Course Listings

Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.

Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: AWSp jointly with PCEUT 520.

Covers the fundamental aspects of contemporary medicinal chemistry. Discusses the chemical characteristics of drugs and drug targets, pharmaceutical properties of drugs, drug metabolism, toxicology, and pharmacogenetics. Focuses on various drug classes; their biochemistry, pharmacology, mechanism of action, and toxicology. Offered: A.

Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Not currently offered.

Discussion of computational and experimental strategies for the de novo design of peptide-based diagnostics and therapeutics. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor.  Credit/no-credit only. Offered: AWSpS.

Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Characterization of antibody-antigen interactions with new methods, emphasis on mass spectrometry-based techniques for glycoproteins. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: A.

Link to course website

Discussion of pertinent articles from current literature. Credit/no-credit only. Offered: AWSp.

Quarterly cumulative examinations for graduate students. Credit/no-credit only. Offered: AWSp.

Credit/no-credit only. Offered: AWSpS.

Credit/no-credit only. Offered: AWSpS.

Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.

Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with PCEUT 520.

Considerations of the biochemical mechanisms for the biotransformation of drugs and foreign compounds. Includes reaction mechanisms, ultrastructural considerations,induction mechanisms, methodology, kinetics of inhibition and activation, steroid and amine metabolism. Offered: jointly with PHCOL 527; W, odd years.

Link to course website

The first part of the course includes in-depth treatment of thermodynamics and kinetics of protein-ligand interactions and protein-protein interactions. This section also includes an introduction to the structure and function of therapeutic antibodies.  The second part of the course includes theoretical and practical aspects of biophysical methods not covered in most other courses, including surface plasmon resonance, scanning and titrating calorimetry, cryoEM, H/D exchange mass spectrometry and other specialized methods with particular utility in modern drug discovery. The third part of this course provides examples of theory and methods from the first two parts, with particular emphasis on therapeutic proteins discussed, including viruses, therapeutic antibodies, bispecific antibodies, Fc-fusion proteins, and drug targets. Students are responsible for all of the material presented in the lecture notes, the classroom lectures and, in addition, any reading material assigned by the instructors. Students will directly interact with industry scientists with expertise in biophysical analysis. Offered: W, even years.

Link to course website

Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor.  Credit/no-credit only. Offered: AWSpS.

Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Characterization of antibody-antigen interactions with new methods, emphasis on mass spectrometry-based techniques for glycoproteins. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: W.

Covers advanced topics in medical biochemistry directly related to understanding disease and drug therapy in pharmacy practice. Areas of study include enzymes of drug metabolism, metabolic control of disease states, signal transduction, virology, coagulation and complement cascades, cellular transport, and DNA replication/transcription. Offered: W.

Link to course website

Discussion of pertinent articles from current literature. Credit/no-credit only. Offered: AWSp.

Quarterly cumulative examinations for graduate students. Credit/no-credit only. Offered: AWSp.

Credit/no-credit only. Offered: AWSpS.

Introductory course for undergraduate students covering aspects of medicinal chemistry and pharmaceutical science, ranging from history of drug discovery and development and current practices in the pharmaceutical industry, to principles of drug metabolism, transport processes and mechanisms of inter-individual variability in drug response as they relate to genetic and environmental factors. Prerequisite: CHEM 223, CHEM 227, or permission of instructor.  Offered: Sp.

Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.

Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with PCEUT 520.

Application of integrated data from the physical and biological sciences to problems of chemotherapy, including transport of drugs to site of action, biotransformation of drugs, interaction of drugs with enzyme systems, and recent advances in drug design. Prerequisite: CHEM 457, CHEM 531, and BIOC 442, or permission of instructor. Offered: Sp.

Students present and discuss primary literature that integrates aspects of medicinal chemistry and pharmacokinetics with the physiology, pharmacology, and genetics of therapeutic drug targets. Examples of targets discussed include ion channels and enzymes relevant to cardiovascular disease, and neurodegenerative disease. Credit/no-credit only. Offered: Sp.

Covers the basics of modern ionization methods and mass analyzers; small molecule structure assignment, quantitative assay development by LC-MS and metabolomics; quantitative discovery-based proteomics and validation methods; and peptide sequence determination, post-translational modification mapping, and protein structure determination methods. Prerequisite: permission of instructor. Offered: Sp.

Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Characterization of antibody-antigen interactions with new methods, emphasis on mass spectrometry-based techniques for glycoproteins. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Mechanisms of action, spectrum of coverage, resistance patterns, toxicity, and therapeutic applications of antibiotics, antifungals, and antivirals. Also covering chemical and biologic properties of agents used to prevent or treat infectious diseases, including diagnostic, prophylactic, and therapeutic uses of immunizing agents. Prerequisite: MICROM 301, MICROM 302, MEDCH 570, or equivalent, PharmD major, or permission of instructor. Offered: Sp.

Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: Sp.

Discussion of pertinent articles from current literature. Credit/no-credit only. Offered: AWSp.

Quarterly cumulative examinations for graduate students. Credit/no-credit only. Offered: AWSp.

Credit/no-credit only. Offered: AWSpS.

Credit/no-credit only. Offered: AWSpS.

Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.

Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Characterization of antibody-antigen interactions with new methods, emphasis on mass spectrometry-based techniques for glycoproteins. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Covers recent advances in oxidative metabolism of lipids, lipid biosynthesis, and application of advanced mass spectrometry to the analysis of lipids and oxidized lipids. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.

Credit/no-credit only. Offered: AWSpS.

Credit/no-credit only. Offered: AWSpS.