
Kimberly M. Alonge
Assistant Professor, Medicinal Chemistry & DOM Division of Metabolism, Endocrinology, and Nutrition; Program Director for Matrix Biology at the UW Medicine Diabetes Institute
Alonge Lab, Department of Medicinal Chemistry, Medicinal Chemistry Faculty, School Faculty
Telephone: 206-685-3543
Email: kalonge@uw.edu
Taking Students: Yes
Education
- B.S. (Biology), Salisbury University
- Ph.D. (Biochemistry and Molecular Biology), West Virginia University School of Medicine
- Postdoc (UW Medicine Diabetes Institute, School of Medicine, Division of Metabolism, Endocrinology and Nutrition), University of Washington
Research Interests
- Perineuronal net reorganization
- Chondroitin and heparan sulfate glycosaminoglycan sulfation patterning
- Glycan sequencing technology
- Obesity, diabetes, Alzheimer’s disease, neuropsychiatric disorders
Recent Publications
The “Loss” of Perineuronal Nets in Alzheimer’s Disease: Missing or Hiding in Plain Sight? Front Integr Neurosci. 2022 May 25;16:896400. doi: 10.3389/fnint.2022.896400. eCollection 2022.
Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma. Front Behav Neurosci. 2021 Oct 28;15:745288. doi: 10.3389/fnbeh.2021.745288. eCollection 2021.
Decoding perineuronal net glycan sulfation patterns in the Alzheimer’s disease brain. Alzheimers Dement. 2022 May;18(5):942-954. doi: 10.1002/alz.12451.
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021 Jul 13;36(2):109362. doi: 10.1016/j.celrep.2021.109362.
Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes. Diabetologia. 2021 Jan;64(1):5-14. doi: 10.1007/s00125-020-05293-3. Epub 2020 Oct 12.
(Correction to: Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes. Diabetologia. 2021 Jan;64(1):259. doi: 10.1007/s00125-020-05321-2.)
Rapid Differentiation of Chondroitin Sulfate Isomers by Gas-phase Hydrogen-deuterium Exchange. Curr Mol Med. 2020;20(10):821-827. doi: 10.2174/1566524020666200915110707.
Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats. Nat Metab. 2020 Oct;2(10):1025-1033. doi: 10.1038/s42255-020-00275-6. Epub 2020 Sep 7.
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission. Nat Commun. 2020 Sep 7;11(1):4458. doi: 10.1038/s41467-020-17720-5.
Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Cell Rep. 2020 Jun 30;31(13):107818. doi: 10.1016/j.celrep.2020.107818.
Quantitative analysis of chondroitin sulfate disaccharides from human and rodent fixed brain tissue by electrospray ionization-tandem mass spectrometry. Glycobiology. 2019 Nov 20;29(12):847-860. doi: 10.1093/glycob/cwz060.
Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus. Nat Metab. 2019 Feb;1(2):212-221. doi: 10.1038/s42255-018-0029-0. Epub 2019 Jan 21.
Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4. J Biol Chem. 2017 Mar 31;292(13):5239-5252. doi: 10.1074/jbc.M116.762922. Epub 2017 Feb 10.
Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism. PLoS One. 2014 Apr 14;9(4):e94996. doi: 10.1371/journal.pone.0094996. eCollection 2014.