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Maria Agapova Graduate Student
Admission: Fall 2010
- BS, Randolph College, Virginia
- MSc, Bocconi University, Italy
Disease progression modeling, cost-effectiveness analysis and economic evaluation of health interventions in transitioning countries.
Rachel Allen Clinical Assistant Professor
Clinical Assistant Professor, Department of Pharmacy,
Office of Professional Pharmacy Education, BPLC Director
- PharmD, University of Washington
- Community practice
- Clinical community pharmacy services
Gail Anderson Professor
Professor, Department of Pharmacy; Adjunct Professor, Department of Pharmaceutics, Department of Neurological Surgery, UW Medicine
- PhD in Pharmaceutics, University of Washington
- Master of Science in Pharmacy Practice, University of Washington
- Bachelor of Science in Pharmacy, University of Washington
- Clinical pharmacokinetics
- Epilepsy and neurotrauma
- Pharm 561 and 562: Pharmacotherapeutics
- Pharm 549: Drug therapy for the elderly
- Pharm 533: Pharmacokinetics
- Pceut 532: Clinical Pharmacokinetics
- Pceut 533: Biopharmaceutics and drug delivery
- Med Chem 525: Alternative and Complementary Medicine (online)
Gail D. Anderson, PhD, obtained her academic education from the University of Washington where she obtained a Bachelor of Science in Pharmacy, Master of Science in Pharmacy Practice and PhD in Pharmaceutics. She completed a fellowship in Clinical Pharmacokinetics at the State University of New York at Buffalo and an NIH training fellowship at the Regional Epilepsy center at UW Medical Center. Her research interests include treatment issues in traumatic brain injury and epilepsy, pharmacokinetics and drug interactions.
Dr. Anderson has been an investigator on numerous federal and industry funded research grants and is author of over 100 peer-reviewed publications and chapters. She teaches clinical pharmacokinetics and antiepileptic drugs to students in a variety of health professional programs, including pharmacy, nursing and physician assistants. Dr. Anderson also offers a self-paced online course on natural products. In 2005, she won the UW Gibaldi Excellence in Teaching Award and in 2011 the Distinguished Alumna for Excellence in Pharmaceutical Science and Research Award from the UW School of Pharmacy. Dr. Anderson is active in various pharmacy and epilepsy professional organizations and has been on the professional advisory board of the Epilepsy Foundation Northwest since 1993. She serves on the editorial board of the journal Clinical Pharmacokinetics and as a grant reviewer for several National Institutes of Health review committees including, NCCAM, NINDS and NICHD.
Peer Reviewed Publications
- Anderson GD, Hakimian S. Pharmacokinetics of antiepilectic drugs in patients with hepatic and renal impairment. Clin Pharmacokinet 2014; 53:29-39.
- Vonder Haar C, Anderson GD, Elmore BE, Moore LH, Bunton AM, Kantor ED, Farin FM, Bammler TK, Macdonald JW, Hoane MR. Comparison of the Effect of Minocycline and Simvastatin on Functional Recovery and Gene Expression in a Rat Traumatic Brain Injury Model. J Neurotrauma. 2013 Dec 5; ePUB ahead of print.
- Anderson GD, Peterson TC, Vonder Haar C, Farin FM, Bammler TK, Kantor ED, MacDonald JW, Hoane MR. Comparison of the effects of erythropoietin and anakinra on functional recovery and gene expression in a traumatic brain injury model. Front Neurosci. 2013 Oct 17; 4:129. doi: 10.3389/fphar.2013.00129.
- Ruddy J, Emerson J, Moss R, Genatossio A, McNamara S, Burns JL, Anderson GD, Rosenfeld M. Sputum tobramycin concentrations in cystic fibrosis patients with repeated administration of inhaled tobramycin. J Aerosol Med Pulm Drug Deliv. 2013 Apr; 26(2):69-75.
- Anderson GD, Peterson TC, Farin FM, Bammler TK, Beyer RP, Kantor ED, Hoane MR. The effect of nicotinamide on gene expression in a traumatic brain injury model. Front Neurosci. 2013 Feb 26; 7:21.
- Peterson TC, Anderson GD, Kantor ED, Hoane MR. A comparison of the effects of nicotinamide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat. J Neurotrauma. 2012 Dec 10; 29(18):2823-30.
- Jimenez N, Anderson GD, Shen DD, Nielsen SS, Farin FM, Seidel K, Lynn AM. Is ethnicity associated with morphine’s side effects in children? Morphine pharmacokinetics, analgesic response, and side effects in children having tonsillectomy. Paediatr Anaesth. 2012 Jul; 22(7):669-75.
- Anderson GD, Saneto RP. Current Oral and Non-oral Routes and Antiepileptic Drug Delivery. Adv Drug Deliv Rev. 2012 Jul; 64(10):911-8.
- Vonder Haar C, Anderson GD, Hoane MR. Continuous nicotinamide administration improves behavioral recovery and reduces lesion size following bilateral frontal controlled cortical impact injury. Behav Brain Res. 2011 Oct 31; 224(2):311-7.
- Anderson GD, Farin FM, Bammler TK, Beyer RP Swan A, Wilkerson HW, Kantor ED, Hoane MR. The effect of progesterone dosing on gene expression following traumatic brain injury. J Neurotrauma. 2011 Sep; 28(9):1827-43.
- Lynn AM, Bradford H, Kantor ED, Andrew M, Vicini P, Anderson GD. Ketorolac tromethamine: stereo-specific pharmacokinetics and single-dose use in postoperative infants aged 2-6 months. Paediatr Anaesth. 2011 Mar; 21(3):325-34.
William Atkins Professor
Sid Nelson Endowed Professor of Medicinal Chemistry
BS in Chemistry, The College of William and Mary
MA in Pharmacology, Harvard University
PhD in Biochemistry, The University of Illinois
Postdoctoral Studies in Protein Dynamics, Penn State University
- Structure-function mechanism of glutathione S-transferases and cytochrome P450
- Protein engineering of supramolecular aggregates
Dr. Atkins is a biophysical enzymologist with two primary areas of interest. One area of research focus includes mechanisms of detoxication enzymes and transporters, which play critical roles in drug metabolism, drug-drug interactions, and interindividual responses to drugs. These enzymes are a fascinating variation on “traditional” enzymes because they have no defined substrates but instead have evolved to recognize a broad range of structurally diverse substrates. Atkins utilizes a combination of spectroscopic methods, mass spectrometry, chemical synthesis, computational methods, and molecular biology techniques to study the structure-function relationships of these enzymes, including Cytochrome P450s (CYPs), glutathione s-transferases (GSTs), and P-glycoprotein (P-gp).
The second area of interest includes therapeutic proteins, such as those used to treat various cancers and autoimmune diseases. The Atkins lab has recently moved into this research field and studies biophysical properties of antibody-drug conjugates and fusion proteins to understand the factors that determine their stability in serum and their interactions with their targets. Taken together, the research projects in the Atkins lab aim to improve the utility of small molecule drugs or biologics.
This research prepares students and postdoctoral scientists for careers in the pharmaceutical industry, the biotechnology sector and academia.
- Conner KP, Cruce AA, Krzyaniak MD, Schimpf AM, Frank DJ, Ortiz de Montellano P, Atkins WM, Bowman MK. “Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1.” Biochemistry 2015 Feb 10; 54(5):1198-207. PubMed link.
- Atkins WM. “Biological messiness vs. biological genius: Mechanistic asepcts and roles of protein promiscuity.” J Steroid Biochem Mol Biol. 2014 Sep 12 [Epub ahead of print]. PubMed link.
- Conner KP, Schimpf AM, Cruce AA, McLean KJ, Munro AW, Frank DJ, Krzyaniak MD, Ortiz de Montellano P, Bowman MK, Atkins WM. “Strength of axial water ligation in substrate-free cytochrome P450s is isoform dependent.” Biochemistry 2014 Mar 11; 53(9):1428-34. PubMed link.
- Scian M, Acchione M, Li M, Atkins WM. “Reaction dynamics of ATP hydrolysis catalyzed by P-glycoprotien.” Biochemistry 2014 Feb 18; 53(6):991-1000. PubMed link.
- Zhao C, Gao Q, Roberts AG, Shaffer SA, Doneanu CE, Xue S, Goodlett DR, Nelson SD, Atkins WM. “Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5).” Biochemistry 2012 Nov 27; 51(47):9488-500. ACS link.
- Conner KP, Vennam P, Woods CM, Krzyaniak MD, Bowman MK, Atkins WM. “1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes.” Biochemistry 2012 Aug 14;51(32):6441-57. ACS link.
- Acchione M, Kwon H, Jochheim CM, Atkins WM. “Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates.” MAbs 2012 May-Jun;4(3):362-72. PubMed link.
- Ritchie TK, Kwon HW, Atkins WM. “Conformational Analysis of Human ATP-Binding Cassette Transporter ABCB1 in Lipid Nanodiscs and Inhibition by the Antibodies MRK16 and UIC2.” J Biol Chem, 286(45):39489-96 (2011). PubMed link.
- Balogh LM, Atkins WM. “Interactions of glutathione transferases with 4-hydroxynonenal.” Drug Metab Rev. 43(2):165-78 (2011).
- Honaker MT, Acchione M, Sumida JP, Atkins WM. “Ensemble Perspective for Catalytic Promiscuity: Calorimetric Analysis of the Active Site Conformational Landscape of a Detoxification Enzyme.” J Biol Chem. 286(49):42770-6 (Dec 9, 2011). PubMed link.
Thomas Baillie Professor, Dean Emeritus
PhD in organic chemistry, DSc in chemistry, University of Glasgow;
MSc in biochemistry, University of London;
BSc in chemistry, University of Glasgow
- Application of mass spectrometry and associated techniques to problems in pharmacology, toxicology and clinical research
- Mechanistic aspects of drug metabolism and toxicology
Dr. Baillie’s academic career began at the University of London, in 1975, where he was a lecturer in the Department of Clinical Pharmacology. In 1978, he joined the University of California – San Francisco and, in 1981, he became a member of the UW Department of Medicinal Chemistry faculty, where he stayed until joining Merck & Co. in 1994. At Merck, he served as executive director of preclinical drug metabolism, and subsequently as vice president and global head of drug metabolism and pharmacokinetics. He returned to the UW School of Pharmacy as dean in 2008.
Baillie’s research has focused on how the body forms and processes chemically reactive, potentially harmful products during the process of drug metabolism. These findings are important in guiding the design of safer medicines. Baillie was awarded a Senior International Fogarty Fellowship (1988-89) for research conducted at the Karolinska Institute in Stockholm, Sweden. He is author of more than 250 publications, serves on the advisory boards of several scientific journals and professional organizations and, in 2002, he was a co-recipient of the James R. Gillette Award from the American Society of Pharmacology & Experimental Therapeutics. In 2009, he received a Lifetime Achievement Award from the International Isotope Society for distinguished service to the society. In 2012, he received the Founders Award from the American Chemical Society Division of Chemical Toxicology. He has been elected as a Fellow of the Royal Society of Chemistry, the Japanese Society for the Study of Xenobiotics, and the American Chemical Society.
Preeti Bajaj Graduate Student
Admission: Fall 2009
BS, Biomedical Engineering, Johns Hopkins University
Research Interests: Pharmacoeconomics and outcomes research locally and in resource poor countries, informed decision-making and efficiency in drug and medical device development
Souvik Banerjee Post-Doctoral Pfizer Fellow
Pfizer Fellow 2014-2016
Souvik joined the Pfizer postdoctoral fellowship after completing his PhD in Economics from University at Albany, SUNY in August 2014. In his dissertation he examined the impact of mental illness on labor market outcomes like employment and labor supply, using a latent continuous measure for mental illness. Souvik has presented his work at the Ifo/CESifo Conference on Empirical Health Economics, Munich, Germany and also at the Annual Health Econometrics Workshop, Chapel Hill, NC in 2013.
In the position as a postdoctoral fellow he will be working under the primary supervision of Lou Garrison and will also be mentored by Sean D. Sullivan and Anirban Basu. In the summer of 2015 Souvik is expected to work with Dick Willke at Pfizer, New York, NY.
Aasthaa Bansal Research Assistant Professor
Research Assistant Professor, Department of Pharmacy
PhD in Biostatistics, University of Washington
BMath in Computer Science, University of Waterloo, Canada
Aasthaa Bansal received her PhD in biostatistics from the UW and completed her postdoctoral fellowship at the UW. Prior to arriving in Seattle, she received a BMath in Computer Science from the University of Waterloo, Canada.
Her research interests include the statistical evaluation of biomarkers and medical tests for disease prognosis and treatment selection. In addition to her background developing statistical methodology, she was involved in collaborative research at the Center for Biomedical Statistics from 2009 to 2013. While there, she worked with academic investigators on the statistical analysis of studies in colon cancer screening, esophageal cancer treatment, institutional profiling, chronic illness management and juvenile arthritis.
Bansal A, Pepe MS. When Does Combining Markers Improve Classification Performance and What Are Implications for Practice?Stat Med.2013 May 20;32(11):1877-92.
Bansal A, Pepe MS. Estimating Improvement in Prediction with Matched Case-Control Designs.Lifetime Data Anal.2013 Apr;19(2):170-201.
Kerr KF,Bansal A, Pepe MS.Further insight into the incremental value of new markers: the interpretation of performance measures and the importance of clinical context.Am J Epidemiol.2012 Sep 15;176(6):482-7. Epub 2012 Aug 8.
Larson-Meyer DE, Palm S,Bansal A, Austin KJ, Hart AM, Alexander BM. Influence of Running and Walking on Hormonal Regulators of Appetite in Women.J Obes.2012;2012:730409.
Weinert C, Cudney S, Comstock B,Bansal A. Computer Intervention Impact on Psychosocial Adaptation of Rural Women with Chronic Conditions.Nurs Res.2011 Mar-Apr;60(2):82-91.
Adams Waldorf KM, Gravett MG, McAdams RM, Paolella LJ, Gough GM, Carl DJ,Bansal A, Liggitt HD, Kapur RP, Reitz FB, Rubens CE. Choriodecidual Group B Streptococcal Inoculation Induces Fetal Lung Injury without Intra-Amniotic Infection and Preterm Labor inMacaca Nemestrina.PLoS One.2011;6(12):e28972.
Anirban Basu Professor, Director of PORPP
Professor, Department of Pharmacy
Director, Pharmaceutical Outcomes Research & Policy Program
PhD in Health Economics, Public Policy, University of Chicago
MS in Biostatistics, University of North Carolina – Chapel Hill
MS in Pharmaceutical Sciences, University of Toledo
BS in Pharmaceutical Sciences, Jadavpur University
Dr. Basu is a professor in the Departments of Health Services and Pharmacy at the University of Washington, Seattle. He is also a faculty research fellow at the National Bureau of Economic Research. Dr. Basu’s research interests lie in revealing heterogeneity in clinical and economic outcomes in order to establish the value of individualized care. His work has focused on translating such information for public policy using innovative methods in comparative effectiveness and cost-effectiveness research. Dr. Basu has developed methods dealing with issues related to modeling health expenditure data, which is renowned for its idiosyncrasies and the difficulties it poses for applied health services researchers. He has also worked on methods used for making causal inferences using observational data. His applied work spans many dimensions that include analyzing the cost-effectiveness of prostate cancer treatments, establishing the value of individualized care based on patient preferences, developing models to predict quality of life of patients with multiple comorbidities, measuring the effect of patients’ health on the quality of life of their partners, developing novel methods to estimate long-term costs of prostate cancer therapies, estimating the future value of research in diagnosing and finding a cure for Duchenne muscular dystrophy, developing simulation models for evaluating the cost-effectiveness of pharmacological treatment algorithms in schizophrenia, and comparative effectiveness research on the dynamic intensification of glucose lowering therapies in diabetes.
Dr. Basu is an Associate Editor for both Health Economics and the Journal of Health Economics and has taught courses on decision analysis, cost-effectiveness analysis and health services research methods. He has received numerous recognitions for his work throughout his career and for which he remains grateful to his mentors and peers: the NARSAD Wodecroft Young Investigator Award (2005), the Research Excellence Award for Methodological Excellence (2007) and the Bernie O’Brien New Investigator Award (2009) from the International Society for Pharmacoeconomics and Outcomes Research, the Alan Williams Health Economics Fellowship (2008) from the University of York, UK and the Labelle Lectureship in Health Economics (2009) from McMaster University, Canada.
Larry Bauer Professor
Professor, Department of Pharmacy; Adjunct Professor, Department of Laboratory Medicine, UW Medicine
PharmD, University of Kentucky; Bachelor of Science in Pharmacy, University of Washington
- Drug interactions
- Individualization of drug therapy
- Pharmacy 560: Therapeutics II
- Pharmacy 566: Applied Kinetics
- Pharmacy 559: Therapeutics I
- Pharmacy 301: Medications & Health
Dr. Bauer is a member of several clinical pharmacology and clinical pharmacy professional organizations. He is a reviewer for several scientific publications, was Consulting Editor of Clinical Pharmacy (1981 – 1990), Field Editor of ASHP Signal (1981 – 1983), and on the Editorial Board of Clinical Pharmacology and Therapeutics (1998-2007).
Currently, he is on the Editorial Board of Antimicrobial Agents and Chemotherapy. He is a Fellow in the American College of Clinical Pharmacology and in the American College of Clinical Pharmacy. Dr. Bauer has precepted post-doctoral fellows in clinical pharmacokinetics and pharmacodynamics who currently have faculty appointments in schools of pharmacy or are employed in pharmaceutical industry. He is the author of Applied Clinical Pharmacokinetics and Clinical Pharmacokinetics Handbook.