Publications

Application of a substrate cocktail approach in the assessment of cytochrome P450 induction using cultured human hepatocytes. Pelletier RD, Lai WG, Wong YN. J Biomol Screen. 2013 Feb;18(2):199-210. Epub 2012 Oct 15.

Pharmacokinetic characterization of a natural product-inspired novel MEK1 inhibitor E6201 in preclinical species. Kumar V, Schuck EL, Pelletier RD, Farah N, Condon KB, Ye M, Rowbottom C, King BM, Zhang ZY, Saxton PL, Wong YN. Cancer Chemother Pharmacol. 2012 Jan;69(1):229-37. Epub 2011 Jun 23.

Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III. Shen Y, Boivin R, Yoneda N, Du H, Schiller S, Matsushima T, Goto M, Shirota H, Gusovsky F, Lemelin C, Jiang Y, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Schnaderbeck M, Wang Y. Bioorg Med Chem Lett. 2010 May 15;20(10):3155-7. Epub 2010 Mar 30.

Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II. Shen Y, Du H, Kotake M, Matsushima T, Goto M, Shirota H, Gusovsky F, Li X, Jiang Y, Schiller S, Spyvee M, Davis H, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Wang Y. Bioorg Med Chem Lett. 2010 May 15;20(10):3047-9. Epub 2010 Apr 9.

In vitro screening of metabolic clearance using two concentration points. Williams ET, Farah N, Pelletier RD, Lai WG. Drug Metab Lett. 2010 Dec;4(4):233-40.

Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead. Du H, Matsushima T, Spyvee M, Goto M, Shirota H, Gusovsky F, Chiba K, Kotake M, Yoneda N, Eguchi Y, DiPietro L, Harmange JC, Gilbert S, Li XY, Davis H, Jiang Y, Zhang Z, Pelletier R, Wong N, Sakurai H, Yang H, Ito-Igarashi H, Kimura A, Kuboi Y, Mizui Y, Tanaka I, Ikemori-Kawada M, Kawakami Y, Inoue A, Kawai T, Kishi Y, Wang Y. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6196-9. Epub 2009 Sep 3.

Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4. Zhang ZY, King BM, Pelletier RD, Wong YN. Cancer Chemother Pharmacol. 2008 Sep;62(4):707-16. Epub 2008 Apr 23.

Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells. Zhang ZY, Pelletier RD, Wong YN, Sugawara M, Zhao N, Littlefield BA. Biochem Biophys Res Commun. 2006 Mar 10;341(2):399-407. Epub 2006 Jan 11.