Drug Interaction Database

The Drug Interaction Database (referred to as DIDB), part of UW Drug Interaction Solutions, is designed to support research and regulatory scientists in their decision-making when evaluating PK-based drug interactions and drug safety.

The database has the largest manually curated collection of qualitative and quantitative human in vitro and in vivo information related to various extrinsic and intrinsic factors. These factors include interacting co-medications, excipients, food products, herbals, tobacco, organ impairment, and genetics, that can affect drug exposure in humans.

The information on drug disposition available in the database includes:

  • In vitro drug metabolism, drug transport and drug-drug interactions (DDIs) (involving human metabolizing enzymes, human transporters, and their variants)
  • Clinical DDIs and case reports
  • Clinical pharmacogenetics
  • Other DDI mechanisms including clinical absorption-based interactions (e.g., food effect, pH-dependence, etc.)
  • Clinical hepatic and renal impairment

The DIDB was developed 20 years ago at the University of Washington’s Department of Pharmaceutics, School of Pharmacy, with input from pre-clinical and clinical researchers in the industry. It has been licensed since 2002 and is currently used worldwide by pharmaceutical companies of all sizes, regulatory agencies, contract research organizations, academic institutions, non-profit organizations, publishers of drug information and providers of clinical decision support system.

The DIDB includes specific data and results from peer-reviewed journal articles referenced in Medline, Embase, reference textbooks, guideline documents, FDA Drug Labels, and NDA/BLA Reviews. Both in vitro and in vivo drug interaction studies are included in the database, making it useful to both pre-clinical and clinical scientists. PK profiles of drugs, QT Prolongation data, as well as Regulatory Guidances and Editorial Summaries/Syntheses can also be found.

All curation activities and editorial tasks are performed in-house by the UW Drug Interaction Solutions team that is dedicated to the database and user support.

The UW Drug Interaction Solutions team is formed of research scientists with PhD, PharmD, or MD degrees who select, analyze, and add data every day to the database.

Users can search the DIDB using a large number of queries and approach the data from many different perspectives.

Access to the DIDB is licensed as an annual subscription. Licenses are obtained via UW CoMotion’s Express License Program

For more information: www.druginteractionsolutions.org