Advisor: Dr. Ed Kelly

Admitted: 2014

Research Topic/Thesis: Antisense oligonucleotides have the potential to cause acute kidney injury and proximal tubule dysfunction.  This adverse effect  appears to be dependent on oligonucleotide chemistry.  Therefore, we are using a microphysiological model of the human proximal tubule to investigate the nephrotoxicity of antisense oligonucleotides with phosphorothioate and morpholino backbones.