Medicinal Chemistry - Latest Publications
Nelson WL. "Chapter 32. Antihistamines and Related Antiallergic and Antiulcer Agents." Foye's Principles of Medicinal Chemistry, 7th Edition. Williams DA and Lemke TL, Eds; pp. 1045-1072 (2012).
Topletz AR, Thatcher JE, Zelter A, Lutz JD, Tay S, Nelson WL, and Isoherranen N. "Comparison of the Function and Expression of CYP26A1 and CYP26B1, the Two Retinoic Acid Hydroxylases." Biochem Pharmacol., 83:149-163 (2012).
Peng CC, Shi W, Lutz JD, Kunze KL, Liu JO, Nelson WL, and Isoherranen N. "Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals." Drug Metab Dispos., 40:426-435 (2012).
Chang JR, Andrews BT, and Catalano CE. "Energy Independent Helicase Activity of a Viral Genome Packaging." Biochemistry, 51:391-400 (2012).
Medina E, Nakatani E, Kruse S, and Catalano CE. "Thermodynamic Characterization of Viral Procapsid Expansion into a Functional Capsid Shell." J Mol Biol., 418:167-180 (2012).
Nurmemmedov E, Castelnovo M, Medina E, Catalano CE, and Evilevitch A. "Challenging Packaging Limits and Infectivity of Phage Lambda." J Mol Biol., 415:263-273 (2012).
Park HC, Park JS, Choi JD, Dabrowski M, Atkins WM, Yoon MY. "Kinetic mechanism of fuculose-1-phosphate aldolase from the hyperthermophilic archaeon Methanococcus jannaschii." Enzyme Microb Technol., 50(4-5):209-14 (2012).
Acchione M, Kwon H, Jochheim CM, Atkins WM. "Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates." MAbs 4(3); epub ahead of print (2012).
Baillie TA and Rettie AE. "Role of Biotransformation in Drug-Induced Toxicity: Influence of Inter- and Intra-species Differences in Drug Metabolism." Drug Metabolism and Pharmacokinetics, 26:15-29 (2011).
Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy, and Rettie AE. "Finding Homes for Orphan Cytochrome P450s: CYP4V2 and CYP4F22 in Disease States." Molecular Interventions, 11:124-132 (2011).
Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Moloney C, Aldred SF, Trinklein ND, Schuetz E, Nickerson DA, Thummel KE, Rieder MJ, Rettie AE, Ratain MJ, Cox NJ, and Brown CD. "Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue." PloS Genetics, 7:(5) e1002078
(2011).
Parkinson OT, Kelly EJ, Wittington D, and Rettie AE. "Bioactivation of 4-Ipomeanol by a CYP4 Enzyme from Cow Lung and Inhibition by HET0016." J Vet Pharmacol. Ther., 2011 Sep 15 doi: 10.1111/j.1365-2885.2011.01339.x.
Thatcher JE, Buttrick B, Shaffer SA, Shimshoni JA, Goodlett DR, Nelson WL, and Isoherranen N. "Substrate Specificity and Ligand Interactions of CYP26A1, the Human Liver Retinoic Acid Hydroxylase." Mol Pharmacol., 80:228-239 (2011).
Babu KN, Kunze KL, and Nelson WL. "Metabolism of Diltiazem. A Short Efficient Synthesis of N,N-Didesmethyldiltiazem - An Important Product of N-Demethylation." Synthesis, 535-554 (2011).
Medina EM, Andrews BT, Nakatani E, and Catalano CE. "The Bacteriophage Lambda gpNu3 Scaffolding Protein is an Intrinsically Disordered and Biologically Functional Procapsid Assembly Catalyst." Journal of Molecular Biology, 412:723-736 (2011).
Atkins WM, Qian H. "Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification." Biochemistry., 50(19):3866-72 (2011).
Ritchie TK, Kwon H, Atkins WM. "Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2." J Biol Chem., 286(45):39489-96 (2011).
Honaker MT, Acchione M, Sumida JP, Atkins WM. "Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme." J Biol Chem., 286(49):42770-6 (2011).
Woods CM, Fernandez C, Kunze KL, Atkins WM. "Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysis." Biochemistry, 50(46):10041-51 (2011).
Yang J, Atkins WM, Isoherranen N, Paine MF, Thummel KE. "Evidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam." Clin Pharmacol Ther., 91(3):442-9 (2011).
Naraharisetti SB, Lin YS, Rieder M, Marciante K, Psaty BM, Thummel KE, Totah RA. "Human Liver Expression of CYP2C8: gender, age and genotype effects." Drug Metab Dispos., 2010 Feb 26 [Epub ahead of print].
Morris RM, Nunn BL, Frazar C, Goodlett DR, Ting YS, Rocap G. "Comparative metaproteomics reveals ocean-scale shifts in microbial nutrient utilization and energy transduction." ISME J., 2010 Feb 18 [Epub ahead of print].
Lee KK. "Architecture of a nascent viral fusion pore." EMBO J., 2010 Feb 18 [Epub ahead of print].
Morrissey C, Gallis B, Solazzi JW, Kim BJ, Gulati R, Vakar-Lopez F, Goodlett DR, Vessella RL, Sasaki T. "Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells." Anticancer Drugs, 2010 Feb 2 [Epub ahead of print].
Balogh LM, Le Trong I, Kripps KA, Shireman LM, Stenkamp RE, Zhang W, Mannervik B, Atkins WM. "Substrate Specificity Combined with Stereopromiscuity in Glutathione Transferase A4-4-Dependent Metabolism of 4-Hydroxynonenal." Biochemistry (2010).
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