
Kimberly M. Alonge
Assistant Professor, Medicinal Chemistry & DOM Division of Metabolism, Endocrinology, and Nutrition; Program Director for Matrix Biology at the UW Medicine Diabetes Institute
Alonge Lab, Department of Medicinal Chemistry, Medicinal Chemistry Faculty, Plein Center for Aging Faculty, School Faculty
Telephone: 206-685-3543
Email: kalonge@uw.edu
Taking Students: Yes
Education
- B.S. (Biology), Salisbury University
- Ph.D. (Biochemistry and Molecular Biology), West Virginia University School of Medicine
- Postdoc (UW Medicine Diabetes Institute, School of Medicine, Division of Metabolism, Endocrinology and Nutrition), University of Washington
Research Interests
- Perineuronal net reorganization
- Chondroitin and heparan sulfate glycosaminoglycan sulfation patterning
- Glycan sequencing technology
- Obesity, diabetes, Alzheimer’s disease, neuropsychiatric disorders
Recent Publications
A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia. Scarlett JM, Hwang E, Richardson NE, Bryan CL, Redford I, Quah E, Odderson ETR, Choi PP, Hwang MK, Phan BA, Kadlec K, Alonge KM, Morton GJ, Williams KW, Schwartz MW. Mol Metab. 2025 Apr 4:102138. doi: 10.1016/j.molmet.2025.102138. Online ahead of print.
Neurocircuit regeneration by extracellular matrix reprogramming.Su S, Levasseur IN, Alonge KM.Neural Regen Res. 2025 Aug 1;20(8):2300-2301. doi: 10.4103/NRR.NRR-D-24-00506. Epub 2024 Sep 6.
Chondroitin sulfate glycan sulfation patterns influence histochemical labeling of perineuronal nets: a comparative study of interregional distribution in human and mouse brain. Belliveau C, Théberge S, Netto S, Rahimian R, Fakhfouri G, Hosdey C, Davoli MA, Hendrickson A, Hao K, Giros B, Turecki G, Alonge KM, Mechawar N.Glycobiology. 2024 Jun 22;34(8):cwae049. doi: 10.1093/glycob/cwae049.
Characterizing the human intestinal chondroitin sulfate glycosaminoglycan sulfation signature in inflammatory bowel disease.Francis KL, Zheng HB, Suskind DL, Murphree TA, Phan BA, Quah E, Hendrickson AS, Zhou X, Nuding M, Hudson AS, Guttman M, Morton GJ, Schwartz MW, Alonge KM, Scarlett JM.Sci Rep. 2024 May 23;14(1):11839. doi: 10.1038/s41598-024-60959-x.
Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species. Front Neurosci. 2024 Apr 30;18:1396101. doi: 10.3389/fnins.2024.1396101. eCollection 2024. PMID: 38745932
Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate. Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S, Alonge KM, Pearce OMT.Cancer Res Commun. 2024 Apr 3;4(4):970-985. doi: 10.1158/2767-9764.CRC-23-0548. PMID:38517140
Perineuronal net deglycosylation associates with tauopathy-induced gliosis and neurodegeneration. J Neurochem. 2024 Feb 5. doi: 10.1111/jnc.16067. Online ahead of print. PMID: 38317026
Inter-alpha-trypsin inhibitor (IαI) and hyaluronan modifications enhance the innate immune response to influenza virus in the lung. Matrix Biol. 2024 Feb;126:25-42. doi: 10.1016/j.matbio.2024.01.004. Epub 2024 Jan 15. PMID: 38232913
Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity. World J Gastroenterol. 2023 Sep 7;29(33):4991-5004. doi: 10.3748/wjg.v29.i33.4991.
Distinct Roles for Brain and Pancreas in Basal and Postprandial Glucose Homeostasis. Alonge KM, Porte D, Schwartz MW. Diabetes. 2023 May 1;72(5):547-556. doi: 10.2337/db22-0969.
The “Loss” of Perineuronal Nets in Alzheimer’s Disease: Missing or Hiding in Plain Sight? Front Integr Neurosci. 2022 May 25;16:896400. doi: 10.3389/fnint.2022.896400. eCollection 2022.
Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma. Front Behav Neurosci. 2021 Oct 28;15:745288. doi: 10.3389/fnbeh.2021.745288. eCollection 2021.
Decoding perineuronal net glycan sulfation patterns in the Alzheimer’s disease brain. Alzheimers Dement. 2022 May;18(5):942-954. doi: 10.1002/alz.12451.