Goodlett's SAWN Method to be Commercially Developed
Last year, Dr. Dave Goodlett's lab developed a method to make mass spectrometry research easier - Surface Acoustic Wave Nebulization (SAWN). With help from the UW Center for Commercialization, plans are to further develop the technology and make it commercially available. See all the exciting details in this article, written by Melinda Young, on the School of Pharmacy website.
Congratulations to Team Goodlett!
Med Chem Mourns Beloved Professor and Dean Emeritus
It is with great sadness that we report the death of Professor of Medicinal Chemistry Sidney D. Nelson, who passed away unexpectedly on December 9. Dr. Nelson, who was also Dean Emeritus of the School of Pharmacy, was admired and respected by everyone fortunate enough to know him, not only at our School but throughout the University and beyond.
Click this link to read the School of Pharmacy webpage honoring Dr. Nelson's many accomplishments, as well as providing details about his memorial service. An online guestbook has also been created at http://memorialwebsites.legacy.com/rememberingsid/Homepage.aspx if you would like to share your stories and memories of Dr. Nelson.
Sid, we miss you more than words can express.
Grad Student Wins ISSX Poster Competition
Congratulations to Med Chem student Tricia (Chunsheng) Zhao, whose poster won second place in the predoctoral category at the 17th North American Regional ISSX conference in Atlanta, Georgia. Six finalists from each category were selected to present their posters during a poster viewing session at the conference, which ran from October 16-20. First, Second, and Third place awards were given at a special presentation event. Tricia is a member of Sid Nelson's lab. Good job, Tricia!
Med Chem's Kelly Lee gives Science in Medicine Lecture
Kelly Lee, Ph.D., Assistant Professor of Medicinal Chemistry, gave a lecture on campus on November 2 as part of the prestigious Science in Medicine Lecture Series. The Science in Medicine Lecture Series, now over 35 years in existence, recognizes the outstanding research of UW faculty.
Details are listed below. Congratulations, Kelly!
Kelly Lee, Ph.D.
"Capturing Snapshots of the Cell Invasion Machinery of Influenza Virus and HIV"
Wednesday, November 2, 2011
12:00 p.m. - 1:00 p.m.
D-209, Turner Auditorium, Health Sciences Building
School of Pharmacy Welcomes 2011-2012 Students
New students, L-R: Mavis Li, Theresa Aliwarga, Sam Arnold, Brian Buttrick, Jennifer Sager, Brian Chapron, and Hsiu Tzu Tung. Joe Yracheta is pictured below, in front of a painting honoring the late Dr. and Mrs. Philip Fialkow (former UW Dean of Medicine).
On September 26, Department Chairs Allan Rettie (Medicinal Chemistry) and Ken Thummel (Pharmaceutics) joined Dean Tom Baillie in welcoming eight new graduate students to the School of Pharmacy for the 2011 academic year.
Left: Dean Baillie prepares to take the podium.
Joining the school this year are: Mavis Li and Theresa Aliwarga (PhD, Medicinal Chemistry); Brian Buttrick and Joe Yracheta (Masters, Pharmaceutics); Sam Arnold, Jennifer Sager, Brian Chapron, and Hsiu Tzu Tung (PhD, Pharmaceutics).
Thanks to stirring speeches, essential "newbie" information, and yummy breakfast treats, a good time was had by all.Our warmest welcome, support, and best wishes to our new students -- and welcome to another year with us, current students!
Below: Students, faculty and staff enjoy the program and the eats.
Med Chem Staffer Celebrates 10 Years at UW
Eddie Sabiniano, our Med Chem Scientific Stores Attendant, recently celebrated his 10th year anniversary with the University of Washington. Eddie began working at UW Bothell campus and transferred to Medicinal Chemistry nine years ago. Congratulations, Eddie!
Congrats also to Lois Yamamoto, our Budget/Fiscal Analyst, celebrating one year at Med Chem, and Caryl Lynch, Program Coordinator, celebrating three years at Med Chem.
Dean Baillie Named Fellow of the American Chemical Society
The American Chemical Society (ACS) has named Dean Thomas Baillie one of its 2011 fellows. This honor goes to distinguished scientists who demonstrate outstanding accomplishments in chemistry and make important contributions to ACS, the world’s largest scientific society. Dean Baillie is one of five UW scientists who received this honor for 2011, the International Year of Chemistry. Read the ACS press release (PDF). Read UW Today article. Congratulations to Dean Baillie on being recognized for his achievements in the field of chemistry!
Congratulations, 2011 Graduates!
Congratulations to the following students, who were awarded the Doctor of Philosophy in Medicinal Chemistry during the School of Pharmacy’s June 10, 2011 commencement exercises:
Front row (L-R): Med Chem graduates Peter Rademacher, Kelsey Hanson, Tasha Ritchie, and Mariko Nakano.
Back row: Pharmaceutics graduates Brian Kirby, Jayne Thatcher, Peng Hsiao, and Jing Yang.
(Photo by Peng Hsiao)
Kelsey L. Hanson
B.S. 2005, University of Puget Sound
Dissertation: "Mechanism-Based Inactivation of Cytochrome P450 3A4: An Examination of the Sequential Metabolites of Diltiazem and the Reactive Metabolites of Trans-Resveratrol."
(Dr. Hanson is currently a Research Scientist at Proteotech, a company that focuses on the discovery and development of drugs for treating Alzheimer's and Parkinson's diseases.)
B.S. 2001, Regis University
Dissertation: "Growing Pains of Bacteriophage Lambda: Examination of Procapsid Maturation into Capsids."
Photos by Nick Au (pictured with Mariko in center photo)
B.S. 2004, University of Washington
Dissertation: "Biochemical Characterization of CYP4V2 and its Role in the Retinal Disease, Bietti Crystalline Dystrophy."
B.S. 2003, Western Washington University
Dissertation: "Tienilic Acid and Its Positional Isomer: A Comparison of the Metabolism and Toxicity of a Presumed Immune-Mediated and Intrinsic Hepatotoxin."
(Dr. Rademacher will continue his work in Medicinal Chemistry.)
Tasha K. Ritchie
B.S. 2003, Seattle University
Dissertation: "Applications of Phospholipid Bilayer Nanodiscs for the Study of Membrane Proteins and Lipoproteins."
(Dr. Ritchie will be working as a post-doctoral fellow in Dr. Kenny Linton's Membrane Transport Biology group at Queen Mary University of London in the UK.)
Btech 2001, Indian Institute of Technology, India; M.S. 2002, University of Washington
Dissertation: "Structural and Functional Characterization of Bacterial Secretion Systems Using Mass Spectrometry."
(Dr. Singh is currently a Postdoctoral Fellow in the Physical Biosciences Division at the Lawrence Berkeley National Lab.)
We are very proud of our graduates and wish them the best in their future endeavors!
Tad Davenport, a graduate student in the Department of Global Health's Pathobiology program who is currently working in Medicinal Chemistry (Lee Lab), has received an NIH T32 training grant. The "Diseases of Public Health Importance Training Grant" provides the recipient with a stipend, tutition assistance, health benefits, and travel support. The competitive application process evaluates an applicant's past academic record, proposed research, and letters of reference. Topics such as host-pathogen interactions and immune invasion are emphasized.
"I am incredibly grateful to the Pathobiology program and the Department of Global Health," said Tad, "for giving me the chance to pursue my research in Kelly Lee's lab, where I hope to work towards understanding the role of carbohydrates in modifying the conformation of the HIV-1 Envelope surface protein."
Congratulations, Tad - best wishes for success in your research!
Med Chem Student Receives NSF Fellowship
The National Science Foundation's Graduate Research Fellowship Program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering and mathematics disciplines who are pursuing research-based master's and doctoral degrees. Med Chem grad student Lucas Monkkonen (Goodlett and Catalano Labs) has recently received this prestigious award. NSF Fellows are given a stipend, cost-of-education and travel allowances, international research and professional development opportunities, and TeraGrid supercomputer access.
According to the NSF web site, "NSF Fellows are anticipated to become knowledge experts who can contribute significantly to research, teaching, and innovations in science and engineering."
"I'm excited to have won an NSF fellowship award," said Lucas. "It was a very competitive process, and I could not have done it without everyone who helped me with my application." Lucas will use the award to fund his interdisciplinary studies applying structural mass spectrometry techniques to gain insight into lambda virus proteins. "Thanks to the fellowship award, I'm even more motivated to work hard in the lab," added Lucas.
Congratulations, Lucas, on this award! We look forward to hearing more about your research in the future.
Sid Nelson Receives Volwiler Research Achievement Award
Dr. Sidney D. Nelson, Med Chem Professor and Dean Emeritus of the School of Pharmacy, will receive the prestigious Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy (AACP) this July. See the AACP's announcement and this article in UW Today to read about Dr. Nelson's many scientific accomplishments and research interests. With characteristic modesty, Dr. Nelson gives credit to his students, colleagues, and other collaborators for his successful research activities. Congratulations, Sid, on this well-deserved award!
Goodlett Lab Develops Mass Spectrometry Technique
The Goodlett Lab has developed a new mass spectrometry method which is being patented by the UW. As seen in this YouTube video, a 2-microliter droplet is nebulized by surface acoustic waves generated from a piezoelectric lithium niobate surface (provided courtesy of the Cooper Group, University of Glasgow). The droplets are drawn into the transfer capillary of a Thermo LTQ-FTICR mass spectrometer for analysis.
The UW has filed a patent on the use of surface acoustic wave nebulization (SAWN) as a means to introduce nonvolatile samples into a mass spectrometer from a flat surface at atmospheric pressure. The associated publication is Heron SR, et al., "Surface Acoustic Wave Nebulization of Peptides as Microfluidic Interface for Mass Spectrometry." Anal Chem. 82(10):3985-3989 (2010).
"The SAWN method provides a new way to introduce nonvolatile samples into a mass spectrometer without the need for capillaries or any nozzle as is needed by electrospray ionization, while maintaining the benefits of multiple charging," said Dr. Dave Goodlett. "For example, we are quite excited about the use of SAWN to accelerate our lipid structure analysis."
Congratulations to the Goodlett Lab on this exciting development!
New Scientists at Med Chem
Two Visiting Scholars and one Research Associate have recently joined the department.
Hideo Takakusa joined us in February 2010 as a Visiting Scholar working with Sid Nelson's lab. He comes to us from the Drug Metabolism and Pharmacokinetics Research Laboratories at Daiichi Sankyo Co. Ltd. in Tokyo, Japan, where he did research on the metabolism of drug candidates. During his 18-month stay at UW, he will study mechanistic investigation for drug toxicity caused by reactive metabolites. When not hard at work, Hideo enjoys American sports, traveling (memorable moment: watching bears catch salmon at Alaska's Katmai National Park), and training for his first full marathon. You might spot him running around Lake Union. "I like the UW and Seattle," Hideo said. "The people are kind and friendly; nature is beautiful and magnificent; and the beer and wine are tasty."
Sung Hwan Yoon is working as a Research Associate in Dave Goodlett's lab. He received his Ph.D. in Chemistry from the University of Arizona in 2010, where he studied fundamental ion dissociation using Mass Spectrometry. At UW he wants to expand his knowledge to applied science. "Dr. Goodlett is well known for his contributions to bio-applied mass spectrometry," said Sung Hwan. His current project is structural analysis of Lipid A, which is difficult to analyze with conventional mass spectrometry techniques. The Goodlett group has developed a new ionization method and a structural analysis algorithm for Lipid A. Sung Hwan hopes to develop these methods further and build a library based on tandem mass spectrometry. Sung Hwan and his family are enjoying Seattle, especially the changing fall colors. "My boy is happy to run on grass and step on fallen leaves," he said. Exploring local coffee shops is another favorite activity. Says Sung Hwan, "You are all more than welcome to share your favorite coffee places."
Christophe Masselon is a Visiting Scholar from the Institute of Life Sciences Research and Technologies (EDyP lab– "Exploring the Dynamics of Proteomics"), CEA (French Atomic Energy Commission) in Grenoble, France. He is here on a 1–year appointment funded jointly by the European Commission/CEA project "Eurotalents," which seeks to facilitate international mobility of scientists in five research areas, including life sciences and biotechnology. Christophe is working with Dave Goodlett's lab on a project called "Optimization of Surface Acoustic Wave Nebulisation for Biological Mass Spectrometry." He was drawn to the UW because Seattle is "one of the worldwide hottest spots for proteome research." Moreover, said Christophe, "the Goodlett lab is making very original contributions to methods developments in proteomics." Christophe likes "the friendly staff at UW, and the sunny weather in Seattle." Of course, he said that before experiencing last week's downpour!
We are glad to have these talented scientists working with us. Welcome to Med Chem, gentlemen!
Med Chem Welcomes New Grad Students
The department is pleased to welcome six new grad students this year. Talk about a population explosion!
Photo, Left (front row, l-r): Wynton McClary, Amanda Johnson, Shannon Kruse. (back row): Ryan Seguin, Christopher Hincke.
Photo, Right: Long Gui.
Long Gui received his B.S. in Biological Science from the University of Science and Technology of China in 2009. He was also a Research Assistant at USTC's Lab of Structural Biochemistry, Hefei National Lab for Physical Sciences, concentrating on the structure and function of proteins sensing and transducing the signal of oxidative stress. Here at UW, his main interest is in protein structure and function. He is also a graduate student of Biomolecular Structure and Design Interdisciplinary Program.
Christopher Hincke comes to us from the University of San Diego, where he received his B.A. in Chemistry in 2010. For him, the UW Med Chem program stood out from other schools during the interview process. "I am eager to learn the pharmacology and biochem techniques that will prepare me for a career in drug discovery," said Chris. "Collaboration is another strong aspect of the department, and I look forward to working with many talented scientists." In his free time, Chris enjoys playing guitar and painting.
Amanda Johnson received her B.S. in Biological Chemistry from the University of Chicago in 2005. She has since been working as a Research Associate at Cerep, Inc. "I chose Medicinal Chemistry's graduate program because of its research in drug metabolism," said Amanda, "which promises interesting work and research possibilities." When not hard at work, Amanda enjoys hiking and backpacking in the Cascades.
Shannon Kruse comes to us from Montana State University, where she received a B.S. in Biochemistry in 2009. She worked with viruses at MSU and is interested in doing the same here at UW. Shannon enjoys the great outdoors, especially dirtbiking and snowboarding.
Wynton McClary received his B.S. in Biology from Eastern Washington University in 2010. "I spent the summer of 2009 with UW Med Chem as an Amgen Scholar and fell in love with the environment here and the research," said Wynton. His hobbies include playing jazz guitar and tennis. "Also, I love Asian food!"
Ryan Seguin received his B.S. in Chemistry from the UW in 2010. "I chose Medicinal Chemistry at the UW because of a highly collaborative environment and the opportunity to learn a multitude of bioanalytical techniques," said Ryan. "What I love about researching drug interactions is the potential for work done in a laboratory to ultimately translate into improvements in health care."
Welcome to the Med Chem family! We are glad to have you with us.
Remembering Nate Hall
Congratulations, 2010 Graduates!
Congratulations to the following students, who were awarded the Doctor of Philosophy in Medicinal Chemistry during the School of Pharmacy’s June 11, 2010 commencement exercises:
Shawna Mae Hengel
B.S. 2002, Santa Clara University
Dissertation: "Mass Spectrometry in Proteomics: From Data-Independent Proteomic Profiling to Targeted Post-Translational Modification Characterization."
(Dr. Hengel is now a Postdoctoral Research Associate at the Pacific Northwest National Laboratory in Richland, WA.)
Laura M. Shireman
B.A. 1997, Washington State University; B.S. 2002, WSU
Dissertation: "Interactions of Glutathione Transferases with 4-Hydroxynonenal and Glutathione."
(Dr. Shireman will be working as a Postdoctoral Research Associate for Dr. Yvonne Lin in Pharmaceutics at UW.)
B.S. 2002, Santa Clara University
Dissertation: "Acetyl-p-aminophenol and Acetyl-m-aminophenol: Using Structure-Toxicity Relationships to Characterize Hepatocellular Injury."
(Dr. Stamper is working as a Postdoc Research Fellow for Dr. Michael Cunningham in the Center for Tissue and Cell Sciences at Children's Hospital.)
Brooke Marie Gartland VandenBrink
B.S. 2003, Grand Valley State University
Dissertation: "The Role of Metabolites in Mechanism-Based Inactivation of Cytochrome P450 Enzymes."
(Dr. VandenBrink is working as a scientist at Amgen.)
We are very proud of our graduates and wish them the best in their future endeavors!
Dr. Nathan A. Hall, former professor of Pharmacy, died June 2 at Evergreen Hospice after suffering a stroke. He was 92. Nate Hall entered UW at the age of 16 and graduated Summa Cum Laude at age 19. After marrying the late Beatrice Hartnett in 1938, he served in the U.S. Army during World War II. He earned his Ph.D. in Pharmacy at the UW, married Florence Turnbull in 1960, and was a Professor of Pharmacy here until his retirement in 1981.
"Dr. Hall was my undergraduate mentor; he had a major influence on my career and research," said Dr. Bill Hayton, UW Class of 1967 and now Associate Dean of the College of Pharmacy at Ohio State University. "I was a participant in the NSF-sponsored Undergraduate Research Program and was in his lab at Bagley Hall from 1965-67. We conducted drug absorption studies using a fish model. One of our published papers based on this work won a Lunsford Richardson Pharmacy Award. The cash was applied to purchase a 1966 Buick!" said Dr. Hayton. He added, "Dr. Hall was instrumental in getting me to go to graduate school. I was very lucky to have known him and to have received his guidance."
In 1959, Dr. Hall was awarded a Fulbright Senior Lectorship to the University of Malay in Singapore. In 1968 he took a sabbatical to serve as Visiting Professor of Pharmacy at the University of Sydney in Australia. He and his wife enjoyed traveling. According to Dr. Wendel Nelson, who knew him before and during his long retirement, Dr. Hall was "very competitive, and very good" at sports, including bowling, handball, and golf, "which he played right into his 90s."
Dr. Hall is survived by his children, Dennis and Pamella, seven grandchildren, and his brother, Gregory. He will be missed by his many friends and admirers in the School of Pharmacy, and long remembered for his contributions to science at the UW.
Dean Baillie Awarded RSC Fellowship
Thomas Baillie, former Med Chem professor and now Dean of the School of Pharmacy, has been elected a Fellow of the Royal Society of Chemistry. The RSC is the largest organization in Europe for advancing the chemical sciences. It began as the Chemical Society of London in 1841, and now has 46,000 members worldwide. RSC activities span education, conferences, science policy, and the promotion of chemistry to the public. Chemistry World and the brand-new Chemical Science journals are among its many publications. The coat of arms you see here displays the motto Pro scientia et humanitate -- "for the sake of knowledge and for the benefit of mankind."
The prestigious fellowship designation awarded to Dean Baillie recognizes a high standard of professional competence and honors him for his significant contributions to the advancement of chemical sciences and the chemical profession.
Congratulations to Dean Baillie!
Med Chem Student Receives Magnuson Scholarship
Med Chem graduate student John Chapman has been awarded the prestigious Magnuson Scholarship for 2010. The University names six Magnuson Scholars each year, one from each of the health sciences schools: Pharmacy; Public Health and Community Medicine; Dentistry; Nursing; Social Work; and Medicine. Magnuson Scholars are selected on the basis of their academic performance and potential contributions to research in the health sciences. The late Senator Warren G. Magnuson, in whose name the program was established, was committed to improving health through biomedical research.
As a Magnuson Scholar, John will focus part of his research on Type 1 Diabetes (T1D). He will use mass spectrometry (MS) to examine the proteome of a sample set from the Type 1 Diabetes Prediction and Prevention Project (DIPP) provided by our collaborators in Turku, Finland. The goal of this pilot project is to identify biomarkers predictive of T1D onset. Early detection of T1D is extremely important in patient awareness, controlling disease progression, and decreasing prevalent T1D health complications.
"It is an honor to join the group of students that have received the Magnuson award," said John. "It will provide me with an amazing opportunity to work on extremely valuable samples from the Finnish DIPP study and focus my time on clinically relevant research."
John is a member of Med Chem's Goodlett Lab, which recently developed a novel data-indpendent tandem mass spectrometry method known as Precursor Acquisition Independent From Ion Count (PAcIFIC). the PAcIFIC method extends detectable proteome dynamic range by an order of magnitude without any sample pre-fractionation. John will use a multiplexed, quantitative version of PAcIFIC (qPAcIFIC) to determine the relative abundance of serum proteins over the longitudinal blood samples of patients prior to and after development of T1D.
Working under the supervision of Med Chem Professor Dr. Dave Goodlett and Dr. Nina Isoherranen, Assistant Professor of Pharmaceutics, John is also using the qPAcIFIC method to identify retinoic acid-specific proteomic changes in human tissues and cell lines treated. One of the aims of this project is to identify proteomic changes that could explain how retinoids improve insulin sensitivity and regulate sugar and fat metabolism during development of T1D.
"John, Nina and I are excited about the opportunity to work on Type 1 Diabetes with such precious samples as these from the Finnish DIPP study. The scholarship funds will allow us to conduct a preliminary study of our novel qPAcIFIC method," said Dr. Goodlett.
Read more about the Magnuson Scholarship and John Chapman in the recent UWeek article.
Congratulations on this well-deserved honor, John!
Med Chem Remembers Walter McCarthy
Walter C. McCarthy, former professor of medicinal chemistry at UW, died March 1, 2010 in Bremerton, at the age of 87. Dr. McCarthy earned a degree in chemistry from MIT in 1943 and served as an Army officer during WW II, researching chemical warfare. In 1949, he completed his Ph.D. in organic chemistry at Indiana University, working with Ernest Campaign, a heterocyclic chemist. He and his wife, Mary, moved to Seattle, where he began his 34-year career in medicinal chemistry at the University of Washington.
Dr. McCarthy's research interests at UW continued in heterocyclic chemistry, especially thiophenes and furans, and substituted derivatives. His students worked also on sulfur-containing radioprotective agents and on the synthesis of derivatives of aminothiophenes and aminofurans. "The odors wafting from the third floor of Bagley Hall were constant reminders of Walter's research," said Dr. Wendel Nelson, professor of medicinal chemistry. Dr. Kent Kunze, associate professor of medicinal chemistry, concurs. "He just loved sulfur research," said Kent, who was a student in some of Dr. McCarthy's classes. Like Kent, Dr. McCarthy's students went on to successful careers in teaching, the drug industry, and analytical laboratory research.
Dr. McCarthy retired from the UW in 1982. Along with his second wife, Virginia, he enjoyed traveling, swimming, and exercising his mind with crossword and Sudoku puzzles. He is survived by his wife, Virginia; four children from his blended family; and three grandchildren.
Med Chem and Pharmaceutics Announce New Summer Program
The Pharmacological Sciences Summer Diversity Program is a new program being offered this summer by the Departments of Medicinal Chemistry and Pharmaceutics. The program will provide research opportunities for two undergraduate students to perform hands-on research in the basic biological and physical sciences, in the broadly defined areas of drug metabolism, pharmacokinetics, cellular pharmacology, molecular pharmacology, and biophysical virology. For details about the program and application requirements, see the program's home and information pages.
Med Chem Asst. Professor Makes Cover of Drug Metabolism
Drug Metabolism Cover Congratulations to Dr. Rheem Totah, Assistant Professor of Medicinal Chemistry, whose illustration for the article "Identification of Novel Substrates for Human Cytochrome P450 2J2" graces the cover of the February 2010 issue of Drug Metabolism and Disposition. Dr. Totah wrote the article in collaboration with Pfizer Global Research and Development. Click on the image to see a larger version. Find the PubMed link to the article here.
In Memoriam: William F. Trager (October 17, 1937 - November 24, 2009)
It is with great sadness that we learned that Dr. William Trager lost his brief battle with pancreatic cancer on November 24, 2009 at the age of 72. Bill was born on October 17, 1937 in Winnipeg, Canada and became a naturalized U.S. citizen. He received his B.S. in chemistry from the University of San Francisco in 1960, and his Ph.D. in medicinal chemistry from the University of Washington, Seattle, in 1965. His thesis research, under the supervision of Professor Alain C. Huitric, focused on the application of nuclear magnetic resonance to conformational analysis of drugs that contained cyclohexyl ring structures. Bill went on to do his postdoctoral research from 1965-1967 at the Chelsea School of Science and Technology in London, investigating alkaloid structures under the supervision of Sir Arnold Beckett.
In 1967, he joined the faculty of the University of California-San Francisco School of Pharmacy as an assistant professor of medicinal chemistry. While at UCSF, he acted as director of the high-resolution mass spectrometry center. Bill was one of the first to apply stable isotope labeling and mass spectrometry (particularly the then new technique of chemical ionization mass spectrometry) to studies of drug metabolism. Drug metabolism became the focus of his life’s research.
In 1972, Bill was recruited back to the UW School of Pharmacy to be a professor of medicinal chemistry where he served as chair of the Department of Medicinal Chemistry from 1980-1983. He also was appointed as an adjunct professor of the UW Department of Chemistry.
During his career, Bill Trager was an outstanding, encouraging mentor to 22 graduate students and 12 postdoctoral fellows. Most of his trainees are active researchers in academia, government research laboratories, and in the pharmaceutical industry. Several have won awards for their work, including three who have received scientific achievement awards, one from ISSX, one from ASPET, and one from SOT. Bill was well known by his students as an insightful scientist who excelled at encouraging others to do their best.
Over his career, Bill published ~200 research papers and co-authored books on drug interactions and on the chemical and enzymatic aspects of drug metabolism. He was internationally renowned for his work on warfarin metabolism and mechanisms of warfarin drug interactions, and one of his major achievements was to characterize some of the mutations of CYP2C9 involved in dysfunctional warfarin metabolism that could put people at risk of bleeding. Bill also was a pioneer in the use of pseudoracemates to identify and kinetically characterize isomers of drugs and their metabolites. Furthermore, he was instrumental in clarifying the theoretical basis for deuterium isotope effects in catalytic mechanisms of cytochrome P450 oxidation reactions. Bill was the principal investigator for nearly 20 years of a National Institutes of Health Program Project Grant investigating mechanisms of drug interactions. He received the Alumnus of the Year Award from the UW School of Pharmacy in 2001, and remained with the UW until his retirement in 2004.
Throughout his career, Bill was active in the International Society for the Study of Xenobiotics (ISSX), as an original charter member and Council member from 1986-89. He was invited to present at several ISSX and other meetings throughout the world, and organized the 4th International ISSX meeting held in Seattle, Washington, in 1995. He also attended several Drug Metabolism Gordon Conferences, contributing as a discussion leader and presenter to numerous conference symposia. Bill’s interests extended to chiral drug interactions, and he served as the editor of the journal Chirality for several years through the 90s, and also as a member of the Editorial Board of Drug Metabolism and Disposition from 1994-2002.
Bill’s scientific prowess opened the door for many scholarly appointments. He became science advisor to the Seattle district of the FDA, was a member of the Pharmacological Sciences Review Committee of the National Institutes of General Medical Sciences of the NIH, and served ad hoc on several NIH center and program project grants, as well as other grant committees.
Away from work, Bill enjoyed playing squash, golf and a little poker from time to time. On the squash court, he was an immovable force controlling the game from the center of the floor. On the golf course, control was rarely in Bill’s hands, but he loved the game nonetheless!
Bill was loved by his family, friends, colleagues and students. He was a man who was known for his sense of humor, collegial nature and keen intellect, but it is difficult to measure the full impact he had on all who benefited from his wonderfully warm smile and kind demeanor. We will always remember how genuinely welcomed he made people feel and how he always spoke of his family with pride and love.
The UW School of Pharmacy and the wider research community have lost a brilliant mind and a compassionate, kind soul. Bill will be sorely missed by all those who had the privilege of knowing him.
He is survived by his loving wife of 25 years, Caryl, and seven children from his blended family, as well as several grandchildren and one great-granddaughter.
Med Chem Researchers Receive ARRA Funding
Contgratulations to Med Chem Professors Allan Rettie and Dave Goodlett -- they have received funding for two of their research projects via the American Recovery and Reinvestment Act (ARRA) from the National Institutes of Health (NIH).
Dr. Rettie's grant of $295,642 will enable him to research the mechanistic basis for adverse drug reactions to warfarin. He is the Principal Investigator for the project, "Pharmacogenetics of ADRs: Warfarin Toxicity."
Dr. Goodlett was awarded a $317,997 subcontract on the project "Parallel Peptide Tandem Mass Spectrometry," which proposes to optimize a protein discovery method called Peptide Acquisition Independent From Ion Count (PAcIFIC). The researchers hope this method may be immediately adopted by laboratories searching for protein markers of disease.
Med Chem Welcomes New (2009) Grad Students.
The department is pleased to welcome Lucas Monkkonen and Natalie Garcia to our talented and dedicated group of graduate students this year.
Lucas Monkkonen comes to us from Grinnel College in Iowa. He was attracted to the UW because of the "fantastic research, great collegial atmosphere, and interesting mix of biochemistry, bioanalysis, and organic chemistry." He is especially interested in using instrumentation to increase his knowledge of protein biochemistry.
When Lucas is not studying, he's climbing mountains or playing piano and cello (but not at the same time). On the rare lazy morning, he indulges his taste for "unreasonable amounts" of bacon.
Natalie Garcia was an undergraduate student in the Molecular, Cell and Developmental Biology Department at UC Santa Cruz. She chose UW to "be surrounded by great people passionate about good science" who could inspire her to achieve her Ph.D. She is interested in protein chemistry (kinetic or structural) but is also open to intriguing possibilities in other directions.
Natalie enjoys playing piano, is a "huge movie buff," bikes the Burke-Gilman Trail, and swings a tennis racquet around "if the weather permits." (Hmmm. Someone forgot to tell her about our rainy winters....)
Welcome to Med Chem, Lucas and Natalie!
Dr. Alain Huitric Remembered.
Alain Huitric, professor emeritus of medicinal chemistry, passed away in late July at his home in Brittany, France, shortly before his 97th birthday. Read this tribute by former medicinal chemistry chair Bill Trager.
Med Chem Grad Student Publishes Book.
Graduate student Michelle Wahlin has written a book about the history of Sigma Delta Epsilon-Graduate Women in Science (GWIS). GWIS was incorporated in 1922; Michelle's book, 87th Year History, chronicles its colorful story.
Michelle was recruited to write the book by the GWIS via the University of San Diego's Department of Chemistry Chair, Dr. Tammy Dwyer. The 175-page book took a year to write; publication followed two years later.
"Writing this book was an amazing and unforgettable experience," said Michelle. "It gave me a unique appreciation for my opportunities as a woman in science, and for the pioneers that made these opportunities possible."
Congratulations, Med Chem Graduates.(June, 2009)
Congratulations to the following students, who were awarded the Doctor of Philosophy in Medicinal Chemistry during the School of Pharmacy's June 12, 2009 commencement exercises:
Larissa M. Balogh
B.S. 2003, California State University, Long Beach.
Dissertation: "Stereochemical Complexities in the Glutathione S-Transferase Catalyzed Detoxification of 4-Hydroxynonenal."
(Dr. Balogh is now working for Pfizer in St. Louis, Missouri.)
Kevin J. Coe
B.S. 2000, Seattle University.
Dissertation: "Metabolism and Cytotoxicity of the Nitroaromatic Drug Flutamide and its Cyano Analog in Hepatocyte Cell Lines."
(Dr. Coe is currently a scientist at Johnson & Johnson in San Diego.)
B.A. 2003, University of Virginia.
Dissertation: "Thermodynamics and Kinetics of Ligand Binding to Cytochrome P450 3A4 in Membrane Nanodiscs."
(Dr. Nath has taken a postdoctoral position in the Department of Molecular Biophysics and Biochemistry at Yale University.)
We are proud of our graduates and wish them the very best in their future endeavors!
Med Chem Staffer Attends Citizens' Academy.(June 2009)
"I like to call it 'Police Academy' but of course it's not," says Caryl Lynch, Med Chem staffer who recently completed the Spring 2009 session of the UW Police Department Citizens' Academy. Caryl is pictured here with Chief of Police John Vinson. The ten-week program, held annually on campus, allows UW students, staff, and faculty to learn first-hand about law enforcement at the University of Washington.
During the weekly sessions, officers and department personnel talked about their work. Subjects ranged from criminal procedure, weapons, and life on patrol to dispatching, evidence collection, and campus safety.
"It was a great introduction to all the ways in which the UWPD serves the University community, said Caryl, who is a Secretary Senior in Med Chem. "The discussions were fascinating. No question or concern was off-limits and the instructors were very open with us."
What was Caryl's favorite session? "I enjoyed meeting Chief Vinson and the officers," she said, "but my fave had to be Kali the K9 bomb dog and her specially modified police car!"
Med Chem Welcomes Jie Xing.(April 2009)
Dr. Jie Xing, our newest visiting scholar, joins Medicinal Chemistry via a 1-year award from the China Scholarship Council to pursue research in America. Jie Xing ("Jessie") is currently an associate professor in the School of Pharmacy at Shandong University, Jinan, China. She received her Ph.D. in Drug Metabolism and Pharmacokinetics from Shenyang Pharmaceutical University, China. Her work at Shandong University primarily involves drug metabolism and pharmacokinetics based on mass spectrometry. She is interested in expanding her research in proteomics, including quantitative description of protein expression and its changes under the influence of biological perturbations such as disease or drug treatments.
During her time at the UW, Jessie will work in Dr. Dave Goodlett's lab, researching protein structure analysis, specifically chemical cross-linking and mass spectrometry of multi-protein complexes followed by informatics analysis.
"I appreciate this opportunity to study and work with the outstanding scientists at the UW," said Jessie. "I believe everything here, including the people, the research atmosphere, and the beautiful campus, will make a deep impression on me. The knowledge and experience I gain will also benefit my future work."
"It is always a pleasure to welcome international scholars to our laboratory and to Medicinal Chemistry," said Dr. Goodlett. "Jessie will initially learn about our protein cross-linking approach and we hope she will help us to better understand metabolism and pharmacokinetics of artemisinin. As a bonus, she brings her experience on the LTQ-Orbitrap, which is a much used instrument for structure studies. We look forward to a fruitful year of study!" Welcome to Med Chem, Jessie!
Med Chem Welcomes Kelly Lee.(April 2009)
Medicinal Chemistry welcomes Dr. Kelly Lee to the faculty. Dr. Lee comes to us from The Scripps Research Institute in San Diego, where he performed postdoctoral work at the Department of Molecular Biology.
Dr. Lee was awarded an A.B. degree in Physics from Harvard University, and a Ph.D. in Biophysics from Johns Hopkins University. Kelly’s postdoctoral work at Scripps involved biophysical studies of conformational dynamics in viruses. This is a continuing research interest for Kelly, who is conducting studies on several viruses including influenza, hepatitis B, and dsDNA bacteriophages.
Dr. Lee recently received a NIH Pathways to Independence Award from NIGMS for the study of: ‘Influenza hemagglutinin: structure, dynamics, and cooperativity during fusion.' He will continue this work at the UW. “I am excited to be joining this vibrant research and teaching community,” said Kelly. “The people are awesome, and I am eager to explore the possibilities for collaboration with other groups, to learn new things, discover how viruses tick, and find out how we can target them to shut down infections. I am also very interested in the adaptation or re-engineering of viral machines as protein therapeutic delivery devices. The broad research expertise in the School of Pharmacy makes this a great place to take this work forward.”
"Kelly brings a new dimension to research in the department, and we are very pleased to have been able to attract him to our School of Pharmacy," said Dr. Allan Rettie, Med Chem department Chair. Welcome to Med Chem, Kelly!
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Remembering Tom Kalhorn.(March 2009)
The School of Pharmacy mourns the loss of Tom Kalhorn, research scientist in the Department of Medicinal Chemistry's Mass Spectrometry Center. Tom died unexpectedly on March 2, two days after suffering an epileptic seizure.
Tom Kalhorn was born in Independence, Missouri -- a fitting hometown name for Tom if there ever was one. He received his BA in Chemistry and Political Science from Grinnell College in Iowa, and did some graduate work in Chemistry at the University of Kansas.
Tom's career with the UW began in 1983. He worked in Pharmaceutics as a research technician and lecturer until 2003, when he accepted the position of research scientist with Med Chem in the Mass Spectrometry Center. Some of Tom's important contributions to Pharmaceutics and Med Chem pertained to the Drug Interaction program project grant, where he prepared critical metabolite standards for drugs of interest. He introduced a stand-alone course on quantitative analysis methodologies and was a frequent contributor to departmental cumulative exams. He was known throughout and beyond the department for his analytical expertise and intelligence. His colleagues considered him a conscientious and capable teacher who gave selflessly of his time and expertise to benefit graduate students and post-doctoral fellows.
In addition, Tom Kalhorn had a unique personal style that made him beloved as well as respected. Who will forget his dazzling and varied collection of t-shirts: tie-dyed, brightly colored, or sporting pithy statements -- usually worn with shorts whatever the time of year? Tom touched a lot of people in Med Chem, Pharmaceutics, and beyond. He will be greatly missed.
Med Chem Administrator Honored with MLK Award.(January 2009)
Med Chem department administrator Jeanine Kanov, whose volunteer work with MEOW Cat Rescue was featured in a 2008 UWeek article, has received a Martin Luther King, Jr. Community Service Award. Jeanine and other award recipients were honored at a January 15 Health Sciences event, "A Dream Realized: Forward Together with Hope."
Jeanine has volunteered for organizations such as MEOW Cat Rescue, the YWCA, and Northwest Harvest, and served as UW Combined Fund Drive Coordinator for the School of Pharmacy. Her volunteer role typically encompasses a wide range of activities -- organizing fundraising events and food drives, serving as a feline foster parent, and promoting volunteerism in general.
"Jeanine is an outstanding role model to all who know her," said Nancy Murphy, Associate Dean of Academic and Student Programs in the School of Pharmacy. "She motivates us to connect with causes that touch the heart."
“Jeanine inspires us to help make the world a better place. We in Med Chem are very pleased to see her volunteer work acknowledged,” said Med Chem Chair, Dr. Allan Rettie. Congratulations, Jeanine!
Dale Whittington Joins Mass Spectrometry Center.(January 2009)
To become the new Manager and Technical Director of the Mass Spectrometry Center, Dale Whittington only moved a few hundred feet – from the Department of Pharmaceutics. Before coming to the Center, Dale managed Dr. Jashvant Unadkat’s laboratory, handling everything from budgeting to grant proposals to equipment maintenance. Prior to that, Dale worked five years in the Department of Anesthesiology as an Analytical Chemist, where his focus was method development, sample throughput for clinical studies, and equipment maintenance.
In his new position, Dale will provide support, analytical expertise, and hands-on training to enable investigators and students to excel in their research and studies.
“It is important for the facility to continue supporting the excellent research and education provided by the School of Pharmacy and the University as well,” said Dale. “The reputation and dedication of the Mass Spectrometry Center to research and teaching does and should continue to be our focus.”
When Dale can tear himself away from science, he enjoys skiing, snowboarding, hiking and kayaking. Welcome to Mass Spec, Dale!
Med Chem welcomes Fulbright Scholar Ivanka Karadzic.(December 2008)
Joining Dr. Dave Goodlett's lab as a visiting scholar, Dr. Ivanka Karadzic comes to us from the University of Belgrade, Serbia, where she received her Ph.D. in chemistry. Ivanka is a professor in the University’s Department of Chemistry, School of Medicine, teaching general chemistry as well as basic and industrial enzymology.
Ivanka did postdoc work in Osaka, Japan through the Japanese Society for the Promotion of Science’s Invitation Fellowship Program. She has also received awards from the Serbian Chemical Society and, of course, the Fulbright Scholarship Program award that brings her to the UW. Ivanka is one of only two Serbians to receive the Fulbright for natural sciences this year. During her stay at UW, Ivanka’s research will focus on the newest wet and dry lab methods in proteomics technology. Specifically, she will work to develop novel methods for characterization of protein cross-linking via novel chemical, mass spectrometrometric and computational methods.
“I was attracted to Dr. Goodlett’s research philosophy and the unique work being done at the University of Washington,” she said. “The knowledge and experience I collect here could result in a new proteomics curriculum at the University of Belgrade.”
“Science-based cultural exchange is one of the underlying themes for our lab. Ivanka’s interest in protein structure and our development of novel methods to characterize protein-protein interactions all came together to provide her with training that she can take back to Belgrade, thanks to the Fulbright award,” said Dr. Goodlett.
Ivanka is a published author of academic and other books, including the story of her experiences in Japan and a collection of fairy tales for her nephew, Mihajlo. She practices tai chi and enjoys haiku poetry. Welcome to Med Chem, Ivanka!
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Researchers Win NIH Grant.(December 2008)
Researchers in the Departments of Medicinal Chemistry, Pharmaceutics and Pharmacy-- Drs. Allan Rettie, Ann Wittkowsky, Kent Kunze, Nina Isoherranen, Wendel Nelson, Bill Atkins, Sid Nelson and Ken Thummel-- have been awarded a total of $5 million in direct costs from the National Institute of General Medical Sciences at NIH to continue their study of fundamental mechanisms of drug-drug interactions. This PO1 grant will provide support through 2013 for three projects that that will evaluate: 1) genetic contributions to drug interactions involving warfarin; 2) metabolite-dependent drug interactions involving itraconazole, fluoxetine and diltiazem; and 3) allosterism in drug interactions involving CYP3A4.
School of Pharmacy Researchers Attend Xenobiotics Conference(October 2008)
School of Pharmacy researchers were strongly represented at the recent North American Meeting of the International Society for the Study of Xenobiotics held in San Diego Oct 12-16, 2008.
|Left Photo: Sid Nelson with New Investigator Awardee Wen Xie and ISSX President Russell Prough
Middle Photo: Postdoctoral Category winners Matt McDonald, Sook Wah Yee, and Pauline Ryan
Right Photo: Kelsey Hanson, Jon Katayama, and Brooke Vandenbrink at the welcome reception
Allan Rettie chaired the Meeting Organizing Committee, which also included Ken Thummel. Symposia chairs and speakers from the SOP included Dean Tom Baillie, Sid Nelson, Jash Unadkat and Mary Hebert. Graduate students and post-doctoral fellows from the School presented posters on a wide variety of research topics. Congratulations to Dr. Matt McDonald from Medicinal Chemistry who won third prize in the post-doctoral category for his poster titled "CYP4F2 is a Vitamin K1 Oxidase: A Molecular Explanation for Altered Warfarin Dose in Carriers of the Functionally Defective V433M Variant." Finally, an evening reception hosted by Dean Baillie at the meeting attracted a large number of SOP alumni.
UW Showcases Volunteer Efforts of Med Chem Administrator(October 2008)
As part of the UW's Combined Fund Drive campaign, University Week spotlights Jeanine Kanov, administrator of the Department of Medicinal Chemistry, for her volunteer work. See U Week Article.
Dr. Rheem Totah Presents at Drug Metabolism Conference(July 2008)
Dr. Rheem Totah presented her work on arachidonic acid metabolism by CYP2J2 and cardiotoxicity at the Drug Metabolism Gordon Research Conference held July 6-11, 2008 at Holderness School in Holderness, NH.
Dr. Sid Nelson Receives Teaching Award
Congratulations to Dr. Sid Nelson, Dean Emeritus (School of Pharmacy) on receiving the Gibaldi Excellence in Teaching Award for 2008.
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