-62174-w.

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. Kahma H, Filppula AM, Launiainen T, Viinamäki J, Neuvonen M, Evangelista EA, Totah RA, Backman JT. Drug Metab Dispos. 2019 Apr;47(4):436-443. doi: 10.1124/dmd.118.085498. Epub 2019 Feb 1.

Full PubMed Listing