Lindsay Henderson

Graduate Student

Department of Pharmaceutics, Pharmaceutics Students

Advisor – Dr. Kenneth Thummel

Year admitted: PharmD/PhD Program – 2014

Thesis: I am interested in variation in warfarin pharmacogenes and its impact on disposition and pharmacological response in the Alaska Native and American Indian populations. My project aims to establish the pharmacokinetic phenotype of several novel CYP2C9 variants that were recently identified in Alaska Native people. I am also investigating whether inheritance of CYP2C9, VKORC1, CYP4F2, CYP4F11, and GGCX gene variants in Alaska Native and American Indian people affects the dose of warfarin required to achieve a therapeutic INR.