UWRAPT relevant manuscripts

Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JOntogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics. Clin Pharmacol Ther. 100, 2016, 362. 

Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys W, Hop CE, Kumer SC, Unadkat JD. Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.  Drug Metab Dispos 44, 2016, 1752.

Wang L, Prasad B, Salphati L, Chu X, Gupta A, Hop CE, Evers R, Unadkat JD. Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey and Rat as Determined by Quantitative Proteomics. Drug Metab Dispos. 2015 (DOI: dmd.114.061580).

Kumar V, Prasad B, Patilea G, Gupta A, Salphati L, Evers R, Hop CE, Unadkat JD. Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship. Drug Metab Dispos. 43, 2015, 284.

Prasad B, Evers R, Gupta A, Hop CE, Salphati L, Shukla S, Ambudkar SV, Unadkat JD. Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: Quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Drug Metab Dispos, 42, 2014, 78.

Prasad B, Unadkat JD. Hepatic drug transporter quantification by surrogate peptide based LC-MS/MS approach: Comparison of two different internal standards, stable isotope labeled peptide (SIL) vs. stable isotope labeled protein (SILAC), Int J Proteomics, 2014, 2014: 451510.

Prasad B, Unadkat JD. Optimized practices for quantification of drug transporters in tissues and cells by LC-MS/MS, AAPS Journal, 16, 2014, 634.

Prasad B, Lai Y, Lin Y, Unadkat JD. Inter-individual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex and genotype, J Pharm Sci, 102, 2013, 787.

Deo AK, Prasad B, Balogh L, Lai Y, Unadkat JD. Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry. Drug Metab Dispos. 40, 2012, 852.


Other relevant manuscripts

Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Interindividual variability of CYP2C19-catalyzed drug metabolism due to difference in gene diplotypes and cytochrome P450 oxidoreductase content. Pharmacogenomics J. 4, 2016, 375.

Liu L, Collier AC, Link JM, Domino KB, Mankoff DA, Eary JF, Spiekerman CF, Hsiao P, Deo AK, Unadkat JD. Modulation of P-glycoprotein at the Human Blook-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study. Drug Metab Dispos. 43,  2015, 1795

Farooq M, Kelly EJ, Unadkat JD. CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug Metab Dispos. 44, 2016, 750.

Patilea-Vrana G, Unadkat JD.  Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model. Clin Pharmacol Ther. 100, 2016, 413.

Prasad B, Johnson K, Billington S, Lee CA, Chung GW, Brown CD, Kelly E, Himmelfarb J, Unadkat JD, Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics. Drug Metab Dispos.  2016 ( DOI: dmd.116.072066).

 Joshi AA, Vaidya SS, St. Pierre MV, Mikheev AM, Desino KE, Nyandege AN, Audus KL, Unadkat JD, Gerk PM. Placental ABC Transporters: Biological Impact and Pharmaceutical Significance. Pharm Res. 2016  (DOI:dmd.10.1007/s11095-016-2028-8.

 Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J. Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2-Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood Brain Barrier Drug Penetration. Drug Metab Dispos. 43, 2015, 1008. 

Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Oct 22;92(4):690-700.

Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J. Effect of gestational age on the expression of polyspecific organic cation transporters during pregnancy, Drug Metab Dispos, 41, 2014, 2225. 7.

Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE. Cytochrome P450 dependent catabolism of vitamin K: ω-Hydroxylation catalyzed by human CYP4F2 and CYP4F11, Biochemistry, 52, 2013, 8276.

Stieger B, Unadkat JD, Prasad B, Langer O, Gali H. Role of (drug) transporters in imaging in health and disease. Drug Metab Dispos. 42, 2014, 2007.

Drozdzik M, Gröer C, Penski J, Lapczuk J, Ostrowski M, Lai Y, Prasad B, Unadkat JD, Siegmund W, Oswald S. Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine. Mol Pharm., 11, 2014, 3547.