Publications

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies. Goulet DR, Orcutt SJ, Zwolak A, Rispens T, Labrijn AF, de Jong RN, Atkins WM, Chiu ML. J Biol Chem. 2018 Jan 12;293(2):651-661. Epub 2017 Nov 17.

Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding. Zwolak A, Leettola CN, Tam SH, Goulet DR, Derebe MG, Pardinas JR, Zheng S, Decker R, Emmell E, Chiu ML. Sci Rep. 2017 Nov 14;7(1):15521.

Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding. Zwolak A, Armstrong AA, Tam SH, Pardinas JR, Goulet DR, Zheng S, Brosnan K, Emmell E, Luo J, Gilliland GL, Chiu ML. MAbs. 2017 Nov/Dec;9(8):1306-1316. Epub 2017 Sep 12.

Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum. Goulet DR, Zwolak A, Chiu ML, Nath A, Atkins WM. Biochemistry. 2017 May 2;56(17):2251-2260. Epub 2017 Apr 14.