Michael Dabrowski

Research Scientist

Atkins Lab, Department of Medicinal Chemistry , Medicinal Chemistry Research Staff

Telephone: (206) 616-2781

Email: dabrowsk@uw.edu

Publications

Stereoselective effects of 4-hydroxynonenal in cultured mouse hepatocytes. Dabrowski MJ, Zolnerciks JK, Balogh LM, Greene RJ, Kavanagh TJ, Atkins WM. Chem Res Toxicol. 2010 Oct 18;23(10):1601-7. doi: 10.1021/tx100190k. Epub 2010 Sep 28.

Flow cytometric analysis of BDE 47 mediated injury to rainbow trout gill epithelial cells. Shao J, Dabrowski MJ, White CC, Kavanagh TJ, Gallagher EP. Aquat Toxicol. 2010 Apr 1;97(1):42-50. doi: 10.1016/j.aquatox.2009.11.013. Epub 2009 Dec 11.

The role of mitochondrial and oxidative injury in BDE 47 toxicity to human fetal liver hematopoietic stem cells. Shao J, White CC, Dabrowski MJ, Kavanagh TJ, Eckert ML, Gallagher EP. Toxicol Sci. 2008 Jan;101(1):81-90. Epub 2007 Oct 4.

Over expression of glutamate cysteine ligase increases cellular resistance to H2O2-induced DNA single-strand breaks. Shi S, Hudson FN, Botta D, McGrath MB, White CC, Neff-LaFord HD, Dabrowski MJ, Singh NP, Kavanagh TJ. Cytometry A. 2007 Sep;71(9):686-92.

Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice. Botta D, Shi S, White CC, Dabrowski MJ, Keener CL, Srinouanprachanh SL, Farin FM, Ware CB, Ladiges WC, Pierce RH, Fausto N, Kavanagh TJ. J Biol Chem. 2006 Sep 29;281(39):28865-75. Epub 2006 Jul 13.

Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin. Dabrowski MJ, Maeda D, Zebala J, Lu WD, Mahajan S, Kavanagh TJ, Atkins WM. Arch Biochem Biophys. 2006 May 15;449(1-2):94-103. Epub 2006 Mar 3.

NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity. Roberts AG, Díaz MD, Lampe JN, Shireman LM, Grinstead JS, Dabrowski MJ, Pearson JT, Bowman MK, Atkins WM, Campbell AP. Biochemistry. 2006 Feb 14;45(6):1673-84.

The central loop of Escherichia coli glutamine synthetase is flexible and functionally passive. Pearson JT, Dabrowski MJ, Kung I, Atkins WM. Arch Biochem Biophys. 2005 Apr 15;436(2):397-405.

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis. Botta D, Franklin CC, White CC, Krejsa CM, Dabrowski MJ, Pierce RH, Fausto N, Kavanagh TJ. Free Radic Biol Med. 2004 Sep 1;37(5):632-42.

Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. Dabrowski MJ, Schrag ML, Wienkers LC, Atkins WM. J Am Chem Soc. 2002 Oct 9;124(40):11866-7.