Nina Isoherranen
Isoherranen, Nina - Associate Professor
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Research Interests:
Metabolism, disposition and biological effects of Retinoic acid; Role of P450 enzymes in fetal development;Drug diposition and drug safety during pregnancy; Pharmacokinetic modeling and molecular mechanisms of drug-drug interactions
Biography:
Dr Isoherranen received her bachelor's degree in chemistry and her master's degree in Analytical Chemistry in 1998 from the University of Helsinki, Finland. She obtained a PhD from the Hebrew University of Jerusalem in 2003 and continued her training as a post-doctoral fellow with Ken Thummel at the University of Washington. She joined the Department of Pharmaceutics as an Acting Assistant Professor on November 2004.
Research in Dr Isoherranen's lab focuses on cellular and biochemical characterization of the CYP26 enzymes and their role in retinoic acid metabolism. The research also includes evaluation of drug safety during pregnancy and the role of P450 enzymes in teratogenicity and fetal development. In addition, Dr Isoherranen's lab is conducting research on the molecular mechanisms of enzyme inhibition, the in vitro to in vivo predictions of drug interactions and the role of metabolites in drug-drug interactions.
