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What Research Opportunities Exist?

student in labThe faculty in Medicinal Chemistry offer diverse opportunities for study and research at the interface between chemistry and biology with emphasis on issues of biomedical importance. These include the role of phase I and II biotransformation processes in toxification and detoxification reactions, the metabolic consequences of phenotypic and genotypic diversity in the population, drug metabolism and enzyme kinetics, drug/drug and drug/herbal interactions, protein engineering, mechanisms of pathogen resistance, molecular modeling of peptides and proteins and vaccine development - to name but a few. In addition to specialized training acquired during their medicinal chemistry thesis work, graduates acquire a broad foundation in biochemistry, pharmacology and molecular biology which is important in the rapidly evolving, multidisciplinary biomedical arena. This is aided by the Department’s commitment to interdisciplinary efforts in the study of metabolism-based mechanisms of drug interactions with faculty in Pharmaceutics, a pre-doctoral training grant in the pharmacological sciences with Pharmaceutics and Pharmacology, as well as faculty involvement in the School of Public Health’s Center for Ecogenetics and Environmental Health and in the Biomedical Structure and Design Program.

In addition, the Department houses the Analytical Biopharmacy Core which aims to serve the University and the local biotechnology communities in their efforts to perform biophysical characterization of macromolecular drugs and delivery platforms including proteins, polymers, nucleic acids, or other nanodevices. This Core facility, established through the Center for Intracellular Delivery of Biologics, provides a further collaborative link between the Departments of Bioengineering, Chemical Engineering, and the Fred Hutchinson Cancer Research Center.
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What Research Opportunities Exist? The faculty in Medicinal Chemistry offer diverse opportunities for study and research at the interface between chemistry and biology with emphasis on issues of biomedical importance. These include the role of phase I and II biotransformation processes in toxification and detoxification reactions, the metabolic consequences of phenotypic and genotypic diversity in the population, drug metabolism and enzyme kinetics, drug/drug and drug/herbal interactions, protein engineering, mechanisms of pathogen resistance, molecular modeling of peptides and proteins and vaccine development - to name but a few. In addition to specialized training acquired during their medicinal chemistry thesis work, graduates acquire a broad foundation in biochemistry, pharmacology and molecular biology which is important in the rapidly evolving, multidisciplinary biomedical arena.
Our Mission The goal of graduate program training in Medicinal Chemistry is to prepare highly trained, versatile individuals for a career in the pharmaceutical sciences; we are proud of our record of outstanding graduate students who now enjoy fruitful careers in academia, the pharmaceutical and biotechnology industries as well as with government and other regulatory agencies. If you are interested further in our Doctoral Program, please surf around our newly-designed web site and feel free to contact us directly if you require any additional information.
What is Medicinal Chemistry? Medicinal Chemistry is a discipline with a traditional focus on organic synthetic chemistry with the broad goals of drug discovery and optimization. The Department of Medicinal Chemistry at the University of Washington, since its inception in 1980, has always departed somewhat from this tradition given the focus of many of its faculty on the research areas of mechanistic drug metabolism, toxicology and bioanalytical chemistry. In recent years research activities in the Department have been broadened further by the addition of several faculty members with expertise in the areas of biological mass spectrometry and biophysical virology.