School of Pharmacy

Abhinav Nath

Associate Professor, Medicinal Chemistry

Department of Medicinal Chemistry, Medicinal Chemistry Faculty, Nath Lab, Plein Center in Geriatrics Faculty, School Faculty

Telephone: (206) 616-4586

Email: anath@uw.edu

Website: Nath Lab

Expertise: Central Nervous System, Computational Modeling, Drug Discovery, Molecular Biophysics, Protein Dynamics

Education

  • B.A. (Chemistry and Biology), University of Virginia
  • Ph.D. (Medicinal Chemistry/Biomolecular Structure & Design), University of Washington
  • Postdoc (Molecular Biophysics & Biochemistry), Yale University

Research Interests

  • Protein aggregation in Alzheimer’s disease and related dementias
  • Protein self-assembly
  • Biologics and protein-based therapeutics

Courses Taught

  • MEDCH 501

Biography

Abhinav “Abhi” Nath earned his BA (in Biology and Chemistry) from the University of Virginia in 2003, and his PhD (in Medicinal Chemistry and Biomolecular Structure & Design) from the University of Washington in 2008, where he worked with Bill Atkins on understanding the mechanisms of substrate binding by cytochrome P450s and other drug-metabolizing enzymes. He then moved to Yale University for postdoctoral training with professors Liz Rhoades and Andrew Miranker, where he was an American Heart Association Postdoctoral Fellow and studied intrinsically disordered and amyloid-forming proteins using single-molecule fluorescence and computational methods.

The Nath lab is interested in understanding the roles of protein dynamics in human health and disease. Proteins display a fascinating spectrum of dynamic behavior, ranging from some that are almost static to others that rapidly interconvert between a diverse ensemble of structures. The nature, amplitude and timescales of protein conformational fluctuations can be crucial to biological functions such as enzyme catalysis and intracellular signaling. Mutations, post-translational modifications and environmental factors can perturb protein dynamics – and hence normal function – in ways that are difficult to predict.

Abhi and his group are developing new and powerful methods to characterize and control protein dynamics, building on recent advances in biophysics, biochemistry and pharmacology from groups around the world. They focus on proteins involved in degenerative disorders (such as Alzheimer’s disease), the oxidative stress response, and drug metabolism.

Selected Publications

http://faculty.washington.edu/anath/publications.html