Publications

Fibertools: fast and accurate DNA-m6A calling using single-molecule long-read sequencing. Jha A, Bohaczuk SC, Mao Y, Ranchalis J, Mallory BJ, Min AT, Hamm MO, Swanson E, Finkbeiner C, Li T, Whittington D, Noble WS, Stergachis AB, Vollger MR. bioRxiv. 2023 Jul 6:2023.04.20.537673. doi: 10.1101/2023.04.20.537673. Preprint.
Correction to: How Does the Public Evaluate Vaccines for Low‑Incidence, Severe‑Outcome Diseases? A General‑Population Choice Experiment.

Reed Johnson F, Fairchild A, Whittington D, Srivastava AK, Gonzalez JM, Huang L. Patient. 2023 May;16(3):287. doi: 10.1007/s40271-023-00620-3.
The Effects of Pregnancy on Amino Acid Levels and Nitrogen Disposition. Enthoven LF, Shi Y, Fay EE, Moreni S, Mao J, Honeyman EM, Smith CK, Whittington D, Brockerhoff SE, Isoherranen N, Totah RA, Hebert MF. Metabolites. 2023 Feb 7;13(2):242. doi: 10.3390/metabo13020242.
Do Extremely Low Gestational Age Neonates Regulate Iron Absorption via Hepcidin? German KR, Comstock BA, Parikh P, Whittington D, Mayock DE, Heagerty PJ, Bahr TM, Juul SE. J Pediatr. 2022 Feb;241:62-67.e1. doi: 10.1016/j.jpeds.2021.09.059. Epub 2021 Oct 7.
Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes. Nakamura K, Neidig LE, Yang X, Weber GJ, El-Nachef D, Tsuchida H, Dupras S, Kalucki FA, Jayabalu A, Futakuchi-Tsuchida A, Nakamura DS, Marchianò S, Bertero A, Robinson MR, Cain K, Whittington D, Tian R, Reinecke H, Pabon L, Knollmann BC, Kattman S, Thies RS, MacLellan WR, Murry CE. Stem Cell Reports. 2021 Oct 12;16(10):2473-2487. doi: 10.1016/j.stemcr.2021.08.005. Epub 2021 Sep 9.
Repeated isolation of an antibiotic-dependent and temperature-sensitive mutant of Pseudomonas aeruginosa from a cystic fibrosis patient. Wolter DJ, Scott A, Armbruster CR, Whittington D, Edgar JS, Qin X, Buccat AM, McNamara S, Blackledge M, Waalkes A, Salipante SJ, Ernst RK, Hoffman LR. J Antimicrob Chemother. 2021 Feb 11;76(3):616-625. doi: 10.1093/jac/dkaa482.
Risk of Breast Cancer Associated with Estrogen DNA Adduct Biomarker. Reding KW, Han CJ, Whittington D, Zahid M, Rogan EG, Langford D, Rohan TE, Chlebowski RT, Cheng TD, Barrington WE, Tinker LF. Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):2096-2099. doi: 10.1158/1055-9965.EPI-20-0133. Epub 2020 Jul 22.
Structure-Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates. Kowalski JP, McDonald MG, Whittington D, Guttman M, Scian M, Girhard M, Hanenberg H, Wiek C, Rettie AE. Chem Res Toxicol. 2019 Dec 16;32(12):2488-2498. doi: 10.1021/acs.chemrestox.9b00330. Epub 2019 Dec 4.

Quantitative analysis of chondroitin sulfate disaccharides from human and rodent fixed brain tissue by electrospray ionization-tandem mass spectrometry. Alonge KM, Logsdon AF, Murphree TA, Banks WA, Keene CD, Edgar JS, Whittington D, Schwartz MW, Guttman M. Glycobiology. 2019 Jul 30. pii: cwz060. doi: 10.1093/glycob/cwz060. [Epub ahead of print]

Sex Hormones in Women With Elevated Breast Cancer Risk Undergoing Weight Loss. Stone SA, Han CJ, Senn T, Korde LA, Allott K, Reding S, Whittington D, Reding KW. West J Nurs Res. 2019 Jan 7:193945918820672. doi: 10.1177/0193945918820672. [Epub ahead of print]

Glycan targeted polymeric antibiotic prodrugs for alveolar macrophage infections. Chen J, Su FY, Das D, Srinivasan S, Son HN, Lee B, Radella F 2nd, Whittington D, Monroe-Jones T, West TE, Convertine AJ, Skerrett SJ, Stayton PS, Ratner DM. Biomaterials. 2019 Mar;195:38-50. doi: 10.1016/j.biomaterials.2018.10.017. Epub 2018 Oct 16.

Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol. Teitelbaum AM, McDonald MG, Kowalski JP, Parkinson OT, Scian M, Whittington D, Roellecke K, Hanenberg H, Wiek C, Rettie AE. J Pharmacol Exp Ther. 2019 Feb;368(2):308-316. doi: 10.1124/jpet.118.249771. Epub 2018 Nov 8.

A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma. Zeigler M, Whittington D, Sotoodehnia N, Lemaitre RN, Totah RA. Chem Phys Lipids. 2018 Sep 7. pii: S0009-3084(18)30082-3. doi: 10.1016/j.chemphyslip.2018.09.004. [Epub ahead of print]

Fast and sensitive HPLC-MS/MS method for direct quantification of intracellular deoxyribonucleoside triphosphates from tissue and cells.  Olafsson S, Whittington D, Murray J, Regnier M, Moussavi-Harami F. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:90-97. doi: 10.1016/j.jchromb.2017.10.008. Epub 2017 Oct 5.

Fatty-acyl chain profiles of cellular phosphoinositides. Traynor-Kaplan A, Kruse M, Dickson EJ, Dai G, Vivas O, Yu H, Whittington D, Hille B. Biochim Biophys Acta. 2017 May;1862(5):513-522. doi: 10.1016/j.bbalip.2017.02.002. Epub 2017 Feb 9.

Corrigendum to “Simultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC-MS/MS assay” [J. Chromatogr. B 1025 (2016) 110-118]. Blakney AK, Jiang Y, Whittington D, Woodrow KA.  J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 15;1039:88. doi: 10.1016/j.jchromb.2016.10.022. Epub 2016 Nov 9. No abstract available.

Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE.  Drug Metab Dispos. 2016 Oct;44(10):1598-602. doi: 10.1124/dmd.116.070003. Epub 2016 Jul 28.

Simultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC-MS/MS assay. Blakney AK, Jiang Y, Whittington D, Woodrow KA.  J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 1;1025:110-8. doi: 10.1016/j.jchromb.2016.04.048. Epub 2016 May 2.

Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis. Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK. J Am Soc Mass Spectrom. 2016 Apr;27(4):662-8. doi: 10.1007/s13361-015-1330-8. Epub 2016 Jan 26.

Sphingosine, a modulator of human translesion DNA polymerase activity. Kamath-Loeb AS, Balakrishna S, Whittington D, Shen JC, Emond MJ, Okabe T, Masutani C, Hanaoka F, Nishimura S, Loeb LA.  J Biol Chem. 2014 Aug 1;289(31):21663-72. doi: 10.1074/jbc.M114.570242. Epub 2014 Jun 13.

PhoPQ regulates acidic glycerophospholipid content of the Salmonella Typhimurium outer membrane. Dalebroux ZD, Matamouros S, Whittington D, Bishop RE, Miller SI.  Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1963-8. doi: 10.1073/pnas.1316901111. Epub 2014 Jan 21.

The long-term dynamics of mortality benefits from improved water and sanitation in less developed countries. Jeuland MA, Fuente DE, Ozdemir S, Allaire MC, Whittington D. PLoS One. 2013 Oct 8;8(10):e74804. doi: 10.1371/journal.pone.0074804. eCollection 2013.

Effect of travel distance on household demand for typhoid vaccines: implications for planning. Kim D, Lauria DT, Poulos C, Dong B, Whittington D.  Int J Health Plann Manage. 2014 Jul-Sep;29(3):e261-76. doi: 10.1002/hpm.2172. Epub 2013 Mar 12.

Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2343-52. doi: 10.1073/pnas.1206701109. Epub 2012 Jul 25.

Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Xing J, Kirby BJ, Whittington D, Wan Y, Goodlett DR.  Drug Metab Dispos. 2012 Sep;40(9):1757-64. doi: 10.1124/dmd.112.045765. Epub 2012 Jun 7.

Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). Kharasch ED, Bedynek PS, Hoffer C, Walker A, Whittington D. Anesthesiology. 2012 Feb;116(2):432-47. doi: 10.1097/ALN.0b013e3182423478.

Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Drug Metab Dispos. 2012 Mar;40(3):610-6. doi: 10.1124/dmd.111.042705. Epub 2011 Dec 21.

Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. Kirby BJ, Collier AC, Kharasch ED, Dixit V, Desai P, Whittington D, Thummel KE, Unadkat JD.  Drug Metab Dispos. 2011 Dec;39(12):2329-37. doi: 10.1124/dmd.111.038646. Epub 2011 Sep 19.

Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Drug Metab Dispos. 2011 Jun;39(6):1070-8. doi: 10.1124/dmd.110.037523. Epub 2011 Mar 15.

Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal. Shireman LM, Kripps KA, Balogh LM, Conner KP, Whittington D, Atkins WM.  Arch Biochem Biophys. 2010 Dec 15;504(2):182-9. doi: 10.1016/j.abb.2010.09.005. Epub 2010 Sep 15.