Danny Shen

Professor

Department of Pharmaceutics, Department of Pharmacy , OPRU , Pharmaceutics Faculty , Pharmacy Faculty

Telephone: (206) 685-2920

Fax: (206) 543-3835

Email: ds@uw.edu

Office Location: H375 HSB Box 357630

Website: PubMed

Expertise: Central Nervous System, Cytochrome P450, Drug Interactions, Herbal Medicines, Pharmacokinetics/Pharmacodynamics

Education

  • PhD in Pharmaceutics, State University of New York at Buffalo
  • BA in Chemistry and Biology, Luther College

Research Interests

  • Metabolically based drug-drug and herb-drug interactions with a focus on intestinal and hepatic CYPs
  • Pharmacokinetics and pharmacodynamics of opioid analgesics in special populations
  • Microphysiological system for in vitro modeling of drug excretion by the kidneys in health and chronic kidney diseases

Courses Taught

  • Pceut 531P: Pharmaceutical Formulation: Principles and Dosage Forms
  • Pceut 510: Pharmacokinetics of Drug Interactions
  • Pceut 506: Pharmacokinetic Principles
  • Pceut 503: Drug Transport & Delivery

Biography

Dr. Shen is a professor in the Departments of Pharmaceutics and Pharmacy, and a past chair of the Department of Pharmacy. He is a Member in the Clinical Research Division at Fred Hutchinson Cancer Research Center and a Co-Director of the Pharmacokinetics Lab, a shared research resource for UW Health Sciences. Shen held faculty appointments at the University of Kansas Medical Center and State University of New York at Buffalo prior to joining the faculty at the University of Washington in 1984. Shen is a fellow of the American Association of Pharmaceutical Scientists (AAPS) and the American Association for the Advancement of Science (AAAS).

Shen is a past president of AAPS. He is also a member of several other scientific societies, including the American Society of Pharmacology and Experimental Therapeutics (ASPET) and the American Society of Clinical Pharmacology and Therapeutics (ASCPT). He is on the editorial board of the “Journal of Pharmaceutical Sciences,” “AAPS Journal,” and “Pharmaceutical Research.” He has served as adviser or consultant to governmental agencies (e.g. National Institutes of Health, Food and Drug Administration) and the pharmaceutical industry.

Selected Publications

Yeung CK, Billings FT 4th, Claessens AJ, Roshanravan B, Linke L, et al. Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress. BMC nephrology. 2015; 16:183. PMID: 26531095, PMCID: PMC4630830

Ryu RJ, Eyal S, Easterling TR, Caritis SN, Venkataraman R, et al. Pharmacokinetics of metoprolol during pregnancy and lactation. Journal of clinical pharmacology. 2015; PMID: 26461463

McAdams RM, McPherson RJ, Kapur R, Phillips B, Shen DD, et al. Dexmedetomidine reduces cranial temperature in hypothermic neonatal rats. Pediatric research. 2015; 77(6):772-8. PMID: 25751572

Chan LN, Lin YS, Tay-Sontheimer JC, Trawick D, Oelschlager BK, et al. Proximal Roux-en-Y gastric bypass alters drug absorption pattern but not systemic exposure of CYP3A4 and P-glycoprotein substrates. Pharmacotherapy. 2015; 35(4):361-9. PMID: 25757445, PMCID: PMC4696861

Chapron B, Risler L, Phillips B, Collins C, Thummel K, et al. Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. Journal of pharmacy & pharmaceutical sciences. 2015; 18(1):101-11. PMID: 25877445