Congratulations to PharmD and Pharmaceutics PhD student Lindsay Henderson who received the 2nd place graduate student poster presentation award for the Drug Metabolism and Disposition Division of ASPET (American Society for Pharmacology and Experimental Therapeutics).
Her poster titled, “Functional Characterization of Novel CYP2C9 Variants Found in an Alaska Native Population,” focuses on genetic polymorphisms in CYP2C9, an important cytochrome P450 responsible for the metabolism of medications across many therapeutic classes including non steroidal anti-inflammatories, angiotensin II blockers, as well as narrow therapeutic index drugs such as (S)-warfarin and phenytoin.
Comprehensive in vitro experiments were performed to elucidate the function of novel CYP2C9 protein variants found in an Alaska Native population.
The team’s findings suggest that carriers of the CYP2C9 N218I and M1L variant alleles would be at risk of exacerbated therapeutic effects from narrow therapeutic index drugs that rely on CYP2C9 for their metabolic clearance.
Her co-authors include UWSOP researchers, Matthew G McDonald, Catherine K Yeung, ’05, Allan E Rettie, and Kenneth E Thummel, who served as Senior Author.