Libin Xu

Assistant Professor

Department of Medicinal Chemistry, Medicinal Chemistry Faculty , Xu Lab

Telephone: (206) 543-1080

Email: libinxu@uw.edu

Website: Lab site

Expertise: Central Nervous System, Cytochrome P450, Lipid Metabolism, Mass Spectrometry, Neurodevelopmental Disease, Toxicology

Education

  • Postdoctoral training, Vanderbilt University
  • Ph.D. in Organic Chemistry, University of Illinois at Chicago
  • B.Sc. in Chemistry, Nankai University

Research Interests

  • Mechanisms and products of lipid oxidation
  • Cholesterol biosynthesis disorders, in particular, Smith-Lemli-Opitz syndrome
  • Effect of drugs on lipid metabolism
  • Metabolomics and Lipidomics using ion mobility-mass spectrometry
  • Lipid metabolism in neurodevelopment
  • Antibiotic resistance

Biography

Dr. Xu was trained as an organic chemist early in his career, but during his postdoctoral training at Vanderbilt University, his research expanded to chemistry and biology of lipid peroxidation underlying human diseases, as well as mass spectrometry-based lipidomics.

The Xu lab is interested in the consequences of unusual lipid metabolism and oxidation processes on the nervous system, which could result from genetic mutations or small molecule interference. The lab aims to develop interventions that could ameliorate or reverse the adverse effects of the disrupted lipid homeostasis and oxidized lipids. The Xu lab is also interested in elucidating the contribution of altered lipid metabolism to antibiotic resistance in bacterial pathogens using mass spectrometry and molecular biology methodologies, aiming to develop strategies to re-sensitize the resistant bacteria.

Dr. Xu is the recipient of the NIH Pathway to Independence Award from NICHD in 2012 and the Young Investigator Award from the Society for Free Radical Biology and Medicine in 2011. He is also the inaugural recipient, together with Prof. Brian Werth, of the School of Pharmacy Faculty Innovation Fund in 2016.

 

Recent Publications