School of Pharmacy

Matthew McDonald

Research Scientist

Department of Medicinal Chemistry, Medicinal Chemistry Research Staff, Rettie Lab

Telephone: (206) 543-9276

Email: mcmatt@uw.edu

Publications

A new LC-MS assay for the quantitative analysis of vitamin K metabolites in human urine. McDonald MG, Yeung CK, Teitelbaum AM, Johnson AL, Fujii S, Kagechika H, Rettie AE. J Lipid Res. 2019 Apr;60(4):892-899. doi: 10.1194/jlr.D087916. Epub 2019 Jan 22.

Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol. Teitelbaum AM, McDonald MG, Kowalski JP, Parkinson OT, Scian M, Whittington D, Roellecke K, Hanenberg H, Wiek C, Rettie AE. J Pharmacol Exp Ther. 2019 Feb;368(2):308-316. doi: 10.1124/jpet.118.249771. Epub 2018 Nov 8.

Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae. McDonald MG, Ray S, Amorosi CJ, Sitko KA, Kowalski JP, Paco L, Nath A, Gallis B, Totah RA, Dunham MJ, Fowler DM, Rettie AE.Drug Metab Dispos. 2017 Dec;45(12):1364-1371. doi: 10.1124/dmd.117.078188. Epub 2017 Oct 10.

Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol intermediate. McDonald MG, Rettie AE. Chem Res Toxicol. 2007 Dec;20(12):1833-42. Epub 2007 Nov 20.

CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. McDonald MG, Rieder MJ, Nakano M, Hsia CK, Rettie AE. Mol Pharmacol. 2009 Jun;75(6):1337-46. doi: 10.1124/mol.109.054833. Epub 2009 Mar 18.

Warfarin-amiodarone drug-drug interactions: determination of [I](u)/K(I,u) for amiodarone and its plasma metabolites. McDonald MG, Au NT, Wittkowsky AK, Rettie AE. Clin Pharmacol Ther. 2012 Apr;91(4):709-17. doi: 10.1038/clpt.2011.283. Epub 2012 Mar 7.

A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites. Haque JA, McDonald MG, Kulman JD, Rettie AE. Blood. 2014 Jan 23;123(4):582-9. doi: 10.1182/blood-2013-05-505123. Epub 2013 Dec 2.

Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents. Pandey RN, Wang TS, Tadjuidje E, McDonald MG, Rettie AE, Hegde RS. PLoS One. 2013 Dec 18;8(12):e84582. doi: 10.1371/journal.pone.0084582. eCollection 2013.

Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. PLoS One. 2014 Oct 15;9(10):e110054. doi: 10.1371/journal.pone.0110054. eCollection 2014.

P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms. McDonald MG, Au NT, Rettie AE. Drug Metab Dispos. 2015 Nov;43(11):1661-9. doi: 10.1124/dmd.115.065623. Epub 2015 Aug 21.

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content. Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1.

Effect of tecarfarin, a novel vitamin K epoxide reductase inhibitor, on coagulation in beagle dogs. Choppin A, Irwin I, Lach L, McDonald MG, Rettie AE, Shao L, Becker C, Palme MP, Paliard X, Bowersox S, Dennis DM, Druzgala P. Br J Pharmacol. 2009 Nov;158(6):1536-47. doi: 10.1111/j.1476-5381.2009.00420.x. Epub 2009 Oct 20.

Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid. McDonald M, Mavrodi DV, Thomashow LS, Floss HG. J Am Chem Soc. 2001 Sep 26;123(38):9459-60. No abstract available.