Symposium Title: "Reactive Metabolites and Toxicity"
Thursday, October 18, 2012
1:00 pm to 5:30 pm
Room Cortez AB, Anatole Hotel, Dallas, Texas
A reception with tray-passed appetizers and wine will follow in the Coronado A Room at 5:30 pm.

All participants of the North American Regional Meeting of the International Society for the Study of Xenobiotics are invited to commemorate the scientific career of the late Professor Sidney (Sid) D. Nelson. The Symposium will be a celebration of Sid’s life with presentations from his past students and collaborators.

"Reactive Metabolites and Toxicity" will take place as an adjunct to the 18th North American Regional Meeting of ISSX. It is scheduled to follow on from an ISSX symposium chaired earlier that Thursday morning, October 18, by Prof. Paul Hollenberg as part of the regular ISSX scientific program. There is no registration fee for attending the Nelson commemorative symposium, and ISSX is offering a special one-day registration rate for those interested in participating in more of the ISSX meeting.

Make a gift to the Sid Nelson Memorial Fund. Gifts to this fund will support the creation of a Sid Nelson Endowed Professorship in the Department of Medicinal Chemistry.

 
Symposium Speakers and Titles
Chairs: Allan Rettie, University of Washington (Seattle, WA) and Cyrus Khojasteh, Genentech Inc. (San Francisco, CA)

• 1:00 pm: Allan Rettie: "Welcome and Introductory Comments"
• 1:10 pm: Peter Moldeus (Karolinska Institute, Stockholm, Sweden): "Sid’s Scandinavian Sabbaticals - His Contributions to Research and Education"
• 1:50 pm: David Porubek (University of Washington, Seattle, WA): "Estrogen Biosynthesis and Catechol Estrogen Metabolites"
• 2:30 pm: Lance Pohl (NHLBI, Bethesda, MD): "Role of Reactive Metabolites and the Innate and Adaptive Immune Systems in Drug-induced Liver Injury"
• 3:10 pm: Coffee Break

Chairs: Mingshe Zhu, Bristol-Myers Squibb (Princeton, NJ), and Weichao Chen, Vertex Pharmaceuticals (San Diego, CA)

• 3:30 pm: Cyrus Khojasteh: "Pennyroyal Oil Hepatotoxicity and the Role of Reactive Metabolites of Pulegone and Menthofuran"
• 4:10 pm: Peter Rademacher (Lawrence Berkeley National Labs, Berkeley, CA): "Tienilic Acid and Its Positional Isomer: A Comparison of the Metabolism and Toxicity of an Intrinsic and an Immune-Mediated Hepatotoxin"
• 4:50 pm: Thomas Baillie (UW, Seattle, WA): "Quinones, Quinoneimines, and Xenobiotic-Protein Adducts: Potential Mediators of Drug-Induced Toxicity"
• 5:30 to 7 pm: Reception in Room Coronado A

**While there is no formal registration needed for the symposium, please RSVP by emailing  This email address is being protected from spambots. You need JavaScript enabled to view it. or calling 206-616-7613, so we can track attendee numbers and better plan for the reception event.**

Symposium Organizing Committee:
Allan Rettie
Cyrus Khojasteh
Mingshe Zhu
Weichao Chen
Tom Baillie
Claire Forster (UW)