Latest Publications

RECENT FACULTY PUBLICATION HIGHLIGHTS

William Atkins, Ph.D., Professor

Goulet DR, Zwolak A, Chiu ML, Nath A, Atkins WM. Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum. Biochemistry 2017 Apr 14 doi: 10.1021/acs.biochem.6b01097 [Epub ahead of print].

McClary WD, Sumida JP, Scian M, Paco L, Atkins WM. Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs. Biochemistry 2016 Nov 15;55(45):6258-6268.

Scian M, Guttman M, Bouldin SD, Outten CE, Atkins WM. The Myeloablative Drug Busulfan Converts Cysteine to Dehydroalanine and Lanthionine in Redoxins. Biochemistry 2016 Aug 23;55(33):4720-30.

Treuheit NA, Redhair M, Kwon H, McClary WD, Guttman M, Sumida JP, Atkins WM. Membrane Interactions, Ligand-Dependent Dynamics, and Stability of Cytochrome P4503A4 in Lipid Nanodiscs. Biochemistry 2016 Feb 23;55(7):1058-69.

Scian M, Atkins WM. Supporting data for characterization of the busulfan metabolite EdAG and the Glutaredoxins that it adducts. Biochemistry 2016 Feb 23;55(7):1058-69.

Kent Kunze, Ph.D., Chair and Associate Professor

Rock BM, Hengel SM, Rock DA, Wienkers LC, Kunze KL. Characterization of ritonavir-mediated inactivation of cytochrome P450 3A4. Mol Pharmacol. 2014 Dec; 86(6):665-74.

Sager JE, Lutz JD, Foti RS, Davis C, Kunze KL, Isoherranen N. Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4. Clin Pharmacol Ther. 2014 June; 95(6):653-62.

Zhang N, Seguin RP, Kunze KL, Zhang YY, Jeong H. Characterization of inhibition kinetics of (s)-warfarin hydroxylation by noscapine: implications in warfarin therapy Drug Metab Dispos. 2013 Dec; 41(12):2114-23. doi: 10.1124/dmd.113.053330. Epub2013 Sep 17.

Lutz JD, Vandenbrink BM, Babu KN, Nelson WL, Kunze KL, Isoherranen N. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems. Drug Metab Dispos 2013 Dec; 41(12):2056-65. doi: 10.1124/dmd.113.052639. Epub 2013 Jun 19.

Kelly Lee, Ph.D., Associate Professor

Lee KK, Gui L. Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy. PLoS Pathog. 2016 Jun 30;12(6):e1005625.

Simonich CA, Williams KL, Verkerke HP, Williams JA, Nduati R, Lee KK, Overbaugh J. HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant. Cell. 2016 Jun 30;166(1):77-87.

Gui L, Ebner JL, Mileant A, Williams JA, Lee KK. Visualization and Sequencing of Membrane Remodeling Leading to Influenza Virus Fusion. J Virol. 2016 Jul 11;90(15):6948-62.

Guttman M, Lee KK. Site-Specific Mapping of Sialic Acid Linkage Isomers by Ion Mobility Spectrometry. Anal Chem. 2016 May 17;88(10):5212-7.

Abhinav Nath, Ph.D., Assistant Professor

Nath A, Schlamadinger DE, Rhoades E, Miranker AD. Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity. Biochemistry. 2015 Jun 9;54(22):3555-64.

Kumar S, Brown MA, Nath A, Miranker AD. Folded small molecule manipulation of islet amyloid polypeptide. Chem Biol. 2014 June 19; 21(6):775-81.

Munro JB, Nath A, Farber M, Datta SA, Rein A, Rhoades E, Mothes W. A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014 Mar; 88(6):3577.85.

Nath A, Rhoades E. A flash in the pan: dissecting dynamic amyloid intermediates using fluorescence. FEBS Lett 2013 Apr 17; 587(8):1096-105.

Wendel Nelson, Ph.D., Professor

Teitelbaum AM, Scian M, Nelson WL, Rettie AE. Efficient Syntheses of Vitamin K Chain-Shortened Acid Metabolites. Synthesis (Stuttg). 2015 Apr;47(7):944-948.

Topletz AR, Tripathy S, Foti RS, Shimshoni JA, Nelson WL, Isoherranen N. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015; 87(3):430-41.

Lutz JD, VandenBrink BM, Babu KN, Nelson WL, Kunze KL, Isoherranen N. Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems. Drug Metab Dispos. 2013 Dec; 41(12):2056-65.

Topletz AR, Thatcher JE, Zelter A, Lutz JD, Tay S, Nelson WL, Isoherranen N. Comparison of the Function and Expression of CYP26A1 and CYP26B1, the two Retinoic Acid Hydroxylases. Biochem Pharmacol. 2012 Jan 1; 83:149-163.

Allan Rettie, Ph.D., Professor

Teitelbaum AM, Scian M, Nelson WL, Rettie AE. Efficient Syntheses of Vitamin K Chain-Shortened Acid Metabolites. Synthesis (Stuttg). 2015 Apr;47(7):944-948.

Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, Hanenberg H. Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution. PLoS One. 2015 Sep 10;10(9):e0137110.

McDonald MG, Au NT, Rettie AE. P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms. Drug Metab Dispos. 2015 Nov;43(11):1661-9.

Parra EJ, Botton MR, Perini JA, Krithika S, Bourgeois S, Johnson TA, Tsunoda T, Pirmohamed M, Wadelius M, Limdi NA, Cavallari LH, Burmester JK, Rettie AE, Klein TE, Johnson JA, Hutz MH, Suarez-Kurtz G. Genome-wide association study of warfarin maintenance dose in a Brazilian sample. Pharmacogenomics. 2015;16(11):1253-63.

Rheem Totah, Ph.D., Associate Professor

Roberts AG, Katayama J, Kaspera R, Ledwitch KV, Le Trong I, Stenkamp RE, Thompson JA, Totah RA. The role of cytochrome P450 BM3 phenylalanine-87 and threonine-268 in binding organic hydroperoxides. Biochim Biophys Acta. 2016 Apr;1860(4):669-77.

Johnson AL, Edson KZ, Totah RA, Rettie AE. Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer. Adv Pharmacol. 2015;74:223-62.

Kaspera R, Kirby BJ, Sahele T, Collier AC, Kharasch ED, Unadkat JD, Totah RA. Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. Biochem Pharmacol. 2014 Sep 1; 91(1)109-18.

Evangelista EA, Kaspera R, Mokadam NA, Jones JP 3rd, Totah RA. Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes. Drug Metab Dispos. 2013 Dec; 41(12):2087-94.

Libin Xu, Ph.D., Assistant Professor

Hines KM, May JC, McLean JA, Xu L. Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry. Anal Chem. 2016 Jul 19;88(14):7329-36.

Sever N, Mann RK, Xu L, Snell WJ, Hernandez-Lara CI, Porter NA, Beachy PA. Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5904-9.

Griffiths WJ, Abdel-Khalik J, Crick PJ, Ogundare M, Shackleton CH, Tuschl K, Kwok MK, Bigger BW, Morris AA, Honda A, Xu L, Porter NA, Björkhem I, Clayton PT, Wang Y. Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients. J Steroid Biochem Mol Biol. 2016 Mar 11. pii: S0960-0760(16)30064-4.

Herron J, Reese RC, Tallman KA, Narayanaswamy R, Porter NA, Xu L. Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. Toxicol Sci. 2016 Jun;151(2):261-70.