Kimberly M. Alonge

Assistant Professor, Medicinal Chemistry & DOM Division of Metabolism, Endocrinology, and Nutrition; Program Director for Matrix Biology at the UW Medicine Diabetes Institute

Alonge Lab, Department of Medicinal Chemistry, Medicinal Chemistry Faculty, Plein Center for Aging Faculty, School Faculty

Telephone: 206-685-3543

Email: kalonge@uw.edu

Expertise:
Central Nervous System, Diabetes, Extracellular Matrices, Geriatrics, Glycobiology, Laser Capture Microdissection, Mass Spectrometry, Neurodegeneration, Neurodevelopmental Disease, Neuroscience, Nutrition, Obesity and Bariatric Surgery, Pregnancy and Fetal Pharmacology, Translational Research

Taking Students: Yes

Education

  • B.S. (Biology), Salisbury University
  • Ph.D. (Biochemistry and Molecular Biology), West Virginia University School of Medicine
  • Postdoc (UW Medicine Diabetes Institute, School of Medicine, Division of Metabolism, Endocrinology and Nutrition), University of Washington

Research Interests

  • Perineuronal net reorganization
  • Chondroitin and heparan sulfate glycosaminoglycan sulfation patterning
  • Glycan sequencing technology
  • Obesity, diabetes, Alzheimer’s disease, neuropsychiatric disorders

Recent Publications

Characterizing the human intestinal chondroitin sulfate glycosaminoglycan sulfation signature in inflammatory bowel disease. Francis KL, Zheng HB, Suskind DL, Murphree TA, Phan BA, Quah E, Hendrickson AS, Zhou X, Nuding M, Hudson AS, Guttman M, Morton GJ, Schwartz MW, Alonge KM, Scarlett JM. Sci Rep. 2024 May 23;14(1):11839. doi: 10.1038/s41598-024-60959-x. PMID: 38782973

Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species. Hendrickson AS, Francis KL, Kumar A, Le JP, Scarlett JM, Keene CD, Tovar DA, Alonge KM. Front Neurosci. 2024 Apr 30;18:1396101. doi: 10.3389/fnins.2024.1396101. eCollection 2024. PMID: 38745932

Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate. Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S, Alonge KM, Pearce OMT.Cancer Res Commun. 2024 Apr 3;4(4):970-985. doi: 10.1158/2767-9764.CRC-23-0548. PMID:38517140

Perineuronal net deglycosylation associates with tauopathy-induced gliosis and neurodegeneration. Logsdon AF, Foresi B, Hu SJ, Quah E, Meuret CJ, Le JP, Hendrickson AS, Redford IK, Kumar A, Phan BA, Doan TP, Noonan C, Hendricks NE, Wheeler JM, Kraemer BC, Alonge KM. J Neurochem. 2024 Feb 5. doi: 10.1111/jnc.16067. Online ahead of print. PMID: 38317026

Inter-alpha-trypsin inhibitor (IαI) and hyaluronan modifications enhance the innate immune response to influenza virus in the lung. Tang F, Reeves SR, Brune JE, Chang MY, Chan CK, Waldron P, Drummond SP, Milner CM, Alonge KM, Garantziotis S, Day AJ, Altemeier WA, Frevert CW. Matrix Biol. 2024 Feb;126:25-42. doi: 10.1016/j.matbio.2024.01.004. Epub 2024 Jan 15. PMID: 38232913

Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity. Francis KL, Alonge KM, Pacheco MC, Hu SJ, Krutzsch CA, Morton GJ, Schwartz MW, Scarlett JM. World J Gastroenterol. 2023 Sep 7;29(33):4991-5004. doi: 10.3748/wjg.v29.i33.4991.

Distinct Roles for Brain and Pancreas in Basal and Postprandial Glucose Homeostasis. Alonge KM, Porte D, Schwartz MW. Diabetes. 2023 May 1;72(5):547-556. doi: 10.2337/db22-0969.

The “Loss” of Perineuronal Nets in Alzheimer’s Disease: Missing or Hiding in Plain Sight? Scarlett JM, Hu SJ, Alonge KM. Front Integr Neurosci. 2022 May 25;16:896400. doi: 10.3389/fnint.2022.896400. eCollection 2022.

Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma. Alonge KM, Herbert MJ, Yagi M, Cook DG, Banks WA, Logsdon AF. Front Behav Neurosci. 2021 Oct 28;15:745288. doi: 10.3389/fnbeh.2021.745288. eCollection 2021.

Decoding perineuronal net glycan sulfation patterns in the Alzheimer’s disease brain. Logsdon AF, Francis KL, Richardson NE, Hu SJ, Faber CL, Phan BA, Nguyen V, Setthavongsack N, Banks WA, Woltjer RL, Keene CD, Latimer CS, Schwartz MW, Scarlett JM, Alonge KM. Alzheimers Dement. 2022 May;18(5):942-954. doi: 10.1002/alz.12451.

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizu T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. Cell Rep. 2021 Jul 13;36(2):109362. doi: 10.1016/j.celrep.2021.109362.

Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes. Alonge KM, D’Alessio DA, Schwartz MW. Diabetologia. 2021 Jan;64(1):5-14. doi: 10.1007/s00125-020-05293-3. Epub 2020 Oct 12.

(Correction to: Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.  Alonge KM, D’Alessio DA, Schwartz MW. Diabetologia. 2021 Jan;64(1):259. doi: 10.1007/s00125-020-05321-2.)

Rapid Differentiation of Chondroitin Sulfate Isomers by Gas-phase Hydrogen-deuterium Exchange. Alonge KM, Harkewicz R, Guttman M. Curr Mol Med. 2020;20(10):821-827. doi: 10.2174/1566524020666200915110707.

Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats. Alonge KM, Mirzadeh Z, Scarlett JM, Logsdon AF, Brown JM, Cabrales E, Chan CK, Kaiyala KJ, Bentsen MA, Banks WA, Guttman M, Wight TN, Morton GJ, Schwartz MW. Nat Metab. 2020 Oct;2(10):1025-1033. doi: 10.1038/s42255-020-00275-6. Epub 2020 Sep 7.

Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission. Bentsen MA, Rausch DM, Mirzadeh Z, Muta K, Scarlett JM, Brown JM, Herranz-Pérez V, Baquero AF, Thompson J, Alonge KM, Faber CL, Kaiyala KJ, Bennett C, Pyke C, Ratner C, Egerod KL, Holst B, Meek TH, Kutlu B, Zhang Y, Sparso T, Grove KL, Morton GJ, Kornum BR, García-Verdugo JM, Secher A, Jorgensen R, Schwartz MW, Pers TH. Nat Commun. 2020 Sep 7;11(1):4458. doi: 10.1038/s41467-020-17720-5.

Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Han CY, Kang I, Harten IA, Gebe JA, Chan CK, Omer M, Alonge KM, den Hartigh LJ, Gomes Kjerulf D, Goodspeed L, Subramanian S, Wang S, Kim F, Birk DE, Wight TN, Chait A. Cell Rep. 2020 Jun 30;31(13):107818. doi: 10.1016/j.celrep.2020.107818.

Quantitative analysis of chondroitin sulfate disaccharides from human and rodent fixed brain tissue by electrospray ionization-tandem mass spectrometry. Alonge KM, Logsdon AF, Murphree TA, Banks WA, Keene CD, Edgar JS, Whittington D, Schwartz MW, Guttman M. Glycobiology. 2019 Nov 20;29(12):847-860. doi: 10.1093/glycob/cwz060.

Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus. Mirzadeh Z, Alonge KM, Cabrales E, Herranz-Pérez V, Scarlett JM, Brown JM, Hassouna R, Matsen ME, Nguyen HT, Garcia-Verdugo JM, Zeltser LM, Schwartz MW. Nat Metab. 2019 Feb;1(2):212-221. doi: 10.1038/s42255-018-0029-0. Epub 2019 Jan 21.

Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4. Alonge KM, Meares GP, Hillgartner FB. J Biol Chem. 2017 Mar 31;292(13):5239-5252. doi: 10.1074/jbc.M116.762922. Epub 2017 Feb 10.

Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism. Cyphert HA, Alonge KM, Ippagunta SM, Hillgartner FB. PLoS One. 2014 Apr 14;9(4):e94996. doi: 10.1371/journal.pone.0094996. eCollection 2014.