Dale Whittington

Manager, Tech Director

Department of Medicinal Chemistry, Mass Spectrometry Center , Medicinal Chemistry Research Staff

Telephone: (206) 543-6439

Email: dalewhit@uw.edu

Publications

Zeigler M, Whittington D, Sotoodehnia N, Lemaitre RN, Totah RA. A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma. Chem Phys Lipids. 2018 Sep 7. pii: S0009-3084(18)30082-3. doi: 10.1016/j.chemphyslip.2018.09.004. [Epub ahead of print]

Olafsson S, Whittington D, Murray J, Regnier M, Moussavi-Harami F. Fast and sensitive HPLC-MS/MS method for direct quantification of intracellular deoxyribonucleoside triphosphates from tissue and cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:90-97. doi: 10.1016/j.jchromb.2017.10.008. Epub 2017 Oct 5.

Traynor-Kaplan A, Kruse M, Dickson EJ, Dai G, Vivas O, Yu H, Whittington D, Hille B. Fatty-acyl chain profiles of cellular phosphoinositides. Biochim Biophys Acta. 2017 May;1862(5):513-522. doi: 10.1016/j.bbalip.2017.02.002. Epub 2017 Feb 9.

Blakney AK, Jiang Y, Whittington D, Woodrow KA. Corrigendum to “Simultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC-MS/MS assay” [J. Chromatogr. B 1025 (2016) 110-118]. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 15;1039:88. doi: 10.1016/j.jchromb.2016.10.022. Epub 2016 Nov 9. No abstract available.

Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metab Dispos. 2016 Oct;44(10):1598-602. doi: 10.1124/dmd.116.070003. Epub 2016 Jul 28.

Blakney AK, Jiang Y, Whittington D, Woodrow KA. Simultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC-MS/MS assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 1;1025:110-8. doi: 10.1016/j.jchromb.2016.04.048. Epub 2016 May 2.

Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK. Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis. J Am Soc Mass Spectrom. 2016 Apr;27(4):662-8. doi: 10.1007/s13361-015-1330-8. Epub 2016 Jan 26.

Kamath-Loeb AS, Balakrishna S, Whittington D, Shen JC, Emond MJ, Okabe T, Masutani C, Hanaoka F, Nishimura S, Loeb LA. Sphingosine, a modulator of human translesion DNA polymerase activity. J Biol Chem. 2014 Aug 1;289(31):21663-72. doi: 10.1074/jbc.M114.570242. Epub 2014 Jun 13.

Dalebroux ZD, Matamouros S, Whittington D, Bishop RE, Miller SI. PhoPQ regulates acidic glycerophospholipid content of the Salmonella Typhimurium outer membrane. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1963-8. doi: 10.1073/pnas.1316901111. Epub 2014 Jan 21.

Jeuland MA, Fuente DE, Ozdemir S, Allaire MC, Whittington D. The long-term dynamics of mortality benefits from improved water and sanitation in less developed countries. PLoS One. 2013 Oct 8;8(10):e74804. doi: 10.1371/journal.pone.0074804. eCollection 2013.

Kim D, Lauria DT, Poulos C, Dong B, Whittington D. Effect of travel distance on household demand for typhoid vaccines: implications for planning. Int J Health Plann Manage. 2014 Jul-Sep;29(3):e261-76. doi: 10.1002/hpm.2172. Epub 2013 Mar 12.

Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2343-52. doi: 10.1073/pnas.1206701109. Epub 2012 Jul 25.

Xing J, Kirby BJ, Whittington D, Wan Y, Goodlett DR. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metab Dispos. 2012 Sep;40(9):1757-64. doi: 10.1124/dmd.112.045765. Epub 2012 Jun 7.

Kharasch ED, Bedynek PS, Hoffer C, Walker A, Whittington D. Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). Anesthesiology. 2012 Feb;116(2):432-47. doi: 10.1097/ALN.0b013e3182423478.

Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. Drug Metab Dispos. 2012 Mar;40(3):610-6. doi: 10.1124/dmd.111.042705. Epub 2011 Dec 21.

Kirby BJ, Collier AC, Kharasch ED, Dixit V, Desai P, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. Drug Metab Dispos. 2011 Dec;39(12):2329-37. doi: 10.1124/dmd.111.038646. Epub 2011 Sep 19.

Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug Metab Dispos. 2011 Jun;39(6):1070-8. doi: 10.1124/dmd.110.037523. Epub 2011 Mar 15.

Shireman LM, Kripps KA, Balogh LM, Conner KP, Whittington D, Atkins WM. Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal. Arch Biochem Biophys. 2010 Dec 15;504(2):182-9. doi: 10.1016/j.abb.2010.09.005. Epub 2010 Sep 15.