Professor, Department of Pharmaceutics; Director, UW Research Affiliates Program on Transporters
Postdoctoral fellowship, University of California at San Francisco; PhD, University of Manchester; BPharm, University of London
- Mechanisms of drug interactions with HIV drugs
- Impact of efflux transporters (e.g. P-glycoprotein) at the blood-brain barrier on efficacy and toxicity of central nervous system drugs
- The role of nucleoside transporters in the disposition of nucleoside drugs
- Mechanisms of changes in maternal and fetal drug disposition during pregnancy
Jashvant "Jash" Unadkat has been on faculty in the Department of Pharmaceutics since 1985. He also holds an adjunct appointment in the Department of Anesthesiology and research affiliate appointments with the UW Center for AIDS and STD Research and the Center for Human Development and Disability. He studies the transport and metabolism of HIV and other antiviral drugs. His research into drug transport could potentially lead to better ways to treat diseases such as Hepatitis C, AIDS and Alzheimer's.
Dr. Unadkat is the 2012 recipient of the American Association of Pharmaceutical Scientists (AAPS) Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism. He has previously served as associate editor for the "Journal of Pharmaceutical Sciences," editor of "AAPS Journal," and a member of the National Institutes of Health Pharmacology study section. He has published more than 150 peer-reviewed research papers and is a fellow of American Association for the Advancement of Science, AAPS, and Japanese Society for the Study of Xenobiotics.He is the founding member of the focus group of AAPS on Drug Transport and Uptake.
Unadkat created and leads the UW Research Affiliates Program on Transporters (UWRAPT), a cooperative effort between the UW School of Pharmacy and pharmaceutical companies. He also leads UWPKDAP, a NIDA funded program project grant on drug disposition during pregnancy.