Gajendra Naika

Research Scientist

Department of Medicinal Chemistry, Lee Lab , Medicinal Chemistry Research Staff

Telephone: 206-616-2811

Email: gj10@uw.edu

Publications

Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS. Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. JCI Insight. 2017 Nov 2;2(21). pii: 94929. doi: 10.1172/jci.insight.94929. [Epub ahead of print]

Nolin JD, Ogden HL, Lai Y, Altemeier WA, Frevert CW, Bollinger JG, Naika GS, Kicic A, Stick SM, Lambeau G, Henderson WR Jr, Gelb MH, Hallstrand TS. Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma. Am J Respir Cell Mol Biol. 2016 Dec;55(6):825-836.

Duchez AC, Boudreau LH, Naika GS, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, Provost P, Soulet D, Gelb MH, Boilard E. Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3564-73. doi: 10.1073/pnas.1507905112. Epub 2015 Jun 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6825. Naika, Gajendra S [added].

Rousseau M, Naika GS, Perron J, Jacques F, Gelb MH, Boilard E. Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus. PLoS One. 2015 May 13;10(5):e0126204. doi: 10.1371/journal.pone.0126204. eCollection 2015.

Guillaume C, Payré C, Jemel I, Jeammet L, Bezzine S, Naika GS, Bollinger J, Grellier P, Gelb MH, Schrével J, Lambeau G, Deregnaucourt C. In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2. Infect Immun. 2015 Jun;83(6):2453-65. doi: 10.1128/IAI.02474-14. Epub 2015 Mar 30.

Boudreau LH, Duchez AC, Cloutier N, Soulet D, Martin N, Bollinger J, Paré A, Rousseau M, Naika GS, Lévesque T, Laflamme C, Marcoux G, Lambeau G, Farndale RW, Pouliot M, Hamzeh-Cognasse H, Cognasse F, Garraud O, Nigrovic PA, Guderley H, Lacroix S, Thibault L, Semple JW, Gelb MH, Boilard E. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood. 2014 Oct 2;124(14):2173-83. doi: 10.1182/blood-2014-05-573543. Epub 2014 Jul 31.

Bollinger JG, Naika GS, Sadilek M, Gelb MH. LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity.J Lipid Res. 2013 Dec;54(12):3523-30. doi: 10.1194/jlr.D040782. Epub 2013 Aug 14. Erratum in: J Lipid Res. 2014 Mar;55(3):603. Rohan, Gajendra [corrected to Naika, Gajendra S].

Naika GS, Tiku PK. Influence of ethylenediaminetetraacetic acid (EDTA) on the structural stability of endoglucanase from Aspergillus aculeatus. J Agric Food Chem. 2011 Jul 13;59(13):7341-5. doi: 10.1021/jf103889m. Epub 2011 Jun 20.

Ghomashchi F, Naika GS, Bollinger JG, Aloulou A, Lehr M, Leslie CC, Gelb MH. Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms. J Biol Chem. 2010 Nov 12;285(46):36100-11. doi: 10.1074/jbc.M110.165647. Epub 2010 Aug 11.

Naika GS, Tiku PK. Characterization of functional intermediates of endoglucanase from Aspergillus aculeatus during urea and guanidine hydrochloride unfolding. Carbohydr Res. 2010 Jul 19;345(11):1627-31. doi: 10.1016/j.carres.2010.04.024.

Naika GS, Prakash V, Tiku PK. Effect of cosolvents on the structural stability of endoglucanase from Aspergillus aculeatus. J Agric Food Chem. 2009 Nov 11;57(21):10450-6. doi: 10.1021/jf9021724.

Naika GS, Kaul P, Prakash V. Purification and characterization of a new endoglucanase from Aspergillus aculeatus. J Agric Food Chem. 2007 Sep 5;55(18):7566-72. Epub 2007 Aug 8.