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Pharmacological Sciences Summer Diversity Program

About The Program

The Pharmacological Sciences Summer Diversity Program ("PSSDP" or "the Program") provides research opportunities for talented undergraduate students from diverse social and cultural backgrounds to perform hands-on research in the basic biological and physical sciences, in the broadly defined areas of drug metabolism, pharmacokinetics, cellular pharmacology, molecular pharmacology, and biophysical virology. The Program will host three undergraduate students in the Departments of Medicinal Chemistry and Pharmaceutics, selected from a national pool of applicants as well as those enrolled at the UW. In addition to intensive research experiences, participants will benefit from graduate student, post-doctoral, and faculty mentors. Participants will also receive a generous stipend, living accommodations, and a transportation allowance for travel to and from the UW campus.

Participating Faculty

Rettie, Allan E. (Medicinal Chemistry)     Web site
Drug metabolism: Structure-function relationships and pharmacogenetics of P450.

Atkins, William M. (Medicinal Chemistry)     Web site
Structure-function mechanism of glutathione S-transferases and cytochrome P450; protein engineering of supramolecular aggregates.

Catalano, Carlos E. (Medicinal Chemistry)      Web site
Mechanistic Studies on Virus Assembly ~ Kinetic, biochemical, biophysical and structural characterization of DNA packaging motors.

Kunze, Kent L. (Medicinal Chemistry)     Web site
Cytochrome P450 catalzyed drug metabolism, enzyme kinetics and mechanisms; prediction of drug-drug interactions.

Lee, Kelly. (Medicinal Chemistry)     Web site
Biophysical studies of conformational dynamics in viruses. Influenza Hemagglutinin: Structure, Dynamics and Cooperativity During Fusion.

Totah, Rheem A. (Medicinal Chemistry)     Web site
Endogenous and exogenous functions of CYP2C8 and CYP2J2 and their role in extrahepatic toxicity.

Thummel, Kenneth E. (Pharmaceutics)     Web site
Mechanisms of inter-individual variability in CYP3A expression and catalytic activity; pharmacokinetic modeling of human intestinal and hepatic drug metabolism and drug-drug interactions.

Hu, Shiu-Lok. (Pharmaceutics)     Web site
Structure and function of Viral antigens; vaccine and therapy against primate immunodeficiency viruses (SIV, HIV-1 and HIV-2).

Isoherranen, Nina. (Pharmaceutics)     Web site
Metabolism, disposition and biological effects of Retinoic acid; Role of P450 enzymes in fetal development; Drug disposition and safety during pregnancy; Pharmacokinetic modeling and molecular mechanisms of drug-drug interactions.

Mao, Qingcheng. (Pharmaceutics)     Web site
ABC protein-mediated drug transport; structure, function and molecular mechanisms of ABC transporters; Role of ABC transporters in drug disposition during pregnancy.

Unadkat, Jashvant. (Pharmaceutics)     Web site
Mechanisms of transport and metabolism of drugs used in the treatment of AIDS and AIDs-associated opportunistic infections.

Wang, Joanne. (Pharmaceutics)     Web site
Mechanism of drug transport and disposition in the CNS; Role of membrane transporters in drug elimination in the kidney.

Bajjalieh, Sandra M. (Pharmacology)     Web site
Molecular basis of neurotransmission, the role of Synaptic Vesicle Protein 2 in modulating neurotransmitter release, and the role of lipid modifying enzymes in neuronal function.

Beavo, Joseph A. (Pharmacology)    Web site
Regulation and mechanism of action of cyclic nucleotides.

Catterall, William A. (Pharmacology)   
Molecular basis of electrical excitability; regulation of excitability of nerve and muscle cells; mechanism of actions of drugs and toxins that affect electrical excitability; structure and function of ion channels; molecular mechanisms in epilepsy.

Chavkin, Charles (Pharmacology) (Center for Drug Addiction Research)    Web site
Molecular signal transduction mechanisms mediating the addictive properties of drugs of abuse: morphine and cocaine.

Cook, David (Medicine/Gerontology and Geriatric Medicine) (Pharmacology)   
Molecular mechanisms of Alzheimer's disease.

Gardner, Richard G. (Pharmacology)    Web site
Ubiquitin-mediated regulation in the nucleus: nuclear protein quality control and its role in protecting against neurodegenerative diseases; regulation of chromatin structure in telomere silencing, gene activation, and DNA repair; global ubiquitin proteomics to identify novel ubiquitination pathways.

Hague, Christopher (Pharmacology)    Web site
G-protein coupled receptors (GPCRs).

McKnight, G. Stanley (Pharmacology) (Population Research Center)    Web site
Cyclic AMP mediated signal transduction.

Moon, Randall T. (Pharmacology) (Howard Hughes Medical Institute) (Institute for Stem Cell & Regenerative Medicine)  
Wnt signaling pathways: functions in development, disease, and regeneration; delineation of pathways by siRNA, proteomics, and small molecule modulators identified by high throughput screening.

Nathanson, Neil M. (Pharmacology)    Web site
Cell and molecular biology of neural signal transduction proteins; regulation, function, and neuroplasticity of muscarinic acetylcholine receptors, G proteins, and receptors for neuronal differentiation factors.

Phillips, Paul E.M. (Pharmacology) (Psychiatry & Behavioral Science)    Web site
Phasic dopamine release in motivated behavior, decision-making, and mental illness.

Scott, John (Pharmacology) (Howard Hughes Medical Institute)    Web site
Specificity of signal transduction events that are controlled by anchoring proteins, regulation of signal transduction in time and space.

Stella, Nephi (Pharmacology) (Psychiatry & Behavioral Science)    Web site
Cells and receptors controlling neuroinflammation.

Storm, Daniel R. (Pharmacology)    Web site
Molecular basis of neuroplasticity including mechanisms for long-term memory formation, drug resistance, and chemosensory mechanisms and the relationship between memory persistence and circadian biology.

Tempel, Bruce L. (Otolaryngology/Head Neck Surgery) (Pharmacology)    Web site
Neurogenetics of the auditory system and hearing loss in mice and humans.

Wang, Edith H. (Pharmacology)    Web site
Control of gene expression in cell proliferation, muscle differentiation and human disease.

Xia, Zhengui (Toxicology/Environmental Health)   
Mechanisms for regulation of apoptosis in animal cells, particularly in relation to neurodegneration and aging; neural stem cell regulation, differentiation and survival during during development and in adults; stem cell biology and neurodegeneration; kinase signal transduction mechanisms in the central nervous system.

Zheng, Ning (Pharmacology)    Web site
Structural biology of protein ubiquitination and protein degradation.

About Seattle

Outside of research and the lab, students have the opportunity to explore the sights of Seattle and experience the local culture. For more information, visit the UW's Seattle Life page.

Eligibility

The Program is open to U.S. citizens only. Applications are currently being accepted for the summer of 2014, which will start on June 23 and end on August 22. Students must be able to commit to these dates in order to apply and be considered for acceptance into the Program.

Application Package

Application materials are due on February 10, 2014. More information, and application instructions, can be found on the Information for Applicants page.