Nichole Klatt

Associate Professor

Department of Pharmaceutics, Pharmaceutics Faculty

Expertise: HIV and AIDS, Immunization, Infectious Diseases

Telephone: (206) 221-0254

Email: klattnr@uw.edu

Office Location: 3018 Western Ave Seattle, WA 98121

Website: PubMed

Education

  • PhD in immunology and molecular pathogenesis, Emory University
  • Bachelor of Science, University of Minnesota-Duluth

Research Interests

  • Biotherapeutics in infectious diseases and global health
  • Understanding mechanisms underlying mucosal dysfunction and development of the latent viral reservoir during HIV infection
  • Developing novel therapeutic interventions to treat HIV disease pathogenesis and prevent HIV acquisition

Biography

Dr. Klatt joined the Department of Pharmaceutics faculty as an assistant professor in 2012. The focus of her work is on biotherapeutics in infectious diseases and global health. Klatt received her PhD in immunology and molecular pathogenesis from Emory University in 2008, and she also studied as a visiting fellow at the University of Pennsylvania from 2006 to 2008.

She completed her postdoctoral training at the National Institutes of Health in 2012 in the Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases in Bethesda, Maryland. The Klatt Research Lab in the Department of Pharmaceutics focuses on better understanding the mechanisms by which HIV infection causes dysfunction of the gastrointestinal and reproductive tract immune systems. Klatt is focusing on using this knowledge to develop novel therapeutic interventions to prevent transmission of HIV and to treat HIV-associated disease.

Selected Publications

Klatt, N.R., Cheu, R., Birse, K., Zevin, A.S., Perner, M., Romas, L., Grobler, A., Westmacott, G. Xie, I.Y., Butler, J., Mansoor, L., McKinnon, L., Passmore, J., Abdool Karim, Q., Abdool Karim, S., Burgener, A.D. Vaginal Bacteria Modify HIV Tenofovir Microbicide Efficacy in African Women. Science, 2017, Jun2;356(6341):938-945. PMID: 28572388

Hensley-McBain, T., Zevin, A.S., Manuzak, J., Smith, E., Gile, J., Miller, C., Agricola, B., Katze, M., Reeves, R.K., Kraft, C.S., Langevin, S., Klatt, N.R. The effects of fecal microbial transplantation on microbiome and immunity in SIV-infected macaques. J Virol. 2016 Apr 29:90(10)4981-9. PMID 26937040.

Manuzak, J.A., Hensley-McBain, T., Zevin, A.S., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Estes J.D., Langevin, S., Reeves, R.K., Haddad, E.K., Klatt, N.R. Enhancement of microbiota in healthy macaques results in beneficial modulation of mucosal and systemic immune function. J Immunol. 2016 Jan 29. Pii:1502470. PMID 26826246.

Klatt, N.R., Canary, L.C., Sun, X., Vinton, C.L., Funderburg, N.T., Deming, C., Quinones, M. Perkins, M., Hazuda, D.J., Miller, M.D., Lederman, M.M., Segre, J.A., Lifson, J.D., Haddad, E.K., Estes, J.D., Brenchley, J.M. Probiotic and prebiotic supplementation of antiretroviral therapy improves gastrointestinal immunity in SIV-infected macaques. J Clin Invest. 2013 Jan 16. doi:pii: 66227. PMCID: PMC3561826